{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:07:34Z","timestamp":1761808054988},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Determination of luminal diameter is critical to the function of small single-celled tubes. A series of EXC proteins, including EXC-1, prevent swelling of the tubular excretory canals in Caenorhabditis elegans. In this study, cloning of exc-1 reveals it to encode a homolog of mammalian IRG proteins, which play roles in immune response and autophagy and are associated with Crohn\u2019s disease. Mutants in exc-1 accumulate early endosomes, lack recycling endosomes, and exhibit abnormal apical cytoskeletal structure in regions of enlarged tubules. EXC-1 interacts genetically with two other EXC proteins that also affect endosomal trafficking. In yeast two-hybrid assays, wild-type and putative constitutively active EXC-1 binds to the LIM-domain protein EXC-9, whose homolog, cysteine-rich intestinal protein, is enriched in mammalian intestine. These results suggest a model for IRG function in forming and maintaining apical tubule structure via regulation of endosomal recycling.<\/jats:p>","DOI":"10.1534\/genetics.116.192559","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T14:38:34Z","timestamp":1466692714000},"page":"1789-1806","source":"Crossref","is-referenced-by-count":12,"title":["Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"203","author":[{"given":"Kelly A","family":"Grussendorf","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045"},{"name":"Department of Biological Sciences, Minnesota State University, Mankato, Minnesota 56001"},{"name":"Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher 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