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This sensitivity is not a result of URA3 disruption because the phenotype was not restored after URA3 reintroduction. Rather, we found that homozygosis of a short region of chromosome 3R (Chr3R), which is naturally heterozygous in the MMS-resistant-related strains CAF4-2 and CAF2-1, confers MMS sensitivity and modulates growth polarization in response to MMS. Furthermore, induction of homozygosity in this region in CAF2-1 or CAF4-2 resulted in MMS sensitivity. We identified 11 genes by SNP\/comparative genomic hybridization containing only the a alleles in all the MMS-sensitive strains. Four candidate genes, SNF5, POL1, orf19.5854.1, and MBP1, were analyzed by generating hemizygous configurations in CAF2-1 and CAF4-2 for each allele of all four genes. Only hemizygous MBP1a\/mbp1b::SAT1-FLIP strains became MMS sensitive, indicating that MBP1a in the homo- or hemizygosis state was sufficient to account for the MMS-sensitive phenotype. In yeast, Mbp1 regulates G1\/S genes involved in DNA repair. A second region of homozygosis on Chr2L increased MMS sensitivity in CAI4 (Chr3R homozygous) but not CAF4-2 (Chr3R heterozygous). This is the first example of sign epistasis in C. albicans.<\/jats:p>","DOI":"10.1534\/genetics.116.189274","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T07:50:43Z","timestamp":1463989843000},"page":"1161-1176","source":"Crossref","is-referenced-by-count":30,"title":["Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"203","author":[{"given":"Toni","family":"Ciudad","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas , \u00c1rea Microbiolog\u00eda, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meleah","family":"Hickman","sequence":"additional","affiliation":[{"name":"Department of Genetics , Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bellido","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas , \u00c1rea Microbiolog\u00eda, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Genetics , Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455"},{"name":"Department of Microbiology and Biotechnology , George S. 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