{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:20:03Z","timestamp":1791350403701,"version":"4.3.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The conservation of sleep among animals suggests that this behavior serves an important adaptive function; however, a unifying function for and genetic.....<\/jats:p><jats:p>Stress-induced sleep (SIS) in Caenorhabditis elegans is important for restoration of cellular homeostasis and is a useful model to study the function and regulation of sleep. SIS is triggered when epidermal growth factor (EGF) activates the ALA neuron, which then releases neuropeptides to promote sleep. To further understand this behavior, we established a new model of SIS using irradiation by ultraviolet C (UVC) light. While UVC irradiation requires ALA signaling and leads to a sleep state similar to that induced by heat and other stressors, it does not induce the proteostatic stress seen with heat exposure. Based on the known genotoxic effects of UVC irradiation, we tested two genes, atl-1 and cep-1, which encode proteins that act in the DNA damage response pathway. Loss-of-function mutants of atl-1 had no defect in UVC-induced SIS but a partial loss-of-function mutant of cep-1, gk138, had decreased movement quiescence following UVC irradiation. Germline ablation experiments and tissue-specific RNA interference experiments showed that cep-1 is required somatically in neurons for its effect on SIS. The cep-1(gk138) mutant suppressed body movement quiescence controlled by EGF, indicating that CEP-1 acts downstream or in parallel to ALA activation to promote quiescence in response to ultraviolet light.<\/jats:p>","DOI":"10.1534\/genetics.117.300070","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T00:40:23Z","timestamp":1501288823000},"page":"571-582","source":"Crossref","is-referenced-by-count":64,"title":["Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in<i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"207","author":[{"given":"Hilary K","family":"DeBardeleben","sequence":"first","affiliation":[{"name":"Department of Neurology , Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey E","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Neurology , Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"},{"name":"Center for Sleep and Circadian Neurobiology , Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P","family":"Nessel","sequence":"additional","affiliation":[{"name":"Department of Neurology , Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Raizen","sequence":"additional","affiliation":[{"name":"Department of Neurology , Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/gerona\/62.9.951","article-title":"Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.","volume":"62","author":"Arum","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1242\/dev.116.3.755","article-title":"Characterization of a germ-line proliferation mutation in C. elegans.","volume":"116","author":"Beanan","year":"1992","journal-title":"Development"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1534\/genetics.106.061580","article-title":"Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.","volume":"174","author":"Benedetti","year":"2006","journal-title":"Genetics"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.exger.2014.02.002","article-title":"The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?","volume":"56","author":"Bennett","year":"2014","journal-title":"Exp. Gerontol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neuron.2014.12.061","article-title":"Light and hydrogen peroxide inhibit C. elegans feeding through gustatory receptor orthologs and pharyngeal neurons.","volume":"85","author":"Bhatla","year":"2015","journal-title":"Neuron"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0022-2836(69)90288-5","article-title":"A complementation analysis of the restriction and modification of DNA in Escherichia coli.","volume":"41","author":"Boyer","year":"1969","journal-title":"J. Mol. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans.","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"27393","DOI":"10.1016\/S0021-9258(19)61523-1","article-title":"Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae.","volume":"275","author":"Cabiscol","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nmeth.1463","article-title":"Enhanced neuronal RNAi in C. elegans using SID-1.","volume":"7","author":"Calixto","year":"2010","journal-title":"Nat. Methods"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"12569","DOI":"10.1523\/JNEUROSCI.1251-13.2013","article-title":"p63 regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent behavior.","volume":"33","author":"Cancino","year":"2013","journal-title":"J. Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-642-56348-5_4","article-title":"The small heat shock proteins of the nematode Caenorhabditis elegans: structure, regulation and biology.","volume":"28","author":"Candido","year":"2002","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"15512","DOI":"10.1073\/pnas.0403369101","article-title":"Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.","volume":"101","author":"Chao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4939-2842-2_14","article-title":"An imaging system for C. elegans behavior.","volume":"1327","author":"Churgin","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"e26652","DOI":"10.7554\/eLife.26652","article-title":"Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging.","volume":"6","author":"Churgin","year":"2017","journal-title":"Elife"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1371\/journal.pbio.0060216","article-title":"Is sleep essential?","volume":"6","author":"Cirelli","year":"2008","journal-title":"PLoS Biol."},{"key":"2023030913453317600_","doi-asserted-by":"publisher","DOI":"10.1113\/JP273009","article-title":"A mechanism for sickness sleep: lessons from invertebrates.","author":"Davis","year":"2016","journal-title":"J. Physiol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"8408","DOI":"10.1523\/JNEUROSCI.15-12-08408.1995","article-title":"Mutations in the Caenorhabditis elegans Na,K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function.","volume":"15","author":"Davis","year":"1995","journal-title":"J. Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng1396","article-title":"Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.","volume":"36","author":"Deng","year":"2004","journal-title":"Nat. Genet."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1126\/science.1065486","article-title":"Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.","volume":"294","author":"Derry","year":"2001","journal-title":"Science"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/B978-0-12-394620-1.00006-0","article-title":"Laser microsurgery in Caenorhabditis elegans.","volume":"107","author":"Fang-Yen","year":"2012","journal-title":"Methods Cell Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/35042517","article-title":"Functional genomic analysis of C. elegans chromosome I by systematic RNA interference.","volume":"408","author":"Fraser","year":"2000","journal-title":"Nature"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1534\/genetics.115.183038","article-title":"A conserved GEF for rho-family GTPases acts in an EGF signaling pathway to promote sleep-like quiescence in Caenorhabditis elegans.","volume":"202","author":"Fry","year":"2016","journal-title":"Genetics"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1534\/genetics.104.028423","article-title":"The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans.","volume":"168","author":"Hajdu-Cronin","year":"2004","journal-title":"Genetics"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/cncr.21364","article-title":"Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer.","volume":"104","author":"Hickok","year":"2005","journal-title":"Cancer"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.cub.2014.08.040","article-title":"Cellular stress induces a protective sleep-like state in C. elegans.","volume":"24","author":"Hill","year":"2014","journal-title":"Curr. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/sj.onc.1210263","article-title":"Coping with stress: multiple ways to activate p53.","volume":"26","author":"Horn","year":"2007","journal-title":"Oncogene"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrn2576","article-title":"How (and why) the immune system makes us sleep.","volume":"10","author":"Imeri","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00002820-199410000-00001","article-title":"The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy. A comparison with the fatigue experienced by healthy individuals.","volume":"17","author":"Irvine","year":"1994","journal-title":"Cancer Nurs."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1523\/JNEUROSCI.23-06-02122.2003","article-title":"The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions.","volume":"23","author":"Jacob","year":"2003","journal-title":"J. Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/1097-0142(20000915)89:6<1322::AID-CNCR18>3.0.CO;2-D","article-title":"Quality of life changes during conformal radiation therapy for prostate carcinoma.","volume":"89","author":"Janda","year":"2000","journal-title":"Cancer"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"27021","DOI":"10.1016\/S0021-9258(18)47120-7","article-title":"Combinatorial structure of a body muscle-specific transcriptional enhancer in Caenorhabditis elegans.","volume":"269","author":"Jantsch-Plunger","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/bfgp\/els047","article-title":"The TP53 signaling network in mammals and worms.","volume":"12","author":"Jolliffe","year":"2013","journal-title":"Brief. Funct. Genomics"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12035-011-8172-6","article-title":"p73: a multifunctional protein in neurobiology.","volume":"43","author":"Killick","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jpainsymman.2011.10.020","article-title":"Trajectories and predictors of symptom occurrence, severity, and distress in prostate cancer patients undergoing radiation therapy.","volume":"44","author":"Knapp","year":"2012","journal-title":"J. Pain Symptom Manage."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1091\/mbc.3.11.1199","article-title":"Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.","volume":"3","author":"Kodoyianni","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ccr.2005.03.024","article-title":"Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.","volume":"7","author":"Lackner","year":"2005","journal-title":"Cancer Cell"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbi.2014.12.028","article-title":"FMRFamide signaling promotes stress-induced sleep in Drosophila.","volume":"47","author":"Lenz","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1379\/1466-1268(1999)004<0235:DOOSRI>2.3.CO;2","article-title":"Direct observation of stress response in Caenorhabditis elegans using a reporter transgene.","volume":"4","author":"Link","year":"1999","journal-title":"Cell Stress Chaperones"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nn.2540","article-title":"C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.","volume":"13","author":"Liu","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.cub.2016.03.036","article-title":"The p53-like protein CEP-1 is required for meiotic fidelity in C. elegans.","volume":"26","author":"Mateo","year":"2016","journal-title":"Curr. Biol."},{"key":"2023030913453317600_","unstructured":"Mayo Clinic Staff, 2014\u2003Diseases and Conditions: Sunburn. Available at: http:\/\/www.mayoclinic.org\/diseases-conditions\/sunburn\/basics\/definition\/con-20031065. Accessed May 1, 2016."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/(SICI)1520-6823(1999)7:3<178::AID-ROI7>3.0.CO;2-0","article-title":"Prospective study of fatigue in localized prostate cancer patients undergoing radiotherapy.","volume":"7","author":"Monga","year":"1999","journal-title":"Radiat. Oncol. Investig."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1682\/JRRD.2004.06.0071","article-title":"Longitudinal study of quality of life in patients with localized prostate cancer undergoing radiotherapy.","volume":"42","author":"Monga","year":"2005","journal-title":"J. Rehabil. Res. Dev."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1534\/genetics.108.090704","article-title":"Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.","volume":"180","author":"Mori","year":"2008","journal-title":"Genetics"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1101\/gad.12.24.3788","article-title":"Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.","volume":"12","author":"Morimoto","year":"1998","journal-title":"Genes Dev."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.cub.2016.07.048","article-title":"C. elegans stress-induced sleep emerges from the collective action of multiple neuropeptides.","volume":"26","author":"Nath","year":"2016","journal-title":"Curr. Biol."},{"key":"2023030913453317600_"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.cub.2014.08.037","article-title":"FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans.","volume":"24","author":"Nelson","year":"2014","journal-title":"Curr. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1242\/dev.127.15.3361","article-title":"The homeodomain protein CePHOX2\/CEH-17 controls antero-posterior axonal growth in C. elegans.","volume":"127","author":"Pujol","year":"2000","journal-title":"Development"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbr.2014.11.036","article-title":"Environmental heat stress enhances mental fatigue during sustained attention task performing: evidence from an ASL perfusion study.","volume":"280","author":"Qian","year":"2015","journal-title":"Behav. Brain Res."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature06535","article-title":"Lethargus is a Caenorhabditis elegans sleep-like state.","volume":"451","author":"Raizen","year":"2008","journal-title":"Nature"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","unstructured":"Raizen, D., B.-M. Song, N. Trojanowski, and Y.-J. You, 2012\u2003Methods for measuring pharyngeal behaviors (December 18, 2012), WormBook, ed. The C. elegans Research Community, WormBook, doi\/10.1895\/wormbook.1.154.1, http:\/\/www.wormbook.org.10.1895\/wormbook.1.154.1","DOI":"10.1895\/wormbook.1.154.1"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1534\/g3.115.021899","article-title":"Caenorhabditis elegans glp-4 encodes a valyl aminoacyl tRNA synthetase.","volume":"5","author":"Rastogi","year":"2015","journal-title":"G3"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/ng1608","article-title":"A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.","volume":"37","author":"Rea","year":"2005","journal-title":"Nat. Genet."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1101\/gr.2505604","article-title":"Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.","volume":"14","author":"Rual","year":"2004","journal-title":"Genome Res."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neubiorev.2014.08.001","article-title":"The energy allocation function of sleep: a unifying theory of sleep, torpor, and continuous wakefulness.","volume":"47","author":"Schmidt","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/S0960-9822(01)00534-6","article-title":"C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis.","volume":"11","author":"Schumacher","year":"2001","journal-title":"Curr. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2004.12.009","article-title":"Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.","volume":"120","author":"Schumacher","year":"2005","journal-title":"Cell"},{"key":"2023030913453317600_","first-page":"893","article-title":"Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans","volume":"107","author":"Shen","year":"2001","journal-title":"Dev. Cell"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuron.2015.07.031","article-title":"Regulatory logic of pan-neuronal gene expression in C. elegans.","volume":"87","author":"Stefanakis","year":"2015","journal-title":"Neuron"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3181\/00379727-203-43590","article-title":"Sleep as a prognostic indicator during infectious disease in rabbits.","volume":"203","author":"Toth","year":"1993","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tins.2015.12.005","article-title":"Call it worm sleep.","volume":"39","author":"Trojanowski","year":"2016","journal-title":"Trends Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"14571","DOI":"10.1523\/JNEUROSCI.1369-15.2015","article-title":"Distinct mechanisms underlie quiescence during two Caenorhabditis elegans sleep-like states.","volume":"35","author":"Trojanowski","year":"2015","journal-title":"J. Neurosci."},{"key":"2023030913453317600_","volume-title":"Ultraviolet Radiation: An Authoritative Scientific Review of Environmental and Health Effects of UV, with Reference to Global Ozone Layer Depletion","author":"United Nations Environment Programme","year":"1994"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1083\/jcb.200203086","article-title":"A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.","volume":"158","author":"Urano","year":"2002","journal-title":"J. Cell Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nn1981","article-title":"Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans.","volume":"10","author":"Van Buskirk","year":"2007","journal-title":"Nat. Neurosci."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.cub.2012.05.032","article-title":"Report ultraviolet light provides a major input to non-image-forming light detection in mice.","volume":"22","author":"Van Oosterhout","year":"2012","journal-title":"Curr. Biol."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/cdd.2012.69","article-title":"Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans.","volume":"19","author":"Vermezovic","year":"2012","journal-title":"Cell Death Differ."},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbadis.2013.12.015","article-title":"p53 and mitochondrial function in neurons.","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2023030913453317600_","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/genetics\/149.3.1323","article-title":"A new marker for mosaic analysis in Caenorhabditis elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis.","volume":"149","author":"Yochem","year":"1998","journal-title":"Genetics"}],"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/207\/2\/571\/49472595\/genetics0571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/207\/2\/571\/49472595\/genetics0571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T19:10:52Z","timestamp":1692904252000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/207\/2\/571\/5930768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,7,27]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1534\/genetics.117.300070","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10,1]]},"published":{"date-parts":[[2017,7,27]]}}}