{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:25:17Z","timestamp":1792635917951,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During meiosis, formation of double-strand breaks (DSBs) and repair by homologous recombination between homologs creates crossovers (COs) that facilitate chromosome segregation. CO formation is tightly regulated to ensure the integrity of this process. The DNA damage response kinases, Ataxia-telangiectasia mutated (ATM) and RAD3-related (ATR) have emerged as key regulators of CO formation in yeast, flies, and mice, influencing DSB formation, repair pathway choice, and cell cycle progression. The molecular networks that ATM and ATR influence during meiosis are still being resolved in other organisms. Here, we show that Caenorhabditis elegans ATM and ATR homologs, ATM-1 and ATL-1 respectively, act at multiple steps in CO formation to ultimately ensure that COs are formed on all chromosomes. We show a role for ATM-1 in regulating the choice of repair template, biasing use of the homologous chromosome instead of the sister chromatid. Our data suggest a model in which ATM-1 and ATL-1 have antagonistic roles in very early repair processing, but are redundantly required for accumulation of the RAD-51 recombinase at DSB sites. We propose that these features of ATM-1 and ATL-1 ensure both CO formation on all chromosomes and accurate repair of additional DSBs.<\/jats:p>","DOI":"10.1534\/genetics.119.302193","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T21:44:08Z","timestamp":1556055848000},"page":"431-443","source":"Crossref","is-referenced-by-count":23,"title":["ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"212","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania 15213"},{"name":"Tsinghua University MD Program, School of Medicine, Tsinghua University, Haidian District, Beijing 100084, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L","family":"Yanowitz","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"2022011123565084100_bib1","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases.","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"2022011123565084100_bib2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/sj.embor.7401167","article-title":"BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.","volume":"9","author":"Adamo","year":"2008","journal-title":"EMBO Rep."},{"key":"2022011123565084100_bib3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005478","article-title":"Reduced crossover interference and increased ZMM-independent recombination in the absence of Tel1\/ATM.","volume":"11","author":"Anderson","year":"2015","journal-title":"PLoS Genet."},{"key":"2022011123565084100_bib4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia telangiectasia.","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"key":"2022011123565084100_bib5","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1242\/dev.125.20.4007","article-title":"Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.","volume":"125","author":"Barlow","year":"1998","journal-title":"Development"},{"key":"2022011123565084100_bib6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001028","article-title":"Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability.","volume":"6","author":"Bickel","year":"2010","journal-title":"PLoS Genet."},{"key":"2022011123565084100_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans.","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2022011123565084100_bib8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12013-008-9039-y","article-title":"Mechanisms of dealing with DNA damage-induced replication problems.","volume":"53","author":"Budzowska","year":"2009","journal-title":"Cell Biochem. 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