{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:58:29Z","timestamp":1773694709739,"version":"3.50.1"},"reference-count":30,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2015]]},"DOI":"10.1536\/ihj.14-386","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T18:03:52Z","timestamp":1434564232000},"page":"454-458","source":"Crossref","is-referenced-by-count":29,"title":["microRNA-340-5p Functions Downstream of Cardiotrophin-1 to Regulate Cardiac Eccentric Hypertrophy and Heart Failure via Target Gene Dystrophin"],"prefix":"10.1536","volume":"56","author":[{"given":"Jian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangguang","family":"An","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pixiong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Rosca MG, Tandler B, Hoppel CL. Mitochondria in cardiac hypertrophy and heart failure. J Mol Cell Cardiol 2013; 55: 31-41. (Review)","DOI":"10.1016\/j.yjmcc.2012.09.002"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ucar A, Gupta SK, Fiedler J, <i>et al<\/i>. The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun 2012; 3: 1078.","DOI":"10.1038\/ncomms2090"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. van Rooij E, Sutherland LB, Liu N, <i>et al<\/i>. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006; 103: 18255-60.","DOI":"10.1073\/pnas.0608791103"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Papageorgiou N, Tousoulis D, Androulakis E, <i>et al<\/i>. The role of microRNAs in cardiovascular disease. Curr Med Chem 2012; 19: 2605-10. (Review)","DOI":"10.2174\/092986712800493048"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Orenes-Pi\u00f1ero E, Montoro-Garc\u00eda S, Patel JV, Vald\u00e9s M, Mar\u00edn F, Lip GY. Role of microRNAs in cardiac remodelling: new insights and future perspectives. Int J Cardiol 2013; 167: 1651-9. (Review)","DOI":"10.1016\/j.ijcard.2012.09.120"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Jeong MH, Lee JS, Kim do H, Park WJ, Yang DK. Identification of novel microRNAs negatively regulating cardiac hypertrophy. Biochem Biophys Res Commun 2012; 428: 191-6.","DOI":"10.1016\/j.bbrc.2012.10.040"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Han M, Yang Z, Sayed D, <i>et al<\/i>. GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. Cardiovasc Res 2012; 93: 645-54.","DOI":"10.1093\/cvr\/cvs001"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kelly M, Bagnall RD, Peverill RE, <i>et al<\/i>. A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. J Mol Cell Cardiol 2011; 51: 848-54.","DOI":"10.1016\/j.yjmcc.2011.07.001"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Car\u00e8 A, Catalucci D, Felicetti F, <i>et al<\/i>. MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007; 13: 613-8.","DOI":"10.1038\/nm1582"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lin Z, Murtaza I, Wang K, Jiao J, Gao J, Li PF. miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci U S A 2009; 106: 12103-8.","DOI":"10.1073\/pnas.0811371106"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Zhu X, Wang H, Liu F, <i>et al<\/i>. Identification of micro-RNA networks in end-stage heart failure because of dilated cardiomyopathy. J Cell Mol Med 2013; 17: 1173-87.","DOI":"10.1111\/jcmm.12096"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ge Y, Pan S, Guan D, <i>et al<\/i>. MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways. Biochim Biophys Acta 2013; 1832: 1-10.","DOI":"10.1016\/j.bbadis.2012.09.004"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Brower GL, Levick SP, Janicki JS. Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. Am J Physiol Heart Circ Physiol 2007; 292: H3057-64.","DOI":"10.1152\/ajpheart.00447.2006"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Yanagawa B, Lovren F, Pan Y, <i>et al<\/i>. miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis. J Thorac Cardiovasc Surg 2012; 144: 256-62.","DOI":"10.1016\/j.jtcvs.2011.10.097"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. van Mil A, Grundmann S, Goumans MJ, <i>et al<\/i>. MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release. Cardiovasc Res 2012; 93: 655-65.","DOI":"10.1093\/cvr\/cvs003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Xiong D, Lee GH, Badorff C, <i>et al<\/i>. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med 2002; 8: 872-7.","DOI":"10.1038\/nm737"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Wollert KC, Taga T, Saito M, <i>et al<\/i>. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130\/ leukemia inhibitory factor receptor-dependent pathways. J Biol Chem 1996; 271: 9535-45.","DOI":"10.1074\/jbc.271.16.9535"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Zolk O, Ng LL, O\u2019Brien RJ, Weyand M, Eschenhagen T. Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. Circulation 2002; 106: 1442-6.","DOI":"10.1161\/01.CIR.0000033117.39335.DF"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Calabr\u00f2 P, Limongelli G, Riegler L, <i>et al<\/i>. Novel insights into the role of cardiotrophin-1 in cardiovascular diseases. J Mol Cell Cardiol 2009; 46: 142-8. (Review)","DOI":"10.1016\/j.yjmcc.2008.11.002"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Pan J, Fukuda K, Saito M, <i>et al<\/i>. Mechanical stretch activates the JAK\/STAT pathway in rat cardiomyocytes. Circ Res 1999; 84: 1127-36.","DOI":"10.1161\/01.RES.84.10.1127"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Rybakova IN, Patel JR, Ervasti JM. The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin. J Cell Biol 2000; 150: 1209-14.","DOI":"10.1083\/jcb.150.5.1209"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Badorff C, Lee GH, Lamphear BJ, <i>et al<\/i>. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med 1999; 5: 320-6.","DOI":"10.1038\/6543"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bristow MR, Long CS. Cardiotrophin-1 in heart failure. Circulation 2002; 106: 1430-2.","DOI":"10.1161\/01.CIR.0000034024.61382.42"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Tsutamoto T, Wada A, Maeda K, <i>et al<\/i>. Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy. J Am Coll Cardiol 2001; 38: 1485-90.","DOI":"10.1016\/S0735-1097(01)01576-5"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ruiz-Hurtado G, G\u00f3mez-Hurtado N, Fern\u00e1ndez-Velasco M, <i>et al<\/i>. Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes. Cardiovasc Res 2012; 96: 81-9.","DOI":"10.1093\/cvr\/cvs234"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Celik A, Sahin S, Koc F, <i>et al<\/i>. Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure. Med Sci Monit 2012; 18: CR25-31.","DOI":"10.12659\/MSM.882197"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Ravassa S, Beloqui O, Varo N, <i>et al<\/i>. Association of cardiotrophin-1 with left ventricular systolic properties in asymptomatic hypertensive patients. J Hypertens 2013; 31: 587-94.","DOI":"10.1097\/HJH.0b013e32835ca903"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Stejskal D, Ruzicka V. Cardiotrophin-1. Review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2008; 152: 9-19. (Review)","DOI":"10.5507\/bp.2008.002"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Scheuermann-Freestone M, Freestone NS, Langenickel T, H\u00f6hnel K, Dietz R, Willenbrock R. A new model of congestive heart failure in the mouse due to chronic volume overload. Eur J Heart Fail 2001; 3: 535-43.","DOI":"10.1016\/S1388-9842(01)00160-X"},{"key":"30","unstructured":"30. Jacobs PA, Hunt PA, Mayer M, Bart RD. Duchenne muscular dystrophy (DMD) in a female with an X\/autosome translocation: further evidence that the DMD locus is at Xp21. Am J Hum Genet 1981; 33: 513-8."}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T09:56:53Z","timestamp":1498211813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/56\/4\/56_14-386\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.14-386","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}