{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:41:51Z","timestamp":1788892911486,"version":"build-2803163510"},"reference-count":30,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2021,9,29]]},"DOI":"10.1536\/ihj.21-032","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T22:30:03Z","timestamp":1632954603000},"page":"1135-1144","source":"Crossref","is-referenced-by-count":8,"title":["Urotensin II Induces Cardiac Fibrosis through the TGF-\u03b2\/Smad Signaling Pathway during the Development of Cardiac Hypertrophy"],"prefix":"10.1536","volume":"62","author":[{"given":"Yanyan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Dominguez-Rodriguez A, Abreu-Gonzalez P. Hypertrophic cardiomyopathy. Lancet 2013; 381: 1456-7.","DOI":"10.1016\/S0140-6736(13)60921-6"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Hershberger RE, Cowan J, Morales A, Siegfried JD. Progress with genetic cardiomyopathies: screening, counseling, and testing in dilated, hypertrophic, and arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Circ Heart Fail 2009; 2: 253-61.","DOI":"10.1161\/CIRCHEARTFAILURE.108.817346"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Moreno V, Hern\u00e1ndez-Romero D, Vilchez JA, <i>et al<\/i>. Serum levels of high-sensitivity troponin T: a novel marker for cardiac remodeling in hypertrophic cardiomyopathy. J Card Fail 2010; 16: 950-6.","DOI":"10.1016\/j.cardfail.2010.07.245"},{"key":"4","first-page":"1308","volume":"287","year":"2002","unstructured":"4. Maron BJ. Hypertrophic cardiomyopathy: a systematic review. JAMA 2002; 287: 1308-20.","journal-title":"JAMA The Journal of the American Medical Association","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Pearson D, Shively JE, Clark BR, <i>et al<\/i>. Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes. Proc Natl Acad Sci USA 1980; 77: 5021-4.","DOI":"10.1073\/pnas.77.8.5021"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Ames RS, Sarau HM, Chambers JK, <i>et al<\/i>. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 1999; 401: 282-6.","DOI":"10.1038\/45809"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Coulouarn Y, J\u00e9gou S, Tostivint H, Vaudry H, Lihrmann I. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett 1999; 457: 28-32.","DOI":"10.1016\/S0014-5793(99)01003-0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bottrill FE, Douglas SA, Hiley CR, White R. Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries. Br J Pharmacol 2000; 130: 1865-70.","DOI":"10.1038\/sj.bjp.0703513"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Pereira-Castro J, Br\u00e1s-Silva C, Fontes-Sousa AP. Novel insights into the role of urotensin II in cardiovascular disease. Drug Discov Today 2019; 24: 2170-80.","DOI":"10.1016\/j.drudis.2019.08.005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Stirrat A, Gallagher M, Douglas SA, <i>et al<\/i>. Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries. Am J Physiol Heart Circ Physiol 2001; 280: H925-8.","DOI":"10.1152\/ajpheart.2001.280.2.H925"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Totsune K, Takahashi K, Arihara Z, Sone M, Ito S, Murakami O. Increased plasma urotensin II levels in patients with diabetes mellitus. Clin Sci 2003; 104: 1-5.","DOI":"10.1042\/cs1040001"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Russell FD. Emerging roles of urotensin-II in cardiovascular disease. Pharmacol Ther 2004; 103: 223-43.","DOI":"10.1016\/j.pharmthera.2004.07.004"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Nakayama T, Hirose T, Totsune K, <i>et al<\/i>. Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure. Peptides 2008; 29: 801-8.","DOI":"10.1016\/j.peptides.2007.12.018"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Hirose T, Takahashi K, Mori N, <i>et al<\/i>. Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1. Peptides 2009; 30: 1124-9.","DOI":"10.1016\/j.peptides.2009.02.009"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Mori N, Hirose T, Nakayama T, <i>et al<\/i>. Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure. Peptides 2009; 30: 400-8.","DOI":"10.1016\/j.peptides.2008.09.021"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Katano Y, Ishihata A, Aita T, Ogaki T, Horie T. Vasodilator effect of urotensin II, one of the most potent vasoconstricting factors, on rat coronary arteries. Eur J Pharmacol 2000; 402: R5-7.","DOI":"10.1016\/S0014-2999(00)00506-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Jumaah S, \u00c7elekli A, Sucu M. The role of human urotensin-II in patients with hypertrophic cardiomyopathy. J Immunoassay Immunochem 2018; 39: 150-62.","DOI":"10.1080\/15321819.2017.1344130"},{"key":"18","unstructured":"18. Zhang X, Ye Y, Yang C, <i>et al<\/i>. Clinical significance of increased urotensin II levels in acute myocardial infarction. Discov Med 2018; 26: 7-20."},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Gong H, Ma H, Liu M, <i>et al<\/i>. Urotensin II inhibits the proliferation but not the differentiation of cardiac side population cells. Peptides 2011; 32: 1035-41.","DOI":"10.1016\/j.peptides.2011.01.024"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Chen Z, Xu J, Ye Y, <i>et al<\/i>. Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling. J Cell Mol Med 2014; 18: 852-62.","DOI":"10.1111\/jcmm.12230"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zhang YG, Li YG, Liu BG, <i>et al<\/i>. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. Acta Pharmacol Sin 2007; 28: 36-43.","DOI":"10.1111\/j.1745-7254.2007.00485.x"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Zou Y, Liang Y, Gong H, <i>et al<\/i>. Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy. Hypertension 2011; 58: 1099-110.","DOI":"10.1161\/HYPERTENSIONAHA.111.173500"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Zou Y, Komuro I, Yamazaki T, <i>et al<\/i>. Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. Circ Res 1998; 82: 337-45.","DOI":"10.1161\/01.RES.82.3.337"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Morine KJ, Qiao X, York S, <i>et al<\/i>. Bone morphogenetic protein 9 reduces cardiac fibrosis and improves cardiac function in heart failure. Circulation 2018; 138: 513-26.","DOI":"10.1161\/CIRCULATIONAHA.117.031635"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Dobaczewski M, Chen W, Frangogiannis NG. Transforming growth factor (TGF) -beta signaling in cardiac remodeling. J Mol Cell Cardiol 2011; 51: 600-6.","DOI":"10.1016\/j.yjmcc.2010.10.033"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Yue Y, Meng K, Pu Y, Zhang X. Transforming growth factor beta (TGF-beta) mediates cardiac fibrosis and induces diabetic cardiomyopathy. Diab Res Clin Pract 2017; 133: 124-30.","DOI":"10.1016\/j.diabres.2017.08.018"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Sniegon I, Priess M, Heger J, Schulz R, Euler G. Endothelial mesenchymal transition in hypoxic microvascular endothelial cells and paracrine induction of cardiomyocyte apoptosis are mediated via TGFbeta (1) \/SMAD signaling. Int J Mol Sci 2017; 18: 2290.","DOI":"10.3390\/ijms18112290"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Zou Y, Cai Y, Lu D, Zhou Y, Yao Q, Zhang S. MicroRNA-146a-5p attenuates liver fibrosis by suppressing profibrogenic effects of TGF\u03b21 and lipopolysaccharide. Cell Signal 2017; 39: 1-8.","DOI":"10.1016\/j.cellsig.2017.07.016"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Dai HY, He T, Li XL, Xu WL, Ge ZM. Urotensin-2 promotes collagen synthesis via ERK1\/2-dependent and ERK1\/2-independent TGF-b1 in neonatal cardiac fibroblasts. Cell Biol Int 2011; 35: 93-8.","DOI":"10.1042\/CBI20090104"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Liu W, Han Q, Liu Q, Liang G, Wang J, Liu C. An investigation into the expression and mechanism of action of urotensin II in chronic pressure-overloaded rat hearts. Mol Med Rep 2015; 12: 6626-34.","DOI":"10.3892\/mmr.2015.4244"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/62\/5\/62_21-032\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T06:38:06Z","timestamp":1633156686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/62\/5\/62_21-032\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.21-032","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]},"article-number":"21-032"}}