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In the present work, Benner et al. molecularly map...<\/jats:p>\n                  <jats:p>Heterochromatin-mediated repression is essential for controlling the expression of transposons and for coordinated cell type-specific gene regulation. The small ovary (sov) locus was identified in a screen for female-sterile mutations in Drosophila melanogaster, and mutants show dramatic ovarian morphogenesis defects. We show that the null sov phenotype is lethal and map the locus to the uncharacterized gene CG14438, which encodes a nuclear zinc-finger protein that colocalizes with the essential Heterochromatin Protein 1 (HP1a). We demonstrate Sov functions to repress inappropriate gene expression in the ovary, silence transposons, and suppress position-effect variegation in the eye, suggesting a central role in heterochromatin stabilization.<\/jats:p>","DOI":"10.1534\/genetics.119.302590","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T23:34:10Z","timestamp":1569540850000},"page":"877-895","source":"Crossref","is-referenced-by-count":22,"title":["<i>Drosophila<\/i>\n                    Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary"],"prefix":"10.1093","volume":"213","author":[{"given":"Leif","family":"Benner","sequence":"first","affiliation":[{"name":"Section of Developmental Genomics , Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"},{"name":"Department of Biology , Johns Hopkins University, Baltimore, Maryland 21218"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias A","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Cell Biology , Emory University School of Medicine, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cale","family":"Whitworth","sequence":"additional","affiliation":[{"name":"Section of Developmental Genomics , Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"},{"name":"Department of Biology , Indiana University, Bloomington, Indiana 47405"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen J T","family":"Venken","sequence":"additional","affiliation":[{"name":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology"},{"name":"McNair Medical Institute at the Robert and Janice McNair Foundation"},{"name":"Dan L. 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