{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:38:59Z","timestamp":1791279539814,"version":"4.1.0"},"reference-count":49,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2022,5,30]]},"DOI":"10.1536\/ihj.21-511","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T22:10:22Z","timestamp":1653948622000},"page":"578-590","source":"Crossref","is-referenced-by-count":18,"title":["LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p\/TLR4\/NF-\u03baB Pathway"],"prefix":"10.1536","volume":"63","author":[{"given":"Haibo","family":"Du","sequence":"first","affiliation":[{"name":"Heart Disease Center, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shenzhen Samii Medical Center (The Fourth People's Hospital of Shenzhen)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yibin Second People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daqing Oil Field General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yibin Second People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Yousuf T, Nakhle A, Rawal H, Harrison D, Maini R, Irimpen A. Natural disasters and acute myocardial infarction. Prog Cardiovasc Dis 2020; 63: 510-7.","DOI":"10.1016\/j.pcad.2020.05.003"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-35.","DOI":"10.1056\/NEJMra071667"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet 2016; 17: 47-62.","DOI":"10.1038\/nrg.2015.10"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Zhu L, Zhao S, Zhao W. Potential regulatory role of lncRNA-miRNA-mRNA in coronary artery disease (CAD). Int Heart J 2021; 62: 1369-78.","DOI":"10.1536\/ihj.21-156"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ghafouri-Fard S, Shoorei H, Taheri M. Non-coding RNAs participate in the ischemia-reperfusion injury. Biomed Pharmacother 2020; 129: 110419.","DOI":"10.1016\/j.biopha.2020.110419"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Zhang R, Wang J, Liu B, <i>et al<\/i>. Differentially expressed lncRNAs, miRNAs and mRNAs with associated ceRNA networks in a mouse model of myocardial ischemia\/reperfusion injury. Mol Med Rep 2020; 22: 2487-95.","DOI":"10.3892\/mmr.2020.11300"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Zou L, Ma X, Lin S, Wu B, Chen Y, Peng C. Long noncoding RNA-MEG3 contributes to myocardial ischemia-reperfusion injury through suppression of miR-7-5p expression. Biosci Rep 2019; 39.","DOI":"10.1042\/BSR20190210"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Wang K, Liu F, Liu CY, <i>et al<\/i>. The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873. Cell Death Differ 2016; 23: 1394-405.","DOI":"10.1038\/cdd.2016.28"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zhang L, Yang C, Qiu B. LncRNA RP11-400K9.4 aggravates cardiomyocytes apoptosis after hypoxia\/reperfusion injury by targeting miR-423. Int Heart J 2021; 62: 1124-34.","DOI":"10.1536\/ihj.20-828"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Pei YH, Chen J, Wu X, <i>et al<\/i>. LncRNA PEAMIR inhibits apoptosis and inflammatory response in PM2.5 exposure aggravated myocardial ischemia\/reperfusion injury as a competing endogenous RNA of miR-29b-3p. Nanotoxicology 2020; 14: 638-53.","DOI":"10.1080\/17435390.2020.1731857"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hu X, Liu B, Wu P, Lang Y, Li T. LncRNA Oprm1 overexpression attenuates myocardial ischemia\/reperfusion injury by increasing endogenous hydrogen sulfide via Oprm1\/miR-30b-5p\/CSE axis. Life Sci 2020; 254: 117699.","DOI":"10.1016\/j.lfs.2020.117699"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Shuai Y, Ma Z, Lu J, Feng J. LncRNA SNHG15: A new budding star in human cancers. Cell Prolif 2020; 53: e12716.","DOI":"10.1111\/cpr.12716"},{"key":"13","unstructured":"13. Wen Y, Zhang X, Liu X, Huo Y, Gao Y, Yang Y. Suppression of lncRNA SNHG15 protects against cerebral ischemia-reperfusion injury by targeting miR-183-5p\/FOXO1 axis. Am J Transl Res 2020; 12: 6250-63."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Fan Y, Wei L, Zhang S, <i>et al<\/i>. LncRNA SNHG15 knockdown protects against OGD\/R-induced neuron injury by downregulating TP53INP1 expression via binding to miR-455-3p. Neurochem Res 2021; 46: 1019-30.","DOI":"10.1007\/s11064-020-03222-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Chen D, Zhang Z, Lu X, Yang X. Long non-coding RNA SNHG15 regulates cardiomyocyte apoptosis after hypoxia\/reperfusion injury via modulating miR-188-5p\/PTEN axis. Arch Physiol Biochem 2020; 1-8.","DOI":"10.1080\/13813455.2020.1819336"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Iwakawa HO, Tomari Y. The functions of microRNAs: mRNA decay and translational repression. Trends Cell Biol 2015; 25: 651-65.","DOI":"10.1016\/j.tcb.2015.07.011"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Fan ZX, Yang J. The role of microRNAs in regulating myocardial ischemia reperfusion injury. Saudi Med J 2015; 36: 787-93.","DOI":"10.15537\/smj.2015.7.11089"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Makhdoumi P, Roohbakhsh A, Karimi G. MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury. Biomed Pharmacother 2016; 84: 1635-44.","DOI":"10.1016\/j.biopha.2016.10.073"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Qin SQ, Zhang ZS, Wang XY, Shi JZ, Yang XB. MiR-24 protects cardiomyocytes against hypoxia\/reoxygenation-induced injury through regulating mitogen-activated protein kinase 14. Int Heart J 2020; 61: 806-14.","DOI":"10.1536\/ihj.19-496"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Zhang S, Zhang R, Wu F, Li X. MicroRNA-208a regulates H9c2 cells simulated ischemia-reperfusion myocardial injury via targeting CHD9 through notch\/NF-kappa B signal pathways. Int Heart J 2018; 59: 580-8.","DOI":"10.1536\/ihj.17-147"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wu F, Han B, Wu S, <i>et al<\/i>. Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p\/TIPARP. J Neurosci 2019; 39: 7369-93.","DOI":"10.1523\/JNEUROSCI.0299-19.2019"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Paraskevopoulou MD, Hatzigeorgiou AG. Analyzing MiRNA-LncRNA interactions. Methods Mol Biol 2016; 1402: 271-86.","DOI":"10.1007\/978-1-4939-3378-5_21"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Guo LL, Guo ML, Yao J, Weng YQ, Zhang XZ. MicroRNA-421 improves ischemia\/reperfusion injury via regulation toll-like receptor 4 pathway. J Int Med Res 2020; 48: 300060519871863.","DOI":"10.1177\/0300060519871863"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Hossain M, Banik NL, Ray SK. Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells. Neurochem Int 2012; 61: 1102-13.","DOI":"10.1016\/j.neuint.2012.08.002"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Paraskevopoulou MD, Vlachos IS, Karagkouni D, <i>et al<\/i>. Diana-LncBase v2: indexing microRNA targets on non-coding transcripts. Nucleic Acids Res 2016; 44: D231-8.","DOI":"10.1093\/nar\/gkv1270"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Bai Y, Li Z, Liu W, Gao D, Liu M, Zhang P. Biochanin A attenuates myocardial ischemia\/reperfusion injury through the TLR4\/NF-\u03baB\/NLRP3 signaling pathway. Acta Cir Bras 2019; 34: e201901104.","DOI":"10.1590\/s0102-865020190110000004"},{"key":"27","unstructured":"27. Wang Y, Wang L, Li JH, Zhao HW, Zhang FZ. Morphine alleviates myocardial ischemia\/reperfusion injury in rats by inhibiting TLR4\/NF-\u03baB signaling pathway. Eur Rev Med Pharmacol Sci 2019; 23: 8616-24."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Xu W, Zhang K, Zhang Y, Ma S, Jin D. Downregulation of DEC1 by RNA interference attenuates ischemia\/reperfusion-induced myocardial inflammation by inhibiting the TLR4\/NF-\u03baB signaling pathway. Exp Ther Med 2020; 20: 343-50.","DOI":"10.3892\/etm.2020.8706"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Bartel DP. Metazoan microRNAs. Cell 2018; 173: 20-51.","DOI":"10.1016\/j.cell.2018.03.006"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Pouyanrad S, Rahgozar S, Ghodousi ES. Dysregulation of miR-335-3p, targeted by NEAT1 and MALAT1 long non-coding RNAs, is associated with poor prognosis in childhood acute lymphoblastic leukemia. Gene 2019; 692: 35-43.","DOI":"10.1016\/j.gene.2019.01.003"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Yu Y, Wang L, Li Z, Zheng Y, Shi Z, Wang G. Long noncoding RNA CRNDE functions as a diagnostic and prognostic biomarker in osteosarcoma, as well as promotes its progression via inhibition of miR-335-3p. J Biochem Mol Toxicol 2021; 35: e22734.","DOI":"10.1002\/jbt.22734"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Fan J, Fan X, Guang H, <i>et al<\/i>. Upregulation of miR-335-3p by NF-\u03baB transcriptional regulation contributes to the induction of pulmonary arterial hypertension via APJ during hypoxia. Int J Biol Sci 2020; 16: 515-28.","DOI":"10.7150\/ijbs.34517"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Yu L, Hao Y, Xu C, Zhu G, Cai Y. LINC00969 promotes the degeneration of intervertebral disk by sponging miR-335-3p and regulating NLRP3 inflammasome activation. IUBMB Life 2019; 71: 611-8.","DOI":"10.1002\/iub.1989"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Raihan O, Brishti A, Molla MR, <i>et al<\/i>. The age-dependent elevation of miR-335-3p leads to reduced cholesterol and impaired memory in brain. Neuroscience 2018; 390: 160-73.","DOI":"10.1016\/j.neuroscience.2018.08.003"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Rocha DM, Caldas AP, Oliveira LL, Bressan J, Hermsdorff HH. Saturated fatty acids trigger TLR4-mediated inflammatory response. Atherosclerosis 2016; 244: 211-5.","DOI":"10.1016\/j.atherosclerosis.2015.11.015"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Zhang K, Zhou B, Wang Y, Rao L, Zhang L. The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis. Eur J Cancer 2013; 49: 946-54.","DOI":"10.1016\/j.ejca.2012.09.022"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Wang Y, Wang D, Jin Z. miR-27a suppresses TLR4-induced renal ischemia-reperfusion injury. Mol Med Rep 2019; 20: 967-76.","DOI":"10.3892\/mmr.2019.10333"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Yang J, Jiang H, Yang J, <i>et al<\/i>. Valsartan preconditioning protects against myocardial ischemia-reperfusion injury through TLR4\/NF-kappaB signaling pathway. Mol Cell Biochem 2009; 330: 39-46.","DOI":"10.1007\/s11010-009-0098-1"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Yin H, Tan Y, Wu X, <i>et al<\/i>. Association between TLR4 and PTEN involved in LPS-TLR4 signaling response. BioMed Res Int 2016; 2016: 6083178.","DOI":"10.1155\/2016\/6083178"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Kamo N, Ke B, Busuttil RW, Kupiec-Weglinski JW. PTEN-mediated Akt\/\u03b2-catenin\/FoxO1 signaling regulates innate immune responses in mouse liver ischemia\/reperfusion injury. Hepatology 2013; 57: 289-98.","DOI":"10.1002\/hep.25958"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Xu J, Yu D, Bai X, Zhang P. Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury. Bioengineered 2021; 12: 6674-86.","DOI":"10.1080\/21655979.2021.1957524"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Wu Z, Qi Y, Guo Z, Li P, Zhou D. miR-613 suppresses ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting the programmed cell death 10 gene. BioSci Trends 2016; 10: 251-7.","DOI":"10.5582\/bst.2016.01122"},{"key":"43","unstructured":"43. Wu N, Zhang X, Du S, Chen D, Che R. Upregulation of miR-335 ameliorates myocardial ischemia reperfusion injury via targeting hypoxia inducible factor 1-alpha subunit inhibitor. Am J Transl Res 2018; 10: 4082-94."},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Wu N, Zhang X, Bao Y, Yu H, Jia D, Ma C. Down-regulation of GAS5 ameliorates myocardial ischaemia\/reperfusion injury via the miR-335\/ROCK1\/AKT\/GSK-3\u03b2 axis. J Cell Mol Med 2019; 23: 8420-31.","DOI":"10.1111\/jcmm.14724"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Dai Y, Wang S, Chang S, <i>et al<\/i>. M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia\/reperfusion injury via inhibiting TXNIP and the TLR4\/NF-\u03baB\/NLRP3 inflammasome signaling pathway. J Mol Cell Cardiol 2020; 142: 65-79.","DOI":"10.1016\/j.yjmcc.2020.02.007"},{"key":"46","unstructured":"46. Zhou CN, Yao W, Gong YN, Li Y, Wang CH, Huo YF. 22-oxacalcitriol protects myocardial ischemia-reperfusion injury by suppressing NF-\u03baB\/TNF-\u03b1 pathway. Eur Rev Med Pharmacol Sci 2019; 23: 5495-502."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Zhu QQ, Lai MC, Chen TC, <i>et al<\/i>. LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increasing ubiquitination of thioredoxin-interacting protein. Life Sci 2021; 119255.","DOI":"10.1016\/j.lfs.2021.119255"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Guo T, Liu Y, Ren X, Wang W, Liu H. Promoting role of long non-coding RNA small nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a\/CXC Chemokine Ligand 13 (CXCL13)\/ERK\/MEK Axis. Med Sci Monit 2020; 26: e923610.","DOI":"10.12659\/MSM.923610"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Tong J, Ma X, Yu H, Yang J. SNHG15: a promising cancer-related long noncoding RNA. Cancer Manag Res 2019; 11: 5961-9.","DOI":"10.2147\/CMAR.S208054"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/63\/3\/63_21-511\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T04:20:54Z","timestamp":1654316454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/63\/3\/63_21-511\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,30]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.21-511","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,30]]},"article-number":"21-511"}}