{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:13:18Z","timestamp":1780524798707,"version":"3.54.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The specification of tissue identity during embryonic development requires precise spatio-temporal coordination of gene expression. Many transcription factors required for the development of organs have been identified and their expression patterns are known; however, the mechanisms through which they coordinate gene expression in time remain poorly understood. Here, we show that hormone-induced transcription factor Blimp-1 participates in the temporal coordination of tubulogenesis in Drosophila melanogaster by regulating the expression of many genes involved in tube maturation. In particular, we demonstrate that Blimp-1 regulates the expression of genes involved in chitin deposition and F-actin organization. We show that Blimp-1 is involved in the temporal control of lumen maturation by regulating the beginning of chitin deposition. We also report that Blimp-1 represses a variety of genes involved in tracheal maturation. Finally, we reveal that the kinase Btk29A serves as a link between Blimp-1 transcriptional repression and apical extracellular matrix organization.<\/jats:p>","DOI":"10.1534\/genetics.118.301444","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T10:25:37Z","timestamp":1538648737000},"page":"653-663","source":"Crossref","is-referenced-by-count":11,"title":["Blimp-1 Mediates Tracheal Lumen Maturation in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1093","volume":"210","author":[{"given":"Arzu","family":"\u00d6zt\u00fcrk-\u00c7olak","sequence":"first","affiliation":[{"name":"Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, C. Baldiri Reixac 10, 08028 Barcelona, Spain"},{"name":"Institut de Recerca Biomedica de Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology, C. Baldiri Reixac 10, 08028 Barcelona, Spain, and"},{"name":"Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, C. Baldiri Reixac 10, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Stephan-Otto Attolini","sequence":"additional","affiliation":[{"name":"Institut de Recerca Biomedica de Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology, C. Baldiri Reixac 10, 08028 Barcelona, Spain, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Casanova","sequence":"additional","affiliation":[{"name":"Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, C. Baldiri Reixac 10, 08028 Barcelona, Spain"},{"name":"Institut de Recerca Biomedica de Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology, C. Baldiri Reixac 10, 08028 Barcelona, Spain, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia J","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, C. Baldiri Reixac 10, 08028 Barcelona, Spain"},{"name":"Institut de Recerca Biomedica de Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology, C. Baldiri Reixac 10, 08028 Barcelona, Spain, and"},{"name":"Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain and Institute of Biomedicine University of Barcelona (IBUB)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"2022011201370383400_bib1","doi-asserted-by":"publisher","first-page":"8739","DOI":"10.1128\/MCB.01304-07","article-title":"Drosophila Blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway.","volume":"27","author":"Agawa","year":"2007","journal-title":"Mol. Cell. 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