{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:03:31Z","timestamp":1783645411712,"version":"3.55.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Faithful segregation of mammalian X and Y chromosomes in male meiosis depends on pairing and recombination in a short interval of residual sequence homology known as the pseudoautosomal region (PAR)...<\/jats:p>\n                  <jats:p>Faithful segregation of homologous chromosomes at meiosis requires pairing and recombination. In taxa with dimorphic sex chromosomes, pairing between them in the heterogametic sex is limited to a narrow interval of residual sequence homology known as the pseudoautosomal region (PAR). Failure to form the obligate crossover in the PAR is associated with male infertility in house mice (Mus musculus) and humans. Yet despite this apparent functional constraint, the boundary and organization of the PAR is highly variable in mammals, and even between subspecies of mice. Here, we estimate the genetic map in a previously documented expansion of the PAR in the M. musculus castaneus subspecies and show that the local recombination rate is 100-fold higher than the autosomal background. We identify an independent shift in the PAR boundary in the M. musculus musculus subspecies and show that it involves a complex rearrangement, but still recombines in heterozygous males. Finally, we demonstrate pervasive copy-number variation at the PAR boundary in wild populations of M. m. domesticus, M. m. musculus, and M. m. castaneus. Our results suggest that the intensity of recombination activity in the PAR, coupled with relatively weak constraints on its sequence, permit the generation and maintenance of unusual levels of polymorphism in the population of unknown functional significance.<\/jats:p>","DOI":"10.1534\/genetics.119.302232","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T23:46:13Z","timestamp":1556322373000},"page":"469-487","source":"Crossref","is-referenced-by-count":28,"title":["Instability of the Pseudoautosomal Boundary in House Mice"],"prefix":"10.1093","volume":"212","author":[{"given":"Andrew P","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27514"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27514"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J","family":"Crowley","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27514"},{"name":"Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27514"},{"name":"Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pardo-Manuel de Villena","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27514"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"2022011123564403200_bib1","article-title":"Ensuring meiotic DNA break formation in the mouse pseudoautosomal region.","author":"Acquaviva","year":"2019","journal-title":"bioRxiv"},{"key":"2022011123564403200_bib2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1093\/bioinformatics\/btw576","article-title":"AKT: ancestry and kinship toolkit.","volume":"33","author":"Arthur","year":"2017","journal-title":"Bioinformatics"},{"key":"2022011123564403200_bib3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/BF00328392","article-title":"End association and segregation of the achiasmatic X and Y chromosomes of the sand rat, Psammomys obesus.","volume":"78","author":"Ashley","year":"1980","journal-title":"Chromosoma"},{"key":"2022011123564403200_bib4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004916","article-title":"PRDM9 drives evolutionary erosion of hotspots in Mus musculus through Haplotype-Specific initiation of meiotic recombination.","volume":"11","author":"Baker","year":"2015","journal-title":"PLoS Genet."},{"key":"2022011123564403200_bib5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. 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