{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:09:13Z","timestamp":1788480553565,"version":"build-2803163510"},"reference-count":30,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2022,5,30]]},"DOI":"10.1536\/ihj.21-332","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T22:10:18Z","timestamp":1653948618000},"page":"602-611","source":"Crossref","is-referenced-by-count":7,"title":["Downregulation of lncRNA MALAT1 Inhibits Angiotensin II-induced Hypertrophic Effects of Cardiomyocytes by Regulating SIRT4 via miR-93-5p"],"prefix":"10.1536","volume":"63","author":[{"given":"Huanchun","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Cardiology, Dalian Second People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dalian Second People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dalian Second People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dalian Second People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Lyon RC, Zanella F, Omens JH, Sheikh F. Mechanotransduction in cardiac hypertrophy and failure. Circ Res 2015; 116: 1462-76.","DOI":"10.1161\/CIRCRESAHA.116.304937"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Shao M, Chen G, Lv F, <i>et al<\/i>. LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII. Oncotarget 2017; 8: 47565-73.","DOI":"10.18632\/oncotarget.17735"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Schirone L, Forte M, Palmerio S, <i>et al<\/i>. A review of the molecular mechanisms underlying the development and progression of cardiac remodeling. Oxid Med Cell Longev 2017; 2017: 3920195.","DOI":"10.1155\/2017\/3920195"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther 2010; 128: 191-227.","DOI":"10.1016\/j.pharmthera.2010.04.005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Diwan A, Dorn GW 2nd. Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets. Physiology (Bethesda) 2007; 22: 56-64.","DOI":"10.1152\/physiol.00033.2006"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Da Sacco L, Baldassarre A, Masotti A. Bioinformatics tools and novel challenges in long non-coding RNAs (lncRNAs) functional analysis. Int J Mol Sci 2012; 13: 97-114.","DOI":"10.3390\/ijms13010097"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Lai Y, He S, Ma L, <i>et al<\/i>. HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy. Mol Cell Biochem 2017; 432: 179-87.","DOI":"10.1007\/s11010-017-3008-y"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Wang K, Liu F, Zhou LY, <i>et al<\/i>. The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489. Circ Res 2014; 114: 1377-88.","DOI":"10.1161\/CIRCRESAHA.114.302476"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Liu L, An X, Li Z, <i>et al<\/i>. The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy. Cardiovasc Res 2016; 111: 56-65.","DOI":"10.1093\/cvr\/cvw078"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Gardner DG. Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab 2003; 14: 411-6.","DOI":"10.1016\/S1043-2760(03)00113-9"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Zhang J, Liang Y, Huang X, <i>et al<\/i>. STAT3-induced upregulation of lncRNA MEG3 regulates the growth of cardiac hypertrophy through miR-361-5p\/HDAC9 axis. Sci Rep 2019; 9: 460.","DOI":"10.1038\/s41598-018-36369-1"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Xiang Y, Zhang Y, Tang Y, Li Q. MALAT1 modulates TGF-beta1-Induced endothelial-to-mesenchymal transition through downregulation of miR-145. Cell Physiol Biochem 2017; 42: 357-72.","DOI":"10.1159\/000477479"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Huang S, Zhang L, Song J, <i>et al<\/i>. Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model. J Cell Physiol 2019; 234: 2997-3006.","DOI":"10.1002\/jcp.27117"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kishore A, Borucka J, Petrkova J, Petrek M. Novel insights into miRNA in lung and heart inflammatory diseases. Mediators Inflamm 2014; 2014: 259131.","DOI":"10.1155\/2014\/259131"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Li R, Jin Y, Li Q, Sun X, Zhu H, Cui H. MiR-93-5p targeting PTEN regulates the NMDA-induced autophagy of retinal ganglion cells via AKT\/mTOR pathway in glaucoma. Biomed Pharmacother 2018; 100: 1-7.","DOI":"10.1016\/j.biopha.2018.01.044"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. O&apos;Sullivan JF, Neylon A, Fahy EF, Yang P, McGorrian C, Blake GJ. MiR-93-5p is a novel predictor of coronary in-stent restenosis. Heart Asia 2019; 11: e011134.","DOI":"10.1136\/heartasia-2018-011134"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Li JP, Xiang Y, Fan LJ, Yao A, Li H, Liao XH. Long noncoding RNA H19 competitively binds miR-93-5p to regulate STAT3 expression in breast cancer. J Cell Biochem 2019; 120: 3137-48.","DOI":"10.1002\/jcb.27578"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Wo Y, Guo J, Li P, Yang H, Wo J. Long non-coding RNA CHRF facilitates cardiac hypertrophy through regulating Akt3 via miR-93. Cardiovasc Pathol 2018; 35: 29-36.","DOI":"10.1016\/j.carpath.2018.04.003"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Betsinger CN, Cristea IM. Mitochondrial function, metabolic regulation, and human disease viewed through the prism of sirtuin 4 (SIRT4) functions. J Proteome Res 2019; 18: 1929-38.","DOI":"10.1021\/acs.jproteome.9b00086"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Luo YX, Tang X, An XZ, <i>et al<\/i>. SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J 2017; 38: 1389-98.","DOI":"10.1093\/eurheartj\/ehw138"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Li C, Li X, Gao X, <i>et al<\/i>. MicroRNA-328 as a regulator of cardiac hypertrophy. Int J Cardiol 2014; 173: 268-76.","DOI":"10.1016\/j.ijcard.2014.02.035"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Yamamura S, Imai-Sumida M, Tanaka Y, Dahiya R. Interaction and cross-talk between non-coding RNAs. Cell Mol Life Sci 2018; 75: 467-84.","DOI":"10.1007\/s00018-017-2626-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Treiber T, Treiber N, Meister G. Regulation of microRNA biogenesis and function. Thromb Haemost 2012; 107: 605-10.","DOI":"10.1160\/TH11-12-0836"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Tao L, Yang L, Huang X, Hua F, Yang X. Reconstruction and analysis of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in dilated cardiomyopathy. Front Genet 2019; 10: 1149.","DOI":"10.3389\/fgene.2019.01149"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. G\u00f3mez J, Lorca R, Reguero JR, <i>et al<\/i>. Genetic variation at the long noncoding RNA H19 gene is associated with the risk of hypertrophic cardiomyopathy. Epigenomics 2018; 10: 865-73.","DOI":"10.2217\/epi-2017-0175"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Jing L, Li S, Wang J, Zhang G. Long non-coding RNA small nucleolar RNA host gene 7 facilitates cardiac hypertrophy via stabilization of SDA1 domain containing 1 mRNA. J Cell Biochem 2019; 120: 15089-97.","DOI":"10.1002\/jcb.28770"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Zhang M, Jiang Y, Guo X, <i>et al<\/i>. Long non-coding RNA cardiac hypertrophy-associated regulator governs cardiac hypertrophy via regulating miR-20b and the downstream PTEN\/AKT pathway. J Cell Mol Med 2019; 23: 7685-98.","DOI":"10.1111\/jcmm.14641"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Puthanveetil P, Gutschner T, Lorenzen J. MALAT1: a therapeutic candidate for a broad spectrum of vascular and cardiorenal complications. Hypertens Res 2020; 43: 372-9.","DOI":"10.1038\/s41440-019-0378-4"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Liu J, Jiang M, Deng S, <i>et al<\/i>. miR-93-5p-Containing exosomes treatment attenuates acute myocardial infarction-induced myocardial damage. Mol Ther Nucleic Acids 2018; 11: 103-15.","DOI":"10.1016\/j.omtn.2018.01.010"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Xiao Y, Zhang X, Fan S, Cui G, Shen Z. MicroRNA-497 inhibits cardiac hypertrophy by targeting Sirt4. PLoS One 2016; 11: e0168078.","DOI":"10.1371\/journal.pone.0168078"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/63\/3\/63_21-332\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T04:20:40Z","timestamp":1654316440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/63\/3\/63_21-332\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,30]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.21-332","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,30]]},"article-number":"21-332"}}