{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:14:09Z","timestamp":1769123649647,"version":"3.49.0"},"reference-count":39,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1536\/ihj.17-610","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T22:46:46Z","timestamp":1535496406000},"page":"1034-1040","source":"Crossref","is-referenced-by-count":24,"title":["Endothelial Dysfunction Is Associated with Cognitive Impairment of Elderly Cardiovascular Disease Patients"],"prefix":"10.1536","volume":"59","author":[{"given":"Kazuhiro","family":"Fujiyoshi","sequence":"first","affiliation":[{"name":"Kitasato University Graduate School of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Yamaoka-Tojo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University School of Allied Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kutsuna","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, Kitasato University East Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, Kitasato University East Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Kitasato University Graduate School of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyoshi","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Kitasato University Graduate School of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Kitasato University Graduate School of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Namba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shimohama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Tojo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Ako","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kitasato University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.hrthm.2012.07.026","volume":"9","year":"2012","unstructured":"1. Santangeli P, Di Biase L, Bai R, <i>et al<\/i>. Atrial fibrillation and the risk of incident dementia: A meta-analysis. Heart Rhythm 2012; 9: 1761-8.","journal-title":"Heart Rhythm","ISSN":"https:\/\/id.crossref.org\/issn\/1547-5271","issn-type":"print"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Jefferson AL, Himali JJ, Au R, <i>et al<\/i>. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). Am J Cardiol 2011; 108: 1346-51.","DOI":"10.1016\/j.amjcard.2011.06.056"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Sauv\u00e9 MJ, Lewis WR, Blankenbiller M, Rickabaugh B, Pressler SJ. Cognitive impairments in chronic heart failure: A case controlled study. J Card Fail 2009; 15: 1-10.","DOI":"10.1016\/j.cardfail.2008.08.007"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Staessen JA, Richart T, Birkenh\u00e4ger WH. Less atherosclerosis and lower blood pressure for a meaningful life perspective with more brain. Hypertension 2007; 49: 389-400.","DOI":"10.1161\/01.HYP.0000258151.00728.d8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Reitz C, Tang MX, Luchsinger J, Mayeux R. Relation of plasma lipids to Alzheimer disease and vascular dementia. Arch Neurol 2004; 61: 705-14.","DOI":"10.1001\/archneur.61.5.705"},{"key":"6","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2009.460","volume":"301","year":"2009","unstructured":"6. Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009; 301: 1565-72.","journal-title":"JAMA The Journal of the American Medical Association","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. O&apos;Donnell M, Teo K, Gao P, <i>et al<\/i>. Cognitive impairment and risk of cardiovascular events and mortality. Eur Heart J 2012; 33: 1777-86.","DOI":"10.1093\/eurheartj\/ehs053"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Vendemiale G, Romano AD, Dagostino M, de Matthaeis A, Serviddio G. Endothelial dysfunction associated with mild cognitive impairment in elderly population. Aging Clin Exp Res 2013; 25: 247-55.","DOI":"10.1007\/s40520-013-0043-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Reijmer YD, van den Berg E, Dekker JM, <i>et al<\/i>. The metabolic syndrome, atherosclerosis and cognitive functioning in a non-demented population: The Hoorn Study. Atherosclerosis 2011; 219: 839-45.","DOI":"10.1016\/j.atherosclerosis.2011.08.032"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Higashi Y. Assessment of endothelial function. History, methodological aspects, and clinical perspectives. Int Heart J 2015; 56: 125-34.","DOI":"10.1536\/ihj.14-385"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Matsuzawa Y, Sugiyama S, Sugamura K, <i>et al<\/i>. Digital assessment of endothelial function and ischemic heart disease in women. J Am Coll Cardiol 2010; 55: 1688-96.","DOI":"10.1016\/j.jacc.2009.10.073"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Brevetti G, Silvestro A, Schiano V, Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: Additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 2003; 108: 2093-8.","DOI":"10.1161\/01.CIR.0000095273.92468.D9"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Suzuki H, Matsuzawa Y, Konishi M, <i>et al<\/i>. Utility of noninvasive endothelial function test for prediction of deep vein thrombosis after total hip or knee arthroplasty. Circ J 2014; 78: 1723-32.","DOI":"10.1253\/circj.CJ-13-1325"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kuvin JT, Patel AR, Sliney KA, <i>et al<\/i>. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 2003; 146: 168-74.","DOI":"10.1016\/S0002-8703(03)00094-2"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hamburg NM, Keyes MJ, Larson MG, <i>et al<\/i>. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study Naomi. Circulation 2009; 117: 2467-74.","DOI":"10.1161\/CIRCULATIONAHA.107.748574"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Matsubara J, Sugiyama S, Akiyama E, <i>et al<\/i>. Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes. Circ J 2013; 77: 1337-44.","DOI":"10.1253\/circj.CJ-12-1168"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Liu J, Wang J, Jin Y, Roethig HJ, Unverdorben M. Variability of peripheral arterial tonometry in the measurement of endothelial function in healthy men. Clin Cardiol 2009; 32: 700-4.","DOI":"10.1002\/clc.20668"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Folstein MF, Folstein SE, McHugh PR.  &quot;Mini-mental state&quot;: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Gauthier S, Reisberg B, Zaudig M, <i>et al<\/i>. Mild cognitive impairment. Lancet 2006; 367: 1262-70.","DOI":"10.1016\/S0140-6736(06)68542-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Abete P, Della-Della-Morte D, Gargiulo G, <i>et al<\/i>. Cognitive impairment and cardiovascular diseases in the elderly. A heart-brain continuum hypothesis. Ageing Res Rev 2014; 18: 41-52.","DOI":"10.1016\/j.arr.2014.07.003"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Ngandu T, Lehtisalo J, Solomon A, <i>et al<\/i>. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial. Lancet 2015; 385: 2255-63.","DOI":"10.1016\/S0140-6736(15)60461-5"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Petersen RC, Morris JC. Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol  2005; 62: 1160-3; discussion 1167.","DOI":"10.1001\/archneur.62.7.1160"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Su Y, Liu XM, Sun YM, <i>et al<\/i>. The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes. Int J Clin Pract 2008; 62: 877-82.","DOI":"10.1111\/j.1742-1241.2008.01776.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Boegehold MA. The effect of high salt intake on endothelial function: reduced vascular nitric oxide in the absence of hypertension. J Vasc Res 2013; 50: 458-67.","DOI":"10.1159\/000355270"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Conraads VM, Van Craenenbroeck EM, De Maeyer C, Van Berendoncks AM, Beckers PJ, Vrints CJ. Unraveling new mechanisms of exercise intolerance in chronic heart failure. Role of exercise training. Heart Fail Rev 2013; 18: 65-77.","DOI":"10.1007\/s10741-012-9324-0"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Chambliss KL, Yuhanna IS, Mineo C, <i>et al<\/i>. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res 2000; 87: E44-52.","DOI":"10.1161\/01.RES.87.11.e44"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Pizzi C, Manzoli L, Mancini S, Costa GM. Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function. Eur Heart J 2008; 29: 1110-7.","DOI":"10.1093\/eurheartj\/ehn137"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ruan Y, Wei W, Yan J, <i>et al<\/i>. Time rate of blood pressure variation is associated with endothelial function in patients with metabolic syndrome. Int Heart J 2016; 57: 226-33.","DOI":"10.1536\/ihj.15-322"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Verma S, Wang CH, Li SH, <i>et al<\/i>. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 2002; 106: 913-9.","DOI":"10.1161\/01.CIR.0000029802.88087.5E"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Bai Y, Wang X, Shen L, <i>et al<\/i>. Mechanical stress regulates endothelial progenitor cell angiogenesis through VEGF receptor endocytosis. Int Heart J 2016; 57: 356-62.","DOI":"10.1536\/ihj.15-387"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Festa JR, Jia X, Cheung K, <i>et al<\/i>. Association of low ejection fraction with impaired verbal memory in older patients with heart failure. Arch Neurol 2011; 68: 1021-6.","DOI":"10.1001\/archneurol.2011.163"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Zuccal\u00e0 G,  Onder G, Pedone C, <i>et al<\/i>. Hypotension and cognitive impairment: selective association in patients with heart failure. Neurology 2001; 57: 1986-92.","DOI":"10.1212\/WNL.57.11.1986"},{"key":"33","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1161\/01.CIR.103.13.1746","volume":"103","year":"2001","unstructured":"33. Gibbs CR, Blann AD, Watson RD, Lip GY. Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm: Effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy. Circulation 2001; 103: 1746-51.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Tomiyama H, Yoshida M, Higashi Y, <i>et al<\/i>. Autonomic nervous activation triggered during induction of reactive hyperemia exerts a greater influence on the measured reactive hyperemia index by peripheral arterial tonometry than on flow-mediated vasodilatation of the brachial artery in patients with hypertension. Hypertens Res 2014; 37: 914-8.","DOI":"10.1038\/hr.2014.103"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Bonetti PO, Barsness GW, Keelan PC, <i>et al<\/i>. Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease. J Am Coll Cardiol 2003; 41: 1761-8.","DOI":"10.1016\/S0735-1097(03)00329-2"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36. de la Torre JC. Alzheimer disease as a vascular disorder: Nosological evidence. Stroke 2002; 33: 1152-62.","DOI":"10.1161\/01.STR.0000014421.15948.67"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Rom\u00e1n GC. Vascular dementia may be the most common form of dementia in the elderly. J Neurol Sci 2002; 203-204: 7-10.","DOI":"10.1016\/S0022-510X(02)00252-6"},{"key":"38","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","volume":"42","year":"2011","unstructured":"38. Gorelick PB, Scuteri A, Black SE, <i>et al<\/i>. Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 2011; 42: 2672-713.","journal-title":"Stroke","ISSN":"https:\/\/id.crossref.org\/issn\/0039-2499","issn-type":"print"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer&apos;s disease prevalence. Lancet Neurol 2011; 10: 819-28.","DOI":"10.1016\/S1474-4422(11)70072-2"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/59\/5\/59_17-610\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T05:07:55Z","timestamp":1538197675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/59\/5\/59_17-610\/_article"}},"subtitle":["A Reactive Hyperemia-Peripheral Arterial Tonometry Study"],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.17-610","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}