{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:27:56Z","timestamp":1784093276458,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hybrid male progeny from interspecies crosses are more prone to sterility or inviability than hybrid female progeny, and the male sterility and inviability often demonstrate parent-of-origin asymmetry. However, the underlying genetic mechanism of asymmetric sterility or inviability remains elusive. We previously established a genome-wide hybrid incompatibility (HI) landscape between Caenorhabditis briggsae and C. nigoni by phenotyping a large collection of C. nigoni strains each carrying a C. briggsae introgression. In this study, we systematically dissect the genetic mechanism of asymmetric sterility and inviability in both hybrid male and female progeny between the two species. Specifically, we performed reciprocal crosses between C. briggsae and different C. nigoni strains that each carry a GFP-labeled C. briggsae genomic fragment referred to as introgression, and scored the HI phenotypes in the F1 progeny. The aggregated introgressions cover 94.6% of the C. briggsae genome, including 100% of the X chromosome. Surprisingly, we observed that two C. briggsae \u00a0X fragments that produce C. nigoni male sterility as an introgression rescued hybrid F1 sterility in males fathered by C. briggsae. Subsequent backcrossing analyses indicated that a specific interaction between the X-linked interaction and one autosome introgression is required to rescue the hybrid male sterility. In addition, we identified another two C. briggsae genomic intervals on chromosomes II and IV that can rescue the inviability, but not the sterility, of hybrid F1 males fathered by C. nigoni, suggesting the involvement of differential epistatic interactions in the asymmetric hybrid male fertility and inviability. Importantly, backcrossing of the rescued sterile males with C. nigoni led to the isolation of a 1.1-Mb genomic interval that specifically interacts with an X-linked introgression, which is essential for hybrid male fertility. We further identified three C. briggsae genomic intervals on chromosome I, II, and III that produced inviability in all F1 progeny, dependent on or independent of the parent-of-origin. Taken together, we identified multiple independent interacting loci that are responsible for asymmetric hybrid male and female sterility, and inviability, which lays a foundation for their molecular characterization.<\/jats:p>","DOI":"10.1534\/genetics.119.302202","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T01:45:22Z","timestamp":1557279922000},"page":"801-813","source":"Crossref","is-referenced-by-count":29,"title":["Specific Interactions Between Autosome and <i>X<\/i> Chromosomes Cause Hybrid Male Sterility in <i>Caenorhabditis<\/i> Species"],"prefix":"10.1093","volume":"212","author":[{"given":"Yu","family":"Bi","sequence":"first","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiutao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Hong Kong, China"},{"name":"State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"2022011123565844600_bib1","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1186\/gb-2007-8-1-r11","article-title":"Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila.","volume":"8","author":"Bai","year":"2007","journal-title":"Genome Biol."},{"key":"2022011123565844600_bib2","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1558-5646.1992.tb02067.x","article-title":"Reproductive isolation in Rhabditidae (Nematoda: Secernentea); mechanisms that isolate six species of three genera.","volume":"46","author":"Baird","year":"1992","journal-title":"Evolution"},{"key":"2022011123565844600_bib3","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1126\/science.aan0621","article-title":"A maternal-effect selfish genetic element in Caenorhabditis elegans.","volume":"356","author":"Ben-David","year":"2017","journal-title":"Science"},{"key":"2022011123565844600_bib4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004993","article-title":"A Genome-wide hybrid incompatibility landscape between Caenorhabditis briggsae and C. nigoni.","volume":"11","author":"Bi","year":"2015","journal-title":"PLoS Genet."},{"key":"2022011123565844600_bib5","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1111\/evo.12708","article-title":"Gametic selection, developmental trajectories, and extrinsic heterogeneity in Haldane\u2019s rule.","volume":"69","author":"Bundus","year":"2015","journal-title":"Evolution"},{"key":"2022011123565844600_bib6","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41437-018-0069-y","article-title":"Genetic basis to hybrid inviability is more complex than hybrid male sterility in Caenorhabditis nematodes.","volume":"121","author":"Bundus","year":"2018","journal-title":"Heredity"},{"key":"2022011123565844600_bib7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1017\/S0016672300022643","article-title":"Genetic studies of three sibling species of Drosophila with relationship to theories of speciation.","volume":"46","author":"Coyne","year":"1985","journal-title":"Genet. 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