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Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy. Int J Clin Exp Pathol 2015; 8: 530-40."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Wang GK, Zhu JQ, Zhang JT, <i>et al<\/i>. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 2010; 31: 659-66.","DOI":"10.1093\/eurheartj\/ehq013"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ucar A, Gupta SK, Fiedler J, <i>et al<\/i>. The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun 2012; 3: 1078.","DOI":"10.1038\/ncomms2090"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Greco CM, Condorelli G. Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure. Nat Rev Cardiol 2015; 12: 488-97.","DOI":"10.1038\/nrcardio.2015.71"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. 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Am J Physiol Heart Circ Physiol 2010; 299: H175-83.","DOI":"10.1152\/ajpheart.01211.2009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Shimizu I, Minamino T. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol 2016; 97: 245-62.","DOI":"10.1016\/j.yjmcc.2016.06.001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kavazis AN. Pathological vs. physiological cardiac hypertrophy. J Physiol 2015; 593: 3767.","DOI":"10.1113\/JP271161"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Fernandes T, Hashimoto NY, Magalhaes FC, <i>et al<\/i>. Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension 2011; 58: 182-9.","DOI":"10.1161\/HYPERTENSIONAHA.110.168252"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. 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