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Abnormalities of the coronary arteries, neural structures and conduction system of the heart observed postmortem in the eosinophilia-myalgia syndrome, with a discussion of comparative findings from the toxic oil syndrome. Trans Am Clin Climatol Assoc 1991; 102: 52-81."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc Res 2001; 52: 181-98. (Review)","DOI":"10.1016\/S0008-6363(01)00384-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Liu RX, Wang YL, Li HB, Wang NN, Bao MJ, Xu LY. Comparative study between original and traditional method in establishing a chronic sinus node damage model in rabbit. J Appl Physiol 2012; 113: 1802-8.","DOI":"10.1152\/japplphysiol.00480.2012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yan ZX, Stitz L, Heeg P, Pfaff E, Roth K. Infectivity of prion protein bound to stainless steel wires: a model for testing decontamination procedures for transmissible spongiform encephalopathies. Infect Control Hosp Epidemiol 2004; 25: 280-3.","DOI":"10.1086\/502392"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Tamai T, Seki T, Imamura M, <i>et al<\/i>. Percutaneous injection of a low-concentration alkaline solution targeting hepatocellular carcinoma. Oncol Rep 2000; 7: 719-23.","DOI":"10.3892\/or.7.4.719"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Cramer M, Hariman RJ, Boxer R, Hoffman BF. Electrograms from the canine sinoatrial pacemaker recorded in vitro and in situ. Am J Cardiol 1978; 42: 939-46.","DOI":"10.1016\/0002-9149(78)90679-3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Narula OS, Shantha N, Vasquez M, Towne WD, Linhart JW. A new method for measurement of sinoatrial conduction time. 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Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg 2004; 239: 1-11.","DOI":"10.1097\/01.sla.0000102989.54824.fc"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Pouladi MA, Morton AJ, Hayden MR. Choosing an animal model for the study of Huntington\u2019s disease. Nat Rev Neurosci 2013; 14: 708-21. (Review)","DOI":"10.1038\/nrn3570"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kurata Y, Matsuda H, Hisatome I, Shibamoto T. Regional difference in dynamical property of sinoatrial node pacemaking: role of na+ channel current. Biophys J 2008; 95: 951-77.","DOI":"10.1529\/biophysj.107.112854"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Boyett MR, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res 2000; 47: 658-87. (Review)","DOI":"10.1016\/S0008-6363(00)00135-8"},{"key":"23","unstructured":"23. Manolis AS, Dragazis I, Kapelakis I, Papadimitriou P, Sakellaris N. Transesophageal overdrive pacing: a simple and versatile tool. Hospital Chronicles 2013; 8: 143-5."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Qiao L, Xie L, Shi K, Zhou T, Hua Y, Liu H. Notch signaling change in pulmonary vascular remodeling in rats with pulmonary hypertension and its implication for therapeutic intervention. PLoS One 2012; 7: e51514.","DOI":"10.1371\/journal.pone.0051514"},{"key":"25","unstructured":"25. Saul JP. Transesophageal Atrial Recording and Pacing. In: Walsh EP, Saul JP, Triedman JK. <i>Cardiac Arrhythmias in Children and Young Adults with Congenital Heart Disease.<\/i> Philadelphia, PA: Lippincott Williams and Wilkins; 2001: 33-55."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Prevarskaya N, Skryma R, Bidaux G, Flourakis M, Shuba Y. Ion channels in death and differentiation of prostate cancer cells. Cell Death Differ 2007; 14: 1295-304. 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Can J Physiol Pharmacol 2001; 79: 963-76.","DOI":"10.1139\/y01-085"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Danzi S, Klein I. Thyroid hormone and the cardiovascular system. Med Clin North Am 2012; 96: 257-68. (Review)","DOI":"10.1016\/j.mcna.2012.01.006"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Catterall WA. Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 1992; 72: S15-48. (Review)","DOI":"10.1152\/physrev.1992.72.suppl_4.S15"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Brackenbury WJ, Isom LL. Na Channel <i>\u03b2<\/i> Subunits: Overachievers of the Ion Channel Family. Front Pharmacol 2011; 2: 53.","DOI":"10.3389\/fphar.2011.00053"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Butters TD, Aslanidi OV, Inada S, <i>et al<\/i>. Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. 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