{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:28:02Z","timestamp":1773084482006,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The carotenoid-binding protein (CBP) of the domesticated silkworm, Bombyx mori, a major determinant of cocoon color, is likely to have been substantially influenced by domestication of this species. We analyzed the structure of the CBP gene in multiple strains of B. mori, in multiple individuals of the wild silkworm, B. mandarina (the putative wild ancestor of B. mori), and in a number of other lepidopterans. We found the CBP gene copy number in genomic DNA to vary widely among B. mori strains, ranging from 1 to 20. The copies of CBP are of several types, based on the presence of a retrotransposon or partial deletion of the coding sequence. In contrast to B. mori, B. mandarina was found to possess a single copy of CBP without the retrotransposon insertion, regardless of habitat. Several other lepidopterans were found to contain sequences homologous to CBP, revealing that this gene is evolutionarily conserved in the lepidopteran lineage. Thus, domestication can generate significant diversity of gene copy number and structure over a relatively short evolutionary time.<\/jats:p>","DOI":"10.1534\/genetics.110.124982","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T04:45:23Z","timestamp":1295325923000},"page":"965-976","source":"Crossref","is-referenced-by-count":23,"title":["Diversity in Copy Number and Structure of a Silkworm Morphogenetic Gene as a Result of Domestication"],"prefix":"10.1093","volume":"187","author":[{"given":"Takashi","family":"Sakudoh","sequence":"first","affiliation":[{"name":"Division of Radiological Protection and Biology , National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Division of Radiological Protection and Biology , National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kuroki","sequence":"additional","affiliation":[{"name":"MetaSystems Research Team, Computational Systems Biology Research Group, Advanced Computational Sciences Department, RIKEN Advanced Science Institute, Yokohama, Kanagawa 230-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asao","family":"Fujiyama","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Genomics, National Institute of Genetics and Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan"},{"name":"Principles of Informatics Research Division, National Institute of Informatics, Chiyoda, Tokyo 101-8430, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kohara","sequence":"additional","affiliation":[{"name":"Genome Biology Lab Center for Genetic Resource Information, National Institute of Genetics, Mishima 411-8540, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Radiological Protection and Biology , National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Division of Radiological Protection and Biology , National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo, Tokyo 113-8657, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Nakagaki","sequence":"additional","affiliation":[{"name":"Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano 386-8567, Japan and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Banno","sequence":"additional","affiliation":[{"name":"Genetic Resources Technology, Kyushu University, Fukuoka, Fukuoka 812-0053, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Tsuchida","sequence":"additional","affiliation":[{"name":"Division of Radiological Protection and Biology , National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,3,1]]},"reference":[{"key":"2022110713290741800_BIB1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/BST0340343","volume":"34","year":"2006","journal-title":"Biochem. 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