{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:21:14Z","timestamp":1789759274905,"version":"4.0.1"},"reference-count":31,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2022,9,30]]},"DOI":"10.1536\/ihj.21-404","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T22:11:11Z","timestamp":1663107071000},"page":"893-903","source":"Crossref","is-referenced-by-count":13,"title":["Pioglitazone Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis Through Inhibiting NLRP3\/Caspase-1 Pathway &lt;i&gt;in vivo&lt;\/i&gt; and &lt;i&gt;in vitro&lt;\/i&gt;"],"prefix":"10.1536","volume":"63","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Hospital of Yulin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Hospital of Yulin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Hospital of Yulin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Hospital of Yulin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 2013; 123: 92-100.","DOI":"10.1172\/JCI62874"},{"key":"2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.85.2.779","volume":"85","year":"1992","unstructured":"2. Ovize M, Kloner RA, Hale SL, Przyklenk K. Coronary cyclic flow variations &quot;precondition&quot; ischemic myocardium. Circulation 1992; 85: 779-89.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Eltzschig HK, Eckle T. Ischemia and reperfusion--from mechanism to translation. Nat Med 2011; 17: 1391-401.","DOI":"10.1038\/nm.2507"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Konstantinidis K, Whelan RS, Kitsis RN. Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol 2012; 32: 1552-62.","DOI":"10.1161\/ATVBAHA.111.224915"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Shiomi T, Tsutsui H, Hayashidani S, <i>et al<\/i>. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2002; 106: 3126-32.","DOI":"10.1161\/01.CIR.0000039346.31538.2C"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Zhong W, Jin W, Xu S, <i>et al<\/i>. Pioglitazone induces cardiomyocyte apoptosis and inhibits cardiomyocyte hypertrophy via VEGFR-2 signaling pathway. Arq Bras Cardiol 2018; 111: 162-9.","DOI":"10.5935\/abc.20180108"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Li J, Lang MJ, Mao XB, Tian L, Feng YB. Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic\/reperfused heart of rat. Cardiovasc Drugs Ther 2008; 22: 283-91.","DOI":"10.1007\/s10557-008-6115-x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Fu Y, Wang Y, Du L, <i>et al<\/i>. Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation. Int J Mol Sci 2013; 14: 14105-18.","DOI":"10.3390\/ijms140714105"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140: 821-32.","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 2010; 22: 28-33.","DOI":"10.1016\/j.coi.2009.12.004"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Qin D, Wang X, Li Y, <i>et al<\/i>. MicroRNA-223-5p and -3p cooperatively suppress necroptosis in ischemic\/reperfused hearts. J Biol Chem 2016; 291: 20247-59.","DOI":"10.1074\/jbc.M116.732735"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Toldo S, Marchetti C, Mauro AG, <i>et al<\/i>. Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse. Int J Cardiol 2016; 209: 215-20.","DOI":"10.1016\/j.ijcard.2016.02.043"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Hasegawa M, Kawase K, Inohara N, <i>et al<\/i>. Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells. Oncogene 2007; 26: 1748-56.","DOI":"10.1038\/sj.onc.1209965"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wang B, Cao X, Lin J, Qian Q, Yu L. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Biomed Pharmacother 2019; 114: 108683.","DOI":"10.1016\/j.biopha.2019.108683"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Ding H, Han R, Chen X, <i>et al<\/i>. Clematichinenoside (AR) attenuates hypoxia\/reoxygenation-induced H9c2 cardiomyocyte apoptosis via a mitochondria-mediated signaling pathway. Molecules 2016; 21: 683.","DOI":"10.3390\/molecules21060683"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Boateng S, Sanborn T. Acute myocardial infarction. Disease-a-month: DM 2013; 59: 83-96.","DOI":"10.1016\/j.disamonth.2012.12.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hu X, Ma R, Lu J, <i>et al<\/i>. IL-23 Promotes myocardial I\/R injury by increasing the inflammatory responses and oxidative stress reactions. Cell Physiol Biochem 2016; 38: 2163-72.","DOI":"10.1159\/000445572"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Xu T, Li D, Jiang D. Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following ischemia\/reperfusion. Nutrients 2012; 4: 2008-19.","DOI":"10.3390\/nu4122008"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Massion PB, Feron O, Dessy C, Balligand JL. Nitric oxide and cardiac function: ten years after, and continuing. Circ Res 2003; 93: 388-98.","DOI":"10.1161\/01.RES.0000088351.58510.21"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Baines CP. How and when do myocytes die during ischemia and reperfusion: the late phase. J Cardiovasc Pharmacol Ther 2011; 16: 239-43.","DOI":"10.1177\/1074248411407769"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zhang B, Zhou M, Li C, <i>et al<\/i>. MicroRNA-92a inhibition attenuates hypoxia\/reoxygenation-induced myocardiocyte apoptosis by targeting Smad7. PLoS One 2014; 9: e100298.","DOI":"10.1371\/journal.pone.0100298"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chen Z, Chua CC, Ho YS, Hamdy RC, Chua BH. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I\/R injury in transgenic mice. Am J Physiol Heart Circ Physiol 2001; 280: H2313-20.","DOI":"10.1152\/ajpheart.2001.280.5.H2313"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Wang N, Minatoguchi S, Chen X, <i>et al<\/i>. Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia\/reperfusion rabbit heart. Br J Clin Pharmacol 2004; 142: 983-90.","DOI":"10.1038\/sj.bjp.0705863"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Walter DH, Haendeler J, Galle J, Zeiher AM, Dimmeler S. Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria. Circulation 1998; 98: 1153-7.","DOI":"10.1161\/01.CIR.98.12.1153"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Gottlieb RA. Cell death pathways in acute ischemia\/reperfusion injury. J Cardiovasc Pharmacol Ther 2011; 16: 233-8.","DOI":"10.1177\/1074248411409581"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Han J, Wang D, Ye L, <i>et al<\/i>. Rosmarinic acid protects against inflammation and cardiomyocyte apoptosis during myocardial ischemia\/reperfusion injury by activating peroxisome proliferator-activated receptor gamma. Front Pharmacol 2017; 8: 456.","DOI":"10.3389\/fphar.2017.00456"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Chen G, Song X, Lin D, Xu P. Isofraxidin alleviates myocardial infarction through NLRP3 inflammasome inhibition. Inflammation 2020; 43: 712-21.","DOI":"10.1007\/s10753-019-01158-z"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Xu Y, Yao J, Zou C, <i>et al<\/i>. Asiatic acid protects against hepatic ischemia\/reperfusion injury by inactivation of Kupffer cells via PPAR\u03b3\/NLRP3 inflammasome signaling pathway. Oncotarget 2017; 8: 86339-55.","DOI":"10.18632\/oncotarget.21151"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Luo H, Fan Z, Xiang D, <i>et al<\/i>. The protective effect of umbelliferone ameliorates myocardial injury following ischemia-reperfusion in the rat through suppression NLRP3 inflammasome and upregulating the PPAR-\u03b3. Mol Med Rep 2018; 17: 3404-10.","DOI":"10.3892\/mmr.2017.8208"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wang Q, Lin P, Li P, <i>et al<\/i>. Ghrelin protects the heart against ischemia\/reperfusion injury via inhibition of TLR4\/NLRP3 inflammasome pathway. Life Sci 2017; 186: 50-8.","DOI":"10.1016\/j.lfs.2017.08.004"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kim SH, Jun JH, Oh JE, Shin EJ, Oh YJ, Choi YS. Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats. PloS One 2018; 13: e0198307.","DOI":"10.1371\/journal.pone.0198307"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/63\/5\/63_21-404\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T04:12:44Z","timestamp":1664597564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/63\/5\/63_21-404\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.21-404","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"article-number":"21-404"}}