{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:21:18Z","timestamp":1792462878410,"version":"4.5.0"},"reference-count":30,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2018,11,30]]},"DOI":"10.1536\/ihj.17-582","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T22:37:24Z","timestamp":1540420644000},"page":"1445-1453","source":"Crossref","is-referenced-by-count":8,"title":["Blood Pressure-Independent Effect of Olmesartan on Albuminuria in Mice Overexpressing Renin"],"prefix":"10.1536","volume":"59","author":[{"given":"Hiroaki","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuyo","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Tanno","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Yokono","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Stroke Medicine, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Osanai","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Hirosaki University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Okumura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Saiseikai Kumamoto Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"name":"Department of Hypertension and Stroke Medicine, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Tanno T, Tomita H, Narita I, <i>et al<\/i>. Olmesartan inhibits cardiac hypertrophy in mice overexpressing renin independently of blood pressure: its beneficial effects on ACE2\/Ang (1-7)\/Mas axis and NAPDH oxidase expression. J Cardiovasc Pharmacol 2016; 67: 503-9.","DOI":"10.1097\/FJC.0000000000000374"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Huby AC, Kavvadas P, Alfieri C, <i>et al<\/i>. The RenTg mice: a powerful tool to study renin-dependent chronic kidney disease. PLoS One 2012; 7: e52362.","DOI":"10.1371\/journal.pone.0052362"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Caron KM, James LR, Kim HS, <i>et al<\/i>. A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A 2002; 99: 8248-52.","DOI":"10.1073\/pnas.112222199"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Caron KM, James LR, Kim HS, <i>et al<\/i>. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc Natl Acad Sci U S A 2004; 101: 3106-11.","DOI":"10.1073\/pnas.0307333101"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Donoghue M, Hsieh F, Baronas E, <i>et al<\/i>. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000; 87: E1-9.","DOI":"10.1161\/01.RES.87.5.e1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol Heart Circ Physiol 2005; 289: H2281-90.","DOI":"10.1152\/ajpheart.00618.2005"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000; 275: 33238-43.","DOI":"10.1074\/jbc.M002615200"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Santos RA, Simoes e Silva AC, Maric C, <i>et al<\/i>. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A 2003; 100: 8258-63.","DOI":"10.1073\/pnas.1432869100"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Santos RA, Ferreira AJ, Verano-Braga T, Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin angiotensin system. J Endocrinol 2013; 216: R1-R17.","DOI":"10.1530\/JOE-12-0341"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Sampaio WO, Henrique de Castro CH, Santos RA, Schiffrin EL, Touyz RM. Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension 2007; 50: 1093-8.","DOI":"10.1161\/HYPERTENSIONAHA.106.084848"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension 2010; 55: 166-71.","DOI":"10.1161\/HYPERTENSIONAHA.109.141622"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Araujo M, Wilcox CS. Oxidative stress in hypertension: role of the kidney. Antioxid Redox Signal 2014; 20: 74-101.","DOI":"10.1089\/ars.2013.5259"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ono T, Sanai T, Miyahara Y, Noda R. Olmesartan is more effective than other angiotensin receptor antagonists in reducing proteinuria in patients with chronic kidney disease other than diabetic nephropathy. Curr Ther Res Clin Exp 2013; 74: 62-7.","DOI":"10.1016\/j.curtheres.2013.02.002"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Haller H, Ito S, Izzo JL, <i>et al<\/i>. Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes. N Engl J Med 2011; 364: 907-17.","DOI":"10.1056\/NEJMoa1007994"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Shiga Y, Miura SI, Motozato K, <i>et al<\/i>. Comparison of efficacy and safety of azilsartan and olmesartan in patients with essential hypertension. Int Heart J 2017; 58: 416-21.","DOI":"10.1536\/ihj.16-285"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol 2006; 17: 3067-75.","DOI":"10.1681\/ASN.2006050423"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int 2008; 74: 1610-6.","DOI":"10.1038\/ki.2008.497"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Van Vliet BN, Chafe LL, Montani JP. Characteristics of 24 h telemetered blood pressure in eNOS-knockout and C57BL\/6J control mice. J Physiol 2003; 549: 313-25.","DOI":"10.1113\/jphysiol.2003.041897"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lempi\u00e4inen J, Finckenberg P, Levijoki J, Mervaala E. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Br J Pharmacol 2012; 166: 1905-15.","DOI":"10.1111\/j.1476-5381.2012.01895.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ogawa S, Takeuchi K, Mori T, Nako K, Tsubono Y, Ito S. Effects of monotherapy of temocapril or candesartan with dose increments or combination therapy with both drugs on the suppression of diabetic nephropathy. Hypertens Res 2007; 30: 325-34.","DOI":"10.1291\/hypres.30.325"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Koka V, Huang XR, Chung ACK, Wang W, Truong LD, Lan HY. Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), But down-regulates ACE2 via the AT1-ERK\/p38 MAP kinase pathway. Am J Pathol 2008; 172: 1174-83.","DOI":"10.2353\/ajpath.2008.070762"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Soler MJ, Wysocki J, Batlle D. ACE2 alterations in kidney disease. Nephrol Dial Transplant 2013; 28: 2687-97.","DOI":"10.1093\/ndt\/gft320"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Oudit GY, Herzenberg AM, Kassiri Z, <i>et al<\/i>. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol 2006; 168: 1808-20.","DOI":"10.2353\/ajpath.2006.051091"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Patel VB, Clarke N, Wang Z, <i>et al<\/i>. Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE\/ADAM-17: a positive feedback mechanism in the RAS. J Mol Cell Cardiol 2014; 66: 167-76.","DOI":"10.1016\/j.yjmcc.2013.11.017"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Moon JY, Tanimoto M, Gohda T, <i>et al<\/i>. Attenuating effect of angiotensin-(1-7) on angiotensin II-mediated NAD (P) H oxidase activation in type 2 diabetic nephropathy of KK-A (y)\/Ta mice. Am J Physiol Renal Physiol 2011; 300: F1271-82.","DOI":"10.1152\/ajprenal.00065.2010"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wysocki J, Ortiz-Melo DI, Mattocks NK, <i>et al<\/i>. ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiol Rep 2014; 2: e00264.","DOI":"10.1002\/phy2.264"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Hughson MD, Puelles VG, Hoy WE, Douglas-Denton RN, Mott SA, Bertram JF. Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. Nephrol Dial Transplant 2014; 29: 1399-409.","DOI":"10.1093\/ndt\/gft480"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hartono SP, Knudsen BE, Lerman LO, Textor SC, Grande JP. Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db\/db mice. BMC Nephrol 2014; 15: 58.","DOI":"10.1186\/1471-2369-15-58"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Ferrario C. Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil. Vasc Health Risk Manag 2009; 5: 301-14.","DOI":"10.2147\/VHRM.S3141"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Takayama T, Yoda S, Yajima Y, <i>et al<\/i>. Improvements in augmentation index and urinary albumin excretion with Benidipine in hypertensive patients with chronic kidney disease. Int Heart J 2016; 57: 53-60.","DOI":"10.1536\/ihj.15-208"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/59\/6\/59_17-582\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T05:02:53Z","timestamp":1543640573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/59\/6\/59_17-582\/_article"}},"subtitle":["Its Beneficial Role in the ACE2\/Ang (1-7)\/Mas Axis and NADPH Oxidase Expression"],"short-title":[],"issued":{"date-parts":[[2018,11,30]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.17-582","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,30]]}}}