{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:20:20Z","timestamp":1785565220968,"version":"3.56.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The LIN-1 ETS transcription factor plays a pivotal role in controlling cell fate decisions during development of the Caenorhabditis elegans vulva. Prior to activation of the RTK\/Ras\/ERK-signaling pathway, LIN-1 functions as a SUMOylated transcriptional repressor that inhibits vulval cell fate. Here we demonstrate using the yeast two-hybrid system that SUMOylation of LIN-1 mediates interactions with a protein predicted to be involved in transcriptional repression: the RAD-26 Mi-2\u03b2\/CHD4 component of the nucleosome remodeling and histone deacetylation (NuRD) transcriptional repression complex. Genetic studies indicated that rad-26 functions to inhibit vulval cell fates in worms. Using the yeast two-hybrid system, we showed that the EGL-27\/MTA1 component of the NuRD complex binds the carboxy-terminus of LIN-1 independently of LIN-1 SUMOylation. EGL-27 also binds UBC-9, an enzyme involved in SUMOylation, and MEP-1, a zinc-finger protein previously shown to bind LIN-1. Genetic studies indicate that egl-27 inhibits vulval cell fates in worms. These results suggest that LIN-1 recruits multiple proteins that repress transcription via both the SUMOylated amino-terminus and the unSUMOylated carboxy-terminus. Assays in cultured cells showed that the carboxy-terminus of LIN-1 was converted to a potent transcriptional activator in response to active ERK. We propose a model in which LIN-1 recruits multiple transcriptional repressors to inhibit the 1\u00b0 vulval cell fate, and phosphorylation by ERK converts LIN-1 to a transcriptional activator that promotes the 1\u00b0 vulval cell fate.<\/jats:p>","DOI":"10.1534\/genetics.114.172668","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T09:44:07Z","timestamp":1420710247000},"page":"761-775","source":"Crossref","is-referenced-by-count":18,"title":["Conversion of the LIN-1 ETS Protein of<i>Caenorhabditis elegans<\/i>from a SUMOylated Transcriptional Repressor to a Phosphorylated Transcriptional Activator"],"prefix":"10.1093","volume":"199","author":[{"given":"Elizabeth R","family":"Leight","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Fantz","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110"},{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Pepin","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Ratliff","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, Manhattan, Kansas 66506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaa H","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, Manhattan, Kansas 66506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Herman","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, Manhattan, Kansas 66506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 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