{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:16:16Z","timestamp":1790421376681,"version":"4.1.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long interspersed elements 1 (L1) are active mobile elements that constitute almost 17% of the human genome. They amplify through a \u201ccopy-and-paste\u201d mechanism termed retrotransposition, and de novo insertions related to these elements have been reported to cause 0.2% of genetic diseases. Our previous data demonstrated that the endonuclease complex ERCC1-XPF, which cleaves a 3\u2032 DNA flap structure, limits L1 retrotransposition. Although the ERCC1-XPF endonuclease participates in several different DNA repair pathways, such as single-strand annealing, or in telomere maintenance, its recruitment to DNA lesions is best characterized in the nucleotide excision repair (NER) pathway. To determine if the NER pathway prevents the insertion of retroelements in the genome, we monitored the retrotransposition efficiencies of engineered L1 elements in NER-deficient cells and in their complemented versions. Core proteins of the NER pathway, XPD and XPA, and the lesion binding protein, XPC, are involved in limiting L1 retrotransposition. In addition, sequence analysis of recovered de novo L1 inserts and their genomic locations in NER-deficient cells demonstrated the presence of abnormally large duplications at the site of insertion, suggesting that NER proteins may also play a role in the normal L1 insertion process. Here, we propose new functions for the NER pathway in the maintenance of genome integrity: limitation of insertional mutations caused by retrotransposons and the prevention of potentially mutagenic large genomic duplications at the site of retrotransposon insertion events.<\/jats:p>","DOI":"10.1534\/genetics.116.188680","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T03:30:33Z","timestamp":1479180633000},"page":"139-153","source":"Crossref","is-referenced-by-count":39,"title":["The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition"],"prefix":"10.1093","volume":"205","author":[{"given":"Geraldine","family":"Servant","sequence":"first","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A","family":"Streva","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S","family":"Derbes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madushani I","family":"Wijetunge","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Neeland","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis B","family":"White","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria P","family":"Belancio","sequence":"additional","affiliation":[{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Tulane Center for Aging , Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M","family":"Roy-Engel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prescott L","family":"Deininger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Structural and Cellular Biology , School of Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"},{"name":"Department of Epidemiology , School of Public Health and Tropical Medicine, Tulane Cancer Center, Tulane University, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2022110309072920600_bib1","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1128\/MCB.00293-08","article-title":"ERCC1-XPF endonuclease facilitates DNA double-strand break repair.","volume":"28","author":"Ahmad","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"2022110309072920600_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkm888","article-title":"The ERCC1\/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells.","volume":"36","author":"Al-Minawi","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2022110309072920600_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0378-1119(96)00205-3","article-title":"Differential methylation of human LINE-1 retrotransposons in malignant cells.","volume":"176","author":"Alves","year":"1996","journal-title":"Gene"},{"key":"2022110309072920600_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1101\/gr.5558208","article-title":"Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health.","volume":"18","author":"Belancio","year":"2008","journal-title":"Genome Res."},{"key":"2022110309072920600_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gene.2007.12.022","article-title":"The impact of multiple splice sites in human L1 elements.","volume":"411","author":"Belancio","year":"2008","journal-title":"Gene"},{"key":"2022110309072920600_bib6","first-page":"455","article-title":"The aging clock and circadian control of metabolism and genome stability.","volume":"5","author":"Belancio","year":"2014","journal-title":"Front. Genet."},{"key":"2022110309072920600_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2867-6-13","article-title":"Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells.","volume":"6","author":"Belgnaoui","year":"2006","journal-title":"Cancer Cell Int."},{"key":"2022110309072920600_bib8","doi-asserted-by":"crossref","first-page":"9437","DOI":"10.1128\/JVI.02216-06","article-title":"Rate of recombinational deletion among human endogenous retroviruses.","volume":"81","author":"Belshaw","year":"2007","journal-title":"J. Virol."},{"key":"2022110309072920600_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/ng0597-6","article-title":"LINEs and Alus\u2013the polyA connection.","volume":"16","author":"Boeke","year":"1997","journal-title":"Nat. Genet."},{"key":"2022110309072920600_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(85)90197-7","article-title":"Ty elements transpose through an RNA intermediate.","volume":"40","author":"Boeke","year":"1985","journal-title":"Cell"},{"key":"2022110309072920600_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/nar\/gkj416","article-title":"APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells.","volume":"34","author":"Bogerd","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2022110309072920600_bib12","doi-asserted-by":"crossref","first-page":"17602","DOI":"10.1073\/pnas.0605476103","article-title":"RNA from the 5\u2032 end of the R2 retrotransposon controls R2 protein binding to and cleavage of its DNA target site.","volume":"103","author":"Christensen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022110309072920600_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrg2663","article-title":"Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity.","volume":"10","author":"Cleaver","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"2022110309072920600_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrfmmm.2009.08.005","article-title":"Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigmentosum group C protein.","volume":"685","author":"Clement","year":"2010","journal-title":"Mutat. Res."},{"key":"2022110309072920600_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/2491","article-title":"Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.","volume":"20","author":"Coin","year":"1998","journal-title":"Nat. Genet."},{"key":"2022110309072920600_bib16","doi-asserted-by":"crossref","first-page":"e1002384","DOI":"10.1371\/journal.pgen.1002384","article-title":"Repetitive elements may comprise over two-thirds of the human genome.","volume":"7","author":"de Koning","year":"2011","journal-title":"PLoS Genet."},{"key":"2022110309072920600_bib17","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1074\/jbc.273.14.7835","article-title":"DNA structural elements required for ERCC1-XPF endonuclease activity.","volume":"273","author":"de Laat","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2022110309072920600_bib18","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1101\/gr.282402","article-title":"Mammalian retroelements.","volume":"12","author":"Deininger","year":"2002","journal-title":"Genome Res."},{"key":"2022110309072920600_bib19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0168-9525(01)02492-1","article-title":"Recent duplication, domain accretion and the dynamic mutation of the human genome.","volume":"17","author":"Eichler","year":"2001","journal-title":"Trends Genet."},{"key":"2022110309072920600_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jmb.2005.09.050","article-title":"Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism.","volume":"354","author":"El-Sawy","year":"2005","journal-title":"J. Mol. Biol."},{"key":"2022110309072920600_bib21","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1073\/pnas.040559697","article-title":"The xeroderma pigmentosum group C gene leads to selective repair of cyclobutane pyrimidine dimers rather than 6\u20134 photoproducts.","volume":"97","author":"Emmert","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022110309072920600_bib22","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0092-8674(00)81997-2","article-title":"Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition.","volume":"87","author":"Feng","year":"1996","journal-title":"Cell"},{"key":"2022110309072920600_bib23","doi-asserted-by":"crossref","first-page":"18790","DOI":"10.1073\/pnas.1115249108","article-title":"Control of skin cancer by the circadian rhythm.","volume":"108","author":"Gaddameedhi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022110309072920600_bib24","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jmb.2006.01.089","article-title":"The human LINE-1 retrotransposon creates DNA double-strand breaks.","volume":"357","author":"Gasior","year":"2006","journal-title":"J. Mol. Biol."},{"key":"2022110309072920600_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.gene.2006.08.024","article-title":"Characterization of pre-insertion loci of de novo L1 insertions.","volume":"390","author":"Gasior","year":"2007","journal-title":"Gene"},{"key":"2022110309072920600_bib26","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.dnarep.2008.02.006","article-title":"ERCC1\/XPF limits L1 retrotransposition.","volume":"7","author":"Gasior","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"2022110309072920600_bib85","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0092-8674(02)00828-0","article-title":"Genomic deletions created upon LINE-1 retrotransposition.","volume":"110","author":"Gilbert","year":"2002","journal-title":"Cell"},{"key":"2022110309072920600_bib27","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.1128\/MCB.25.17.7780-7795.2005","article-title":"Multiple fates of L1 retrotransposition intermediates in cultured human cells.","volume":"25","author":"Gilbert","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2022110309072920600_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cr040483f","article-title":"Molecular mechanisms of mammalian global genome nucleotide excision repair.","volume":"106","author":"Gillet","year":"2006","journal-title":"Chem. Rev."},{"key":"2022110309072920600_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(03)00316-7","article-title":"The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.","volume":"113","author":"Groisman","year":"2003","journal-title":"Cell"},{"key":"2022110309072920600_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.gde.2012.02.006","article-title":"Active human retrotransposons: variation and disease.","volume":"22","author":"Hancks","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2022110309072920600_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13100-016-0065-9","article-title":"Roles for retrotransposon insertions in human disease.","volume":"7","author":"Hancks","year":"2016","journal-title":"Mob. DNA"},{"key":"2022110309072920600_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(95)90028-4","article-title":"The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.","volume":"82","author":"Henning","year":"1995","journal-title":"Cell"},{"key":"2022110309072920600_bib33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer.","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"2022110309072920600_bib34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/carcin\/23.4.599","article-title":"The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk.","volume":"23","author":"Hou","year":"2002","journal-title":"Carcinogenesis"},{"key":"2022110309072920600_bib35","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1093\/nar\/gkm181","article-title":"All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition.","volume":"35","author":"Kinomoto","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2022110309072920600_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.gene.2006.07.040","article-title":"Identification and characterization of novel polymorphic LINE-1 insertions through comparison of two human genome sequence assemblies.","volume":"390","author":"Konkel","year":"2007","journal-title":"Gene"},{"key":"2022110309072920600_bib37","doi-asserted-by":"crossref","first-page":"8036","DOI":"10.1073\/pnas.0601954103","article-title":"L1 retrotransposition in nondividing and primary human somatic cells.","volume":"103","author":"Kubo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022110309072920600_bib38","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome.","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"2022110309072920600_bib39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.mad.2013.02.006","article-title":"Cockayne syndrome: the expanding clinical and mutational spectrum.","volume":"134","author":"Laugel","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"2022110309072920600_bib40","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/genetics\/148.4.1743","article-title":"Posttranslational inhibition of Ty1 retrotransposition by nucleotide excision repair\/transcription factor TFIIH subunits Ssl2p and Rad3p.","volume":"148","author":"Lee","year":"1998","journal-title":"Genetics"},{"key":"2022110309072920600_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1750-1172-6-70","article-title":"Xeroderma pigmentosum.","volume":"6","author":"Lehmann","year":"2011","journal-title":"Orphanet J. Rare Dis."},{"key":"2022110309072920600_bib42","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/carcin\/16.7.1557","article-title":"Expression of a transfected DNA repair gene (XPA) in xeroderma pigmentosum group A cells restores normal DNA repair and mutagenesis of UV-treated plasmids.","volume":"16","author":"Levy","year":"1995","journal-title":"Carcinogenesis"},{"key":"2022110309072920600_bib43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/ng1293-413","article-title":"Characterization of molecular defects in xeroderma pigmentosum group C.","volume":"5","author":"Li","year":"1993","journal-title":"Nat. Genet."},{"key":"2022110309072920600_bib44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1749-6632.2009.05006.x","article-title":"APOBEC3 proteins inhibit LINE-1 retrotransposition in the absence of ORF1p binding.","volume":"1178","author":"Lovsin","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2022110309072920600_bib45","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1128\/MCB.16.9.4726","article-title":"Downstream 28S gene sequences on the RNA template affect the choice of primer and the accuracy of initiation by the R2 reverse transcriptase.","volume":"16","author":"Luan","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"2022110309072920600_bib46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0092-8674(93)90078-5","article-title":"Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition.","volume":"72","author":"Luan","year":"1993","journal-title":"Cell"},{"key":"2022110309072920600_bib47","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1722352","article-title":"Reverse transcriptase encoded by a human transposable element.","volume":"254","author":"Mathias","year":"1991","journal-title":"Science"},{"key":"2022110309072920600_bib48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(87)90151-6","article-title":"Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene.","volume":"51","author":"Mellon","year":"1987","journal-title":"Cell"},{"key":"2022110309072920600_bib49","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0092-8674(00)81998-4","article-title":"High frequency retrotransposition in cultured mammalian cells.","volume":"87","author":"Moran","year":"1996","journal-title":"Cell"},{"key":"2022110309072920600_bib50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ng898","article-title":"DNA repair mediated by endonuclease-independent LINE-1 retrotransposition.","volume":"31","author":"Morrish","year":"2002","journal-title":"Nat. Genet."},{"key":"2022110309072920600_bib51","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.dnarep.2011.04.019","article-title":"The xeroderma pigmentosum pathway: decision tree analysis of DNA quality.","volume":"10","author":"Naegeli","year":"2011","journal-title":"DNA Repair (Amst.)"},{"key":"2022110309072920600_bib52","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00018-009-8737-y","article-title":"DNA repair in mammalian cells: so DNA repair really is that important?","volume":"66","author":"Nouspikel","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"2022110309072920600_bib53","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/371432a0","article-title":"XPG endonuclease makes the 3\u2032 incision in human DNA nucleotide excision repair.","volume":"371","author":"O\u2019Donovan","year":"1994","journal-title":"Nature"},{"key":"2022110309072920600_bib54","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.genet.35.102401.091032","article-title":"Biology of mammalian L1 retrotransposons.","volume":"35","author":"Ostertag","year":"2001","journal-title":"Annu. Rev. Genet."},{"key":"2022110309072920600_bib55","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00018-015-2075-z","article-title":"Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation.","volume":"73","author":"Puumalainen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"2022110309072920600_bib56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0079-6603(04)79004-2","article-title":"Nucleotide excision repair.","volume":"79","author":"Reardon","year":"2005","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"2022110309072920600_bib57","doi-asserted-by":"crossref","first-page":"e02008","DOI":"10.7554\/eLife.02008","article-title":"APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition.","volume":"3","author":"Richardson","year":"2014","journal-title":"eLife"},{"key":"2022110309072920600_bib58","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1093\/emboj\/cdg489","article-title":"The comings and goings of nucleotide excision repair factors on damaged DNA.","volume":"22","author":"Riedl","year":"2003","journal-title":"EMBO J."},{"key":"2022110309072920600_bib59","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.bbrc.2004.07.030","article-title":"Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.","volume":"321","author":"Saijo","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2022110309072920600_bib60","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1093\/nar\/28.19.3771","article-title":"Role of the nucleotide excision repair gene ERCC1 in formation of recombination-dependent rearrangements in mammalian cells.","volume":"28","author":"Sargent","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2022110309072920600_bib61","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.dnarep.2011.04.017","article-title":"Multistep damage recognition, pathway coordination and connections to transcription, damage signaling, chromatin structure, cancer and aging: current perspectives on the nucleotide excision repair pathway.","volume":"10","author":"Sch\u00e4rer","year":"2011","journal-title":"DNA Repair (Amst.)"},{"key":"2022110309072920600_bib62","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1128\/MCB.01888-06","article-title":"Cell divisions are required for L1 retrotransposition.","volume":"27","author":"Shi","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2022110309072920600_bib63","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1093\/nar\/24.17.3370","article-title":"Mutational analysis of the human nucleotide excision repair gene ERCC1.","volume":"24","author":"Sijbers","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"2022110309072920600_bib64","first-page":"1354","article-title":"Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.","volume":"61","author":"Spitz","year":"2001","journal-title":"Cancer Res."},{"key":"2022110309072920600_bib65","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0168-9525(02)02592-1","article-title":"Genome architecture, rearrangements and genomic disorders.","volume":"18","author":"Stankiewicz","year":"2002","journal-title":"Trends Genet."},{"key":"2022110309072920600_bib66","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12864-015-1374-y","article-title":"Sequencing, identification and mapping of primed L1 elements (SIMPLE) reveals significant variation in full length L1 elements between individuals.","volume":"16","author":"Streva","year":"2015","journal-title":"BMC Genomics"},{"key":"2022110309072920600_bib67","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1097-2765(00)80132-X","article-title":"Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.","volume":"2","author":"Sugasawa","year":"1998","journal-title":"Mol. Cell"},{"key":"2022110309072920600_bib68","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1101\/gad.866301","article-title":"A multistep damage recognition mechanism for global genomic nucleotide excision repair.","volume":"15","author":"Sugasawa","year":"2001","journal-title":"Genes Dev."},{"key":"2022110309072920600_bib69","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1568-7864(01)00008-8","article-title":"A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.","volume":"1","author":"Sugasawa","year":"2002","journal-title":"DNA Repair (Amst.)"},{"key":"2022110309072920600_bib70","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.molcel.2009.09.035","article-title":"Two-step recognition of DNA damage for mammalian nucleotide excision repair: directional binding of the XPC complex and DNA strand scanning.","volume":"36","author":"Sugasawa","year":"2009","journal-title":"Mol. Cell"},{"key":"2022110309072920600_bib71","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0092-8674(02)00839-5","article-title":"Human l1 retrotransposition is associated with genetic instability in vivo.","volume":"110","author":"Symer","year":"2002","journal-title":"Cell"},{"key":"2022110309072920600_bib73","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/carcin\/22.3.403","article-title":"Nucleotide excision repair gene XPD polymorphisms and genetic predisposition to melanoma.","volume":"22","author":"Tomescu","year":"2001","journal-title":"Carcinogenesis"},{"key":"2022110309072920600_bib74","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0092-8674(92)90390-X","article-title":"ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne\u2019s syndrome and preferential repair of active genes.","volume":"71","author":"Troelstra","year":"1992","journal-title":"Cell"},{"key":"2022110309072920600_bib75","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200401056","article-title":"DNA damage stabilizes interaction of CSB with the transcription elongation machinery.","volume":"166","author":"van den Boom","year":"2004","journal-title":"J. Cell Biol."},{"key":"2022110309072920600_bib76","doi-asserted-by":"crossref","first-page":"a012625","DOI":"10.1101\/cshperspect.a012625","article-title":"Mammalian transcription-coupled excision repair.","volume":"5","author":"Vermeulen","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2022110309072920600_bib77","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1097-2765(01)00281-7","article-title":"Sequential assembly of the nucleotide excision repair factors in vivo.","volume":"8","author":"Volker","year":"2001","journal-title":"Mol. Cell"},{"key":"2022110309072920600_bib78","doi-asserted-by":"crossref","first-page":"e19672","DOI":"10.1371\/journal.pone.0019672","article-title":"Evolutionary conservation of the functional modularity of primate and murine LINE-1 elements.","volume":"6","author":"Wagstaff","year":"2011","journal-title":"PLoS One"},{"key":"2022110309072920600_bib79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1759-8753-1-22","article-title":"Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics.","volume":"1","author":"Wallace","year":"2010","journal-title":"Mob. DNA"},{"key":"2022110309072920600_bib80","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1759-8753-4-10","article-title":"Cell division promotes efficient retrotransposition in a stable L1 reporter cell line.","volume":"4","author":"Xie","year":"2013","journal-title":"Mob. DNA"},{"key":"2022110309072920600_bib81","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ajpa.20722","article-title":"Mobile DNA elements in primate and human evolution.","author":"Xing","year":"2007","journal-title":"Am. J. Phys. Anthropol."},{"key":"2022110309072920600_bib82","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1756-8722-4-17","article-title":"Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer.","volume":"4","author":"Xu","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"2022110309072920600_bib83","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1093\/nar\/gng068","article-title":"T-linker-specific ligation PCR (T-linker PCR): an advanced PCR technique for chromosome walking or for isolation of tagged DNA ends.","volume":"31","author":"Yuanxin","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2022110309072920600_bib84","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S1097-2765(03)00478-7","article-title":"ERCC1\/XPF removes the 3\u2032 overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.","volume":"12","author":"Zhu","year":"2003","journal-title":"Mol. Cell"}],"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/205\/1\/139\/46770118\/genetics0139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/205\/1\/139\/46770118\/genetics0139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T09:12:15Z","timestamp":1667466735000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/205\/1\/139\/6095575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":84,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,1]]},"published-print":{"date-parts":[[2017,1,1]]}},"URL":"https:\/\/doi.org\/10.1534\/genetics.116.188680","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,1,1]]},"published":{"date-parts":[[2017,1,1]]}}}