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Matsubara J, Sugiyama S, Akiyama E, <i>et al<\/i>. Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes. Circ J 2013; 77: 1337-44.","DOI":"10.1253\/circj.CJ-12-1168"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Nystr\u00f6m T, Gutniak MK, Zhang Q, <i>et al<\/i>. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004; 287: E1209-15.","DOI":"10.1152\/ajpendo.00237.2004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Sato A, Suzuki S, Watanabe S, <i>et al<\/i>. DPP4 inhibition ameliorates cardiac function by blocking the cleavage of HMGB1 in diabetic mice after myocardial infarction. Int Heart J 2017; 58: 778-86.","DOI":"10.1536\/ihj.16-547"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. 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Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: relation to pathogenesis of catecholamine cardiomyopathy. Am Heart J 1981; 102: 210-21.","DOI":"10.1016\/S0002-8703(81)80012-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Todd GL, Cullan GE, Cullan GM. Isoproterenol-induced myocardial necrosis and membrane permeability alterations in the isolated perfused rabbit heart. Exp Mol Pathol 1980; 33: 43-54.","DOI":"10.1016\/0014-4800(80)90006-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Lee TM, Chen WT, Yang CC, Lin SZ, Chang NC. Sitagliptin attenuates sympathetic innervation via modulating reactive oxygen species and interstitial adenosine in infarcted rat hearts. J Cell Mol Med 2015; 19: 418-29.","DOI":"10.1111\/jcmm.12465"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lee TM, Lai PY, Chang NC. Effect of N-acetylcysteine on sympathetic hyperinnervation in post-infarcted rat hearts. 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Moringa oleifera leaf extract prevents isoproterenol-induced myocardial damage in rats: evidence for an antioxidant, antiperoxidative, and cardioprotective intervention. J Med Food 2009; 12: 47-55.","DOI":"10.1089\/jmf.2007.0563"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985; 17: 291-306.","DOI":"10.1016\/S0022-2828(85)80130-9"},{"key":"18","unstructured":"18. Oikawa J, Niwano S, Niwano H, <i>et al<\/i>. Anti-oxidant compound suppresses the construction of arrhythmogenic substrate in the isoproterenol induced acute myocardial injury. The 80th Annual Scientific Meeting of the Japanese Circulation Society abstract 2016; PE-708."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Saito J, Niwano S, Niwano H, <i>et al<\/i>. Electrical remodeling of the ventricular myocardium in myocarditis: studies of rat experimental autoimmune myocarditis. 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J Clin Invest 1996; 97: 656-63.","DOI":"10.1172\/JCI118462"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Liu T, Shi SB, Qin M, Huang CX. Effects of dantrolene treatment on ventricular electrophysiology and arrhythmogenesis in rats with chronic \u03b2-adrenergic receptor activation. J Cardiovasc Pharmacol Ther 2015; 20: 414-27.","DOI":"10.1177\/1074248414568194"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Zipes DP, Wellens HJ. Sudden cardiac death. Circulation 1998; 98: 2334-51.","DOI":"10.1161\/01.CIR.98.21.2334"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Hwang KK, Eom SY, Lee SY, <i>et al<\/i>. Atrial fibrillation on admission is related with higher mortality in ST-segment elevation myocardial infarction patients. 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