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In comparison, relatively little is known about how new telomeres are constructed on broken chromosomes in organisms that do not use telomerase. Chromosome healing was studied in somatic and germline cells of Drosophila melanogaster, a nontelomerase species. We observed, for the first time, that broken chromosomes can be healed in somatic cells. In addition, overexpression of the telomere cap component Hiphop increased the survival of somatic cells with broken chromosomes, while the cap component HP1 did not, and overexpression of the cap protein HOAP decreased their survival. In the male germline, Hiphop overexpression greatly increased the transmission of healed chromosomes. These results indicate that Hiphop can stimulate healing of a chromosome break. We suggest that this reflects a unique function of Hiphop: it is capable of seeding formation of a new telomeric cap on a chromosome end that lacks a telomere.<\/jats:p>","DOI":"10.1534\/genetics.117.300317","type":"journal-article","created":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T00:25:15Z","timestamp":1506212715000},"page":"949-959","source":"Crossref","is-referenced-by-count":17,"title":["Chromosome Healing Is Promoted by the Telomere Cap Component Hiphop in<i>Drosophila<\/i>"],"prefix":"10.1093","volume":"207","author":[{"given":"Rebeccah L","family":"Kurzhals","sequence":"first","affiliation":[{"name":"Department of Biology , Southeast Missouri State University, Cape Girardeau, Missouri 63701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fanti","sequence":"additional","affiliation":[{"name":"Pasteur Institute , Cenci-Bolognetti Foundation and Department of Biology and Biotechnology, University of Rome \u201cLa Sapienza,\u201d 00185, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C Gonzalez","family":"Ebsen","sequence":"additional","affiliation":[{"name":"Department of Biology , Southeast Missouri State University, Cape Girardeau, Missouri 63701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yikang S","family":"Rong","sequence":"additional","affiliation":[{"name":"School of Life Sciences , Sun Yat-Sen University, Guangzho, 510275 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Pimpinelli","sequence":"additional","affiliation":[{"name":"Pasteur Institute , Cenci-Bolognetti Foundation and Department of Biology and Biotechnology, University of Rome \u201cLa Sapienza,\u201d 00185, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent G","family":"Golic","sequence":"additional","affiliation":[{"name":"Department of Biology , University of Utah, Salt Lake City, Utah 8411"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"2022110315395230100_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/genetics\/148.2.775","article-title":"The transmission of fragmented chromosomes in Drosophila melanogaster.","volume":"148","author":"Ahmad","year":"1998","journal-title":"Genetics"},{"key":"2022110315395230100_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/genetics\/151.3.1041","article-title":"Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis.","volume":"151","author":"Ahmad","year":"1999","journal-title":"Genetics"},{"key":"2022110315395230100_bib3","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/nar\/15.4.1717","article-title":"Telomeric site position heterogeneity in macronuclear DNA of Paramecium primaurelia.","volume":"15","author":"Baroin","year":"1987","journal-title":"Nucleic Acids Res."},{"key":"2022110315395230100_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1534\/genetics.112.138818","article-title":"Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline.","volume":"191","author":"Beaucher","year":"2012","journal-title":"Genetics"},{"key":"2022110315395230100_bib5","author":"Beumer","year":"1997"},{"key":"2022110315395230100_bib6","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cub.2004.06.063","article-title":"Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance.","volume":"14","author":"Bi","year":"2004","journal-title":"Curr. 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