{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:36:36Z","timestamp":1784075796351,"version":"3.55.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hart characterizes a novel interaction between genetics and environmental stress on experience-dependent neuron remodeling and plasticity in Caenorhabditis elegans, defining an interplay between different forms of adolescent stress and the autism-associated gene neurexin...<\/jats:p>\n                  <jats:p>Neurexins are neuronal adhesion molecules important for synapse maturation, function, and plasticity. Neurexins have been genetically associated with neurodevelopmental disorders, including autism spectrum disorders (ASDs) and schizophrenia, but can have variable penetrance and phenotypic severity. Heritability studies indicate that a significant percentage of risk for ASD and schizophrenia includes environmental factors, highlighting a poorly understood interplay between genetic and environmental factors. The singular Caenorhabditis elegans ortholog of human neurexins, nrx-1, controls experience-dependent morphologic remodeling of a GABAergic neuron in adult males. Here, I show remodeling of this neuron\u2019s morphology in response to each of three environmental stressors (nutritional, heat, or genotoxic stress) when applied specifically during sexual maturation. Increased outgrowth of axon-like neurites following adolescent stress is the result of an altered morphologic plasticity in adulthood. Despite remodeling being induced by each of the three stressors, only nutritional stress affects downstream behavior and is dependent on neurexin\/nrx-1. Heat or genotoxic stress in adolescence does not alter behavior despite inducing GABAergic neuron remodeling, in a neurexin\/nrx-1 independent fashion. Starvation-induced remodeling is also dependent on neuroligin\/nlg-1, the canonical binding partner for neurexin\/nrx-1, and the transcription factors FOXO\/daf-16 and HSF1\/hsf-1. hsf-1 and daf-16, in addition, each have unique roles in remodeling induced by heat and UV stress. The differential molecular mechanisms underlying GABAergic neuron remodeling in response to different stressors, and the disparate effects of stressors on downstream behavior, are a paradigm for understanding how genetics, environmental exposures, and plasticity may contribute to brain dysfunction in ASDs and schizophrenia.<\/jats:p>","DOI":"10.1534\/genetics.119.302415","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T23:35:12Z","timestamp":1569540912000},"page":"1415-1430","source":"Crossref","is-referenced-by-count":20,"title":["Stress-Induced Neuron Remodeling Reveals Differential Interplay Between Neurexin and Environmental Factors in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"213","author":[{"given":"Michael P","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Genetics , University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"2023031009053087600_","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13229-017-0137-9","article-title":"Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.","volume":"8","author":"Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium","year":"2017","journal-title":"Mol. 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