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In Escherichia coli, several gene products have been proposed to be involved in cross-link repair based on the hypersensitivity of mutants to cross-linking agents. However, cross-linking agents induce several forms of DNA damage, making it challenging to attribute mutant hypersensitivity specifically to interstrand cross-links. To address this, we compared the survival of UVA-irradiated repair mutants in the presence of 8-methoxypsoralen\u2014which forms interstrand cross-links and monoadducts\u2014to that of angelicin\u2014a congener forming only monoadducts. We show that incision by nucleotide excision repair is not required for resistance to interstrand cross-links. In addition, neither RecN nor DNA polymerases II, IV, or V is required for interstrand cross-link survival, arguing against models that involve critical roles for double-strand break repair or translesion synthesis in the repair process. Finally, estimates based on Southern analysis of DNA fragments in alkali agarose gels indicate that lethality occurs in wild-type cells at doses producing as few as one to two interstrand cross-links per genome. These observations suggest that E. coli may lack an efficient repair mechanism for this form of damage.<\/jats:p>","DOI":"10.1534\/genetics.118.301239","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T21:14:41Z","timestamp":1532553281000},"page":"99-112","source":"Crossref","is-referenced-by-count":10,"title":["Limited Capacity or Involvement of Excision Repair, Double-Strand Breaks, or Translesion Synthesis for Psoralen Cross-Link Repair in <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"210","author":[{"given":"Jessica M","family":"Cole","sequence":"first","affiliation":[{"name":"Department of Biology, Portland State University, Oregon 97201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jedidiah D","family":"Acott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charmain T","family":"Courcelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Courcelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,7,25]]},"reference":[{"key":"2022011201370065700_bib1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/BF02002841","article-title":"Conversion of psoralen DNA monoadducts in E. coli to interstrand DNA cross links by near UV light (320\u2013360 nm): inability of angelicin to form cross links, in vivo.","volume":"33","author":"Ashwood-Smith","year":"1977","journal-title":"Experientia"},{"key":"2022011201370065700_bib2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0009-2797(70)90054-2","article-title":"DNA repair after mustard gas alkylation by sensitive and resistant Yoshida sarcoma cells in vitro.","volume":"2","author":"Ball","year":"1970","journal-title":"Chem. 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