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Yan et al. made knockout mutations in zebrafish...<\/jats:p><jats:p>Fetal mammalian testes secrete Anti-M\u00fcllerian hormone (Amh), which inhibits female reproductive tract (M\u00fcllerian duct) development. Amh also derives from mature mammalian ovarian follicles, which marks oocyte reserve and characterizes polycystic ovarian syndrome. Zebrafish (Danio rerio) lacks M\u00fcllerian ducts and the Amh receptor gene amhr2 but, curiously, retains amh. To discover the roles of Amh in the absence of M\u00fcllerian ducts and the ancestral receptor gene, we made amh null alleles in zebrafish. Results showed that normal amh prevents female-biased sex ratios. Adult male amh mutants had enormous testes, half of which contained immature oocytes, demonstrating that Amh regulates male germ cell accumulation and inhibits oocyte development or survival. Mutant males formed sperm ducts and some produced a few offspring. Young female mutants laid a few fertile eggs, so they also had functional sex ducts. Older amh mutants accumulated nonvitellogenic follicles in exceedingly large but sterile ovaries, showing that Amh helps control ovarian follicle maturation and proliferation. RNA-sequencing data partitioned juveniles at 21 days postfertilization (dpf) into two groups that each contained mutant and wild-type fish. Group21-1 upregulated ovary genes compared to Group21-2, which were likely developing as males. By 35 dpf, transcriptomes distinguished males from females and, within each sex, mutants from wild types. In adult mutants, ovaries greatly underexpressed granulosa and theca genes, and testes underexpressed Leydig cell genes. These results show that ancestral Amh functions included development of the gonadal soma in ovaries and testes and regulation of gamete proliferation and maturation. A major gap in our understanding is the identity of the gene encoding a zebrafish Amh receptor; we show here that the loss of amhr2 is associated with the breakpoint of a chromosome rearrangement shared among cyprinid fishes.<\/jats:p>","DOI":"10.1534\/genetics.119.302365","type":"journal-article","created":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T02:35:13Z","timestamp":1565404513000},"page":"529-553","source":"Crossref","is-referenced-by-count":72,"title":["A Hormone That Lost Its Receptor: Anti-M\u00fcllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination"],"prefix":"10.1093","volume":"213","author":[{"given":"Yi-Lin","family":"Yan","sequence":"first","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Batzel","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Titus","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Sydes","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Desvignes","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"BreMiller","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Draper","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology , University of California, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"Postlethwait","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience , University of Oregon, Eugene, Oregon 97403"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"2023031005254243700_","doi-asserted-by":"publisher","first-page":"34281","DOI":"10.1038\/srep34281","article-title":"Retinoic acid and meiosis induction in adult vs. embryonic gonads of medaka.","volume":"6","author":"Adolfi","year":"2016","journal-title":"Sci. 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