{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:17:39Z","timestamp":1791206259694,"version":"4.1.0"},"reference-count":85,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2015]]},"DOI":"10.1536\/ihj.15-019","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T22:03:45Z","timestamp":1434578625000},"page":"365-371","source":"Crossref","is-referenced-by-count":23,"title":["MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism"],"prefix":"10.1536","volume":"56","author":[{"given":"Koh","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-97. (Review)","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-5. (Review)","DOI":"10.1038\/nature02871"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-54.","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993; 75: 855-62.","DOI":"10.1016\/0092-8674(93)90530-4"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.","DOI":"10.1016\/j.cell.2004.12.035"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19: 92-105.","DOI":"10.1101\/gr.082701.108"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kozomara A, Griffiths-Jones S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011; 39: D152-7.","DOI":"10.1093\/nar\/gkq1027"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Cheloufi S, Dos Santos CO, Chong MM, Hannon GJ. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 2010; 465: 584-9.","DOI":"10.1038\/nature09092"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Rottiers V, N\u00e4\u00e4r AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 2012; 13: 239-50. (Review)","DOI":"10.1038\/nrm3313"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-33. (Review)","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9: 102-14. (Review)","DOI":"10.1038\/nrg2290"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Moore KJ, Rayner KJ, Su\u00e1rez Y, Fern\u00e1ndez -Hernando C. microRNAs and cholesterol metabolism. Trends Endocrinol Metab 2010; 21: 699-706. (Review)","DOI":"10.1016\/j.tem.2010.08.008"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Norata GD, Sala F, Catapano AL, Fern\u00e1ndez-Hernando C. MicroRNAs and lipoproteins: a connection beyond atherosclerosis? Atherosclerosis 2013; 227: 209-15. (Review)","DOI":"10.1016\/j.atherosclerosis.2012.11.019"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Horie T, Ono K, Horiguchi M, <i>et al<\/i>. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci U S A 2010; 107: 17321-6.","DOI":"10.1073\/pnas.1008499107"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Najafi-Shoushtari SH, Kristo F, Li Y, <i>et al<\/i>. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 2010; 328: 1566-9.","DOI":"10.1126\/science.1189123"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Rayner KJ, Su\u00e1rez Y, D\u00e1valos A, <i>et al<\/i>. MiR-33 contributes to the regulation of cholesterol homeostasis. Science 2010; 328: 1570-3.","DOI":"10.1126\/science.1189862"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Esau C, Davis S, Murray SF, <i>et al<\/i>. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006; 3: 87-98.","DOI":"10.1016\/j.cmet.2006.01.005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Vickers KC, Landstreet SR, Levin MG, <i>et al<\/i>. MicroRNA-223 coordinates cholesterol homeostasis. Proc Natl Acad Sci U S A 2014; 111: 14518-23.","DOI":"10.1073\/pnas.1215767111"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Zhang B, Kawachi E, Matsunaga A, <i>et al<\/i>. Reactivity of direct assays for low-density lipoprotein (LDL) cholesterol toward charge-modified LDL in hypercholesterolemia. Circ J 2012; 76: 2241-8.","DOI":"10.1253\/circj.CJ-12-0381"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Cheng AY, Leiter LA. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Curr Opin Cardiol 2006; 21: 400-4. (Review)","DOI":"10.1097\/01.hco.0000231412.15049.fb"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Grundy SM, Cleeman JI, Merz CN, <i>et al<\/i>. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 2004; 44: 720-32. (Review)","DOI":"10.1016\/j.jacc.2004.07.001"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Cannon CP, Braunwald E, McCabe CH, <i>et al<\/i>. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004; 350: 1495-504.","DOI":"10.1056\/NEJMoa040583"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. LaRosa JC, Grundy SM, Waters DD, <i>et al<\/i>. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 2005; 352: 1425-35.","DOI":"10.1056\/NEJMoa050461"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Hirayama A, Honarpour N, Yoshida M, <i>et al<\/i>. Effects of evolocumab (AMG 145), a monoclonal antibody to PCSK9, in hypercholesterolemic, statin-treated Japanese patients at high cardiovascular risk--primary results from the phase 2 YUKAWA study. Circ J 2014; 78: 1073-82.","DOI":"10.1253\/circj.CJ-14-0130"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Zhang B, Kawachi E, Miura S, <i>et al<\/i>. Therapeutic approaches to the regulation of metabolism of high-density lipoprotein. Novel HDL-directed pharmacological intervention and exercise. Circ J 2013; 77: 2651-63. (Review)","DOI":"10.1253\/circj.CJ-12-1584"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Matsue Y, Matsumura A, Suzuki M, Hashimoto Y, Yoshida M. Differences in action of atorvastatin and ezetimibe in lowering low-density lipoprotein cholesterol and effect on endothelial function: randomized controlled trial. Circ J 2013; 77: 1791-8.","DOI":"10.1253\/circj.CJ-13-0033"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Chim SS, Shing TK, Hung EC, <i>et al<\/i>. Detection and characterization of placental microRNAs in maternal plasma. Clin Chem 2008; 54: 482-90.","DOI":"10.1373\/clinchem.2007.097972"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Widera C, Gupta SK, Lorenzen JM, <i>et al<\/i>. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome. J Mol Cell Cardiol 2011; 51: 872-5.","DOI":"10.1016\/j.yjmcc.2011.07.011"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Kuwabara Y, Ono K, Horie T, <i>et al<\/i>. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet 2011; 4: 446-54.","DOI":"10.1161\/CIRCGENETICS.110.958975"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Fichtlscherer S, De Rosa S, Fox H, <i>et al<\/i>. Circulating microRNAs in patients with coronary artery disease. Circ Res 2010; 107: 677-84.","DOI":"10.1161\/CIRCRESAHA.109.215566"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Tijsen AJ, Creemers EE, Moerland PD, <i>et al<\/i>. MiR423-5p as a circulating biomarker for heart failure. Circ Res 2010; 106: 1035-9.","DOI":"10.1161\/CIRCRESAHA.110.218297"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Li S, Zhu J, Zhang W, <i>et al<\/i>. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation 2011; 124: 175-84.","DOI":"10.1161\/CIRCULATIONAHA.110.012237"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Tan KS, Armugam A, Sepramaniam S, <i>et al<\/i>. Expression profile of MicroRNAs in young stroke patients. PLoS One 2009; 4: e7689.","DOI":"10.1371\/journal.pone.0007689"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Munehira Y, Ohnishi T, Kawamoto S, <i>et al<\/i>. Alpha1-syntrophin modulates turnover of ABCA1. J Biol Chem 2004; 279: 15091-5.","DOI":"10.1074\/jbc.M313436200"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Wang N, Chen W, Linsel-Nitschke P, <i>et al<\/i>. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest 2003; 111: 99-107.","DOI":"10.1172\/JCI200316808"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Marquart TJ, Allen RM, Ory DS, Bald\u00e1n A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci U S A 2010; 107: 12228-32.","DOI":"10.1073\/pnas.1005191107"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Gerin I, Clerbaux LA, Haumont O, <i>et al<\/i>. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem 2010; 285: 33652-61.","DOI":"10.1074\/jbc.M110.152090"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Brown MS, Ye J, Goldstein JL. Medicine. HDL miR-ed down by SREBP introns. Science 2010; 328: 1495-6.","DOI":"10.1126\/science.1192409"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Horie T, Nishino T, Baba O, <i>et al<\/i>. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep 2014; 4: 5312.","DOI":"10.1038\/srep05312"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997; 89: 331-40. (Review)","DOI":"10.1016\/S0092-8674(00)80213-5"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Horton JD, Shimomura I. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 1999; 10: 143-50. (Review)","DOI":"10.1097\/00041433-199904000-00008"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-31. (Review)","DOI":"10.1172\/JCI0215593"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Allen RM, Marquart TJ, Albert CJ, <i>et al<\/i>. miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. EMBO Mol Med 2012; 4: 882-95.","DOI":"10.1002\/emmm.201201228"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Rayner KJ, Sheedy FJ, Esau CC, <i>et al<\/i>. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest 2011; 121: 2921-31.","DOI":"10.1172\/JCI57275"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Horie T, Baba O, Kuwabara Y, <i>et al<\/i>. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE(-\/-) mice. J Am Heart Assoc 2012; 1: e003376.","DOI":"10.1161\/JAHA.112.003376"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Tang C, Liu Y, Kessler PS, Vaughan AM, Oram JF. The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem 2009; 284: 32336-43.","DOI":"10.1074\/jbc.M109.047472"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Ramirez CM, D\u00e1valos A, Goedeke L, <i>et al<\/i>. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol 2011; 31: 2707-14.","DOI":"10.1161\/ATVBAHA.111.232066"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Dietschy JM, Turley SD. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 2004; 45: 1375-97. (Review)","DOI":"10.1194\/jlr.R400004-JLR200"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Liu JP, Tang Y, Zhou S, Toh BH, McLean C, Li H. Cholesterol involvement in the pathogenesis of neurodegenerative diseases. Mol Cell Neurosci 2010; 43: 33-42. (Review)","DOI":"10.1016\/j.mcn.2009.07.013"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Wang N, Yvan-Charvet L, L\u00fctjohann D, <i>et al<\/i>. ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J 2008; 22: 1073-82.","DOI":"10.1096\/fj.07-9944com"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Mandolini C, Santovito D, Marcantonio P, <i>et al<\/i>. Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques. Nutr Metab Cardiovasc Dis 2015; 25: 202-9.","DOI":"10.1016\/j.numecd.2014.09.005"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Zhang Y, Edwards PA. FXR signaling in metabolic disease. FEBS Lett 2008; 582: 10-8. (Review)","DOI":"10.1016\/j.febslet.2007.11.015"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147-91. (Review)","DOI":"10.1152\/physrev.00010.2008"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Yang JS, Maurin T, Robine N, <i>et al<\/i>. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A 2010; 107: 15163-8.","DOI":"10.1073\/pnas.1006432107"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Kuwabara Y, Horie T, Baba O, <i>et al<\/i>. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1\/AMPK pathway. Circ Res 2015; 116: 279-88.","DOI":"10.1161\/CIRCRESAHA.116.304707"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. de Aguiar Vallim TQ, Tarling EJ, Kim T, <i>et al<\/i>. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res 2013; 112: 1602-12.","DOI":"10.1161\/CIRCRESAHA.112.300648"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Rasmussen KD, Simmini S, Abreu-Goodger C, <i>et al<\/i>. The miR-144\/451 locus is required for erythroid homeostasis. J Exp Med 2010; 207: 1351-8.","DOI":"10.1084\/jem.20100458"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Annema W, Dikkers A, Freark de Boer J, <i>et al<\/i>. ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma. J Lipid Res 2012; 53: 929-40.","DOI":"10.1194\/jlr.M020743"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Kang MH, Zhang LH, Wijesekara N, <i>et al<\/i>. Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145. Arterioscler Thromb Vasc Biol 2013; 33: 2724-32.","DOI":"10.1161\/ATVBAHA.113.302004"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Sachdeva M, Zhu S, Wu F, <i>et al<\/i>. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci U S A 2009; 106: 3207-12.","DOI":"10.1073\/pnas.0808042106"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009; 137: 647-58.","DOI":"10.1016\/j.cell.2009.02.038"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Bidzhekov K, Gan L, Denecke B, <i>et al<\/i>. microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans. Thromb Haemost 2012; 107: 619-25.","DOI":"10.1160\/TH11-09-0607"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Liu G, Huang Y, Lu X, <i>et al<\/i>. Identification and characteristics of microRNAs with altered expression patterns in a rat model of abdominal aortic aneurysms. Tohoku J Exp Med 2010; 222: 187-93.","DOI":"10.1620\/tjem.222.187"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Lv YC, Tang YY, Peng J, <i>et al<\/i>. MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis 2014; 236: 215-26.","DOI":"10.1016\/j.atherosclerosis.2014.07.005"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Gantier MP, Stunden HJ, McCoy CE, <i>et al<\/i>. A miR-19 regulon that controls NF-\u03baB signaling. Nucleic Acids Res 2012; 40: 8048-58.","DOI":"10.1093\/nar\/gks521"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Sloane JP, Thomas JA, Imrie SF, Easton DF, Powles RL. Morphological and immunohistological changes in the skin in allogeneic bone marrow recipients. J Clin Pathol 1984; 37: 919-30.","DOI":"10.1136\/jcp.37.8.919"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Pittman RC, Knecht TP, Rosenbaum MS, Taylor CA Jr. A nonendocytotic mechanism for the selective uptake of high density lipoprotein-associated cholesterol esters. J Biol Chem 1987; 262: 2443-50.","DOI":"10.1016\/S0021-9258(18)61524-8"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996; 271: 518-20.","DOI":"10.1126\/science.271.5248.518"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Azhar S, Leers-Sucheta S, Reaven E. Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and \u2018selective\u2019 pathway connection. Front Biosci 2003; 8: s998-1029. (Review)","DOI":"10.2741\/1165"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Azhar S, Nomoto A, Leers-Sucheta S, Reaven E. Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroidogenic cell model. J Lipid Res 1998; 39: 1616-28.","DOI":"10.1016\/S0022-2275(20)32191-X"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Hu Z, Shen WJ, Kraemer FB, Azhar S. MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells. Mol Cell Biol 2012; 32: 5035-45.","DOI":"10.1128\/MCB.01002-12"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Azhar S, Nomoto A, Reaven E. Hormonal regulation of adrenal microvillar channel formation. J Lipid Res 2002; 43: 861-71.","DOI":"10.1016\/S0022-2275(20)30459-4"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Johnnidis JB, Harris MH, Wheeler RT, <i>et al<\/i>. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 2008; 451: 1125-9.","DOI":"10.1038\/nature06607"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, Liu ZG. MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol 2010; 11: 799-805.","DOI":"10.1038\/ni.1918"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Vickers KC, Shoucri BM, Levin MG, <i>et al<\/i>. MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia. Hepatology 2013; 57: 533-42.","DOI":"10.1002\/hep.25846"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Wang L, Jia XJ, Jiang HJ, <i>et al<\/i>. MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition. Mol Cell Biol 2013; 33: 1956-64.","DOI":"10.1128\/MCB.01580-12"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Chen X, Ba Y, Ma L, <i>et al<\/i>. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008; 18: 9971006.","DOI":"10.1038\/cr.2008.282"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Mitchell PS, Parkin RK, Kroh EM, <i>et al<\/i>. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008; 105: 10513-8.","DOI":"10.1073\/pnas.0804549105"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Valadi H, Ekstr\u00f6m K, Bossios A, Sj\u00f6strand M, Lee JJ, L\u00f6tvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654-9.","DOI":"10.1038\/ncb1596"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Hunter MP, Ismail N, Zhang X, <i>et al<\/i>. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008; 3: e3694.","DOI":"10.1371\/journal.pone.0003694"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Turchinovich A, Weiz L, Burwinkel B. Extracellular miRNAs: the mystery of their origin and function. Trends Biochem Sci 2012; 37: 460-5.","DOI":"10.1016\/j.tibs.2012.08.003"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Arroyo JD, Chevillet JR, Kroh EM, <i>et al<\/i>. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 2011; 108: 5003-8.","DOI":"10.1073\/pnas.1019055108"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011; 13: 423-33.","DOI":"10.1038\/ncb2210"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Tabet F, Vickers KC, Cuesta Torres LF, <i>et al<\/i>. HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. Nat Commun 2014; 5: 3292.","DOI":"10.1038\/ncomms4292"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Wagner J, Riwanto M, Besler C, <i>et al<\/i>. Characterization of levels and cellular transfer of circulating lipoprotein-bound microRNAs. Arterioscler Thromb Vasc Biol 2013; 33: 1392-400.","DOI":"10.1161\/ATVBAHA.112.300741"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T20:47:43Z","timestamp":1652474863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/56\/4\/56_15-019\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.15-019","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}