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Gill R, Kuriakose R, Gertz ZM, Salloum FN, Xi L, Kukreja RC. Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance. Mol Cell Biochem 2015; 402: 41-9. (Review)"},{"key":"2","unstructured":"2. Kasanuki H, Honda T, Haze K, <i>et al<\/i>. A large-scale prospective cohort study on the current status of therapeutic modalities for acute myocardial infarction in Japan: rationale and initial results of the HIJAMI Registry. Am Heart J 2005; 150: 411-8."},{"key":"3","unstructured":"3. Takii T, Yasuda S, Takahashi J, <i>et al<\/i>. Trends in acute myocardial infarction incidence and mortality over 30 years in Japan: report from the MIYAGI-AMI Registry Study. Circ J 2010; 74: 93-100."},{"key":"4","unstructured":"4. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 2010; 121: 2437-45. (Review)"},{"key":"5","unstructured":"5. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990; 81: 1161-72. (Review)"},{"key":"6","unstructured":"6. Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res 2012; 110: 159-73. (Review)"},{"key":"7","unstructured":"7. Swirski FK, Nahrendorf M, Etzrodt M, <i>et al<\/i>. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 2009; 325: 612-6."},{"key":"8","unstructured":"8. Robbins CS, Chudnovskiy A, Rauch PJ, <i>et al<\/i>. Extramedullary hematopoiesis generates Ly-6C (high) monocytes that infiltrate atherosclerotic lesions. Circulation 2012; 125: 364-74."},{"key":"9","unstructured":"9. Leuschner F, Panizzi P, Chico-Calero I, <i>et al<\/i>. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res 2010; 107: 1364-73."},{"key":"10","unstructured":"10. Nahrendorf M, Swirski FK, Aikawa E, <i>et al<\/i>. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 3037-47."},{"key":"11","unstructured":"11. Lu W, Zhang Z, Fu C, Ma G. Intermediate monocytes lead to enhanced myocardial remodelling in STEMI patients with diabetes. Int Heart J 2015; 56: 22-8."},{"key":"12","unstructured":"12. Panizzi P, Swirski FK, Figueiredo JL, <i>et al<\/i>. Impaired infarct healing in atherosclerotic mice with Ly-6C (hi) monocytosis. J Am Coll Cardiol 2010; 55: 1629-38."},{"key":"13","unstructured":"13. van Amerongen MJ, Harmsen MC, van Rooijen N, Petersen AH, van Luyn MJ. Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am J Pathol 2007; 170: 818-29."},{"key":"14","unstructured":"14. Kimura S, Egashira K, Chen L, <i>et al<\/i>. Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension. Hypertension 2009; 53: 877-83."},{"key":"15","unstructured":"15. Nakano K, Egashira K, Masuda S, <i>et al<\/i>. Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. JACC Cardiovasc Interv 2009; 2: 277-83."},{"key":"16","unstructured":"16. Akagi S, Nakamura K, Miura D, <i>et al<\/i>. Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension. Int Heart J 2015; 56: 354-9."},{"key":"17","unstructured":"17. Matoba T, Egashira K. Nanoparticle-mediated drug delivery system for cardiovascular disease. Int Heart J 2014; 55: 281-6. (Review)"},{"key":"18","unstructured":"18. Chen L, Nakano K, Kimura S, <i>et al<\/i>. Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension. Hypertension 2011; 57: 343-50."},{"key":"19","unstructured":"19. Tsukie N, Nakano K, Matoba T, <i>et al<\/i>. Pitavastatin-incorporated nanoparticle-eluting stents attenuate in-stent stenosis without delayed endothelial healing effects in a porcine coronary artery model. J Atheroscler Thromb 2013; 20: 32-45."},{"key":"20","unstructured":"20. Nagaoka K, Matoba T, Mao Y, <i>et al<\/i>. A new therapeutic modality for acute myocardial infarction: nanoparticle-mediated delivery of pitavastatin induces cardioprotection from ischemia-reperfusion injury via activation of PI3K\/Akt pathway and anti-inflammation in a rat model. PLoS One 2015; 10: e0132451."},{"key":"21","unstructured":"21. Katsuki S, Matoba T, Nakashiro S, <i>et al<\/i>. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization\/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation 2014; 129: 896-906."},{"key":"22","unstructured":"22. Nakashiro S, Matoba T, Umezu R, <i>et al<\/i>. Pioglitazone-incorporated nanoparticles prevent plaque destabilization and rupture by regulating monocyte\/macrophage differentiation in apoE-\/- mice. Arterioscler Thromb Vasc Biol 2016; 36: 491-500."},{"key":"23","unstructured":"23. Murakami H, Kobayashi M, Takeuchi H, Kawashima Y. Preparation of poly (DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method. Int J Pharm 1999; 187: 143-52."},{"key":"24","unstructured":"24. Hayashidani S, Tsutsui H, Shiomi T, <i>et al<\/i>. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2002; 105: 868-73."},{"key":"25","unstructured":"25. Ikeda G, Matoba T, Nakano Y, <i>et al<\/i>. Nanoparticle-mediated targeting of cyclosporine A enhances cardioprotection against ischemia-reperfusion injury through inhibition of mitochondrial permeability transition pore opening. Sci Rep 2016; 6: 20467."},{"key":"26","unstructured":"26. Tang XL, Rokosh G, Sanganalmath SK, <i>et al<\/i>. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation 2010; 121: 293-305."},{"key":"27","unstructured":"27. Koga J, Egashira K, Matoba T, <i>et al<\/i>. Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis. Hypertens Res 2008; 31: 1791-800."},{"key":"28","unstructured":"28. Ishibashi M, Hiasa K, Zhao Q, <i>et al<\/i>. Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling. Circ Res 2004; 94: 1203-10."},{"key":"29","unstructured":"29. Kintscher U, Wakino S, Kim S, Fleck E, Hsueh WA, Law RE. Angiotensin II induces migration and Pyk2\/paxillin phosphorylation of human monocytes. Hypertension 2001; 37: 587-93."},{"key":"30","unstructured":"30. Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol 2014; 14: 392-404."},{"key":"31","unstructured":"31. Dutta P, Nahrendorf M. Monocytes in myocardial infarction. Arterioscler Thromb Vasc Biol 2015; 35: 1066-70. (Review)"},{"key":"32","unstructured":"32. Jia T, Pamer EG. Immunology. Dispensable but not irrelevant. Science 2009; 325: 549-50."},{"key":"33","unstructured":"33. Veillard NR, Braunersreuther V, Arnaud C, <i>et al<\/i>. 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