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Sulo G, Igland J, Sulo E, \u00d8verland S, Egeland GM, Vollset SE, Tell GS. Mortality following first-time hospitalization with acute myocardial infarction in Norway, 2001-2014: time trends, underlying causes and place of death. Int J Cardiol 2019; 294: 6-12.","DOI":"10.1016\/j.ijcard.2019.07.084"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Li Z, Huang C, Bao C, <i>et al<\/i>. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol 2015; 22: 256-64.","DOI":"10.1038\/nsmb.2959"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLOS ONE 2012; 7: e30733.","DOI":"10.1371\/journal.pone.0030733"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hentze MW, Preiss T. Circular RNAs: splicing&apos;s enigma variations. EMBO J 2013; 32: 923-5.","DOI":"10.1038\/emboj.2013.53"},{"key":"5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","year":"2013","unstructured":"5. Memczak S, Jens M, Elefsinioti A, <i>et al<\/i>. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013; 495: 333-8.","journal-title":"?Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Geng HH, Li R, Su YM, <i>et al<\/i>. The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. Plos One 2016; 11: e0151753.","DOI":"10.1371\/journal.pone.0151753"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Zhang M, Wang Z, Cheng Q, <i>et al<\/i>. Circular RNA (circRNA) CDYL induces myocardial regeneration by ceRNA after myocardial infarction. Med Sci Monit 2020; 26: e923188.","DOI":"10.12659\/MSM.923188"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Zhao B, Li G, Peng J, <i>et al<\/i>. CircMACF1 attenuates acute myocardial infarction through miR-500b-5p-EMP1 axis. J Cardiovasc Transl Res 2021; 14: 161-72.","DOI":"10.1007\/s12265-020-09976-5"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zhao C, Liu J, Ge W, <i>et al<\/i>. Identification of regulatory circRNAs involved in the pathogenesis of acute myocardial infarction. Front Genet 2020; 11: 626492.","DOI":"10.3389\/fgene.2020.626492"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Liu Y, Liu Y, Li G, Chen Z, Gu G. Ghrelin protects the myocardium with hypoxia\/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. 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Adult respiratory distress syndrome in the course of acute myocardial infarction. Chest 1980; 77: 161-4.","DOI":"10.1378\/chest.77.2.161"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Zhang HD, Jiang LH, Sun DW, Hou JC, Ji ZL. CircRNA: a novel type of biomarker for cancer. Breast Cancer 2018; 25: 1-7.","DOI":"10.1007\/s12282-017-0793-9"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Li Y, Ren S, Xia J, Wei Y, Xi Y. EIF4A3-induced circ-BNIP3 aggravated hypoxia-induced injury of H9c2 cells by targeting miR-27a-3p\/BNIP3. Mol Ther Nucleic Acids 2020; 19: 533-45.","DOI":"10.1016\/j.omtn.2019.11.017"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Lei D, Wang Y, Zhang L, Wang Z. Circ_0010729 regulates hypoxia-induced cardiomyocyte injuries by activating TRAF5 via sponging miR-27a-3p. Life Sci 2020; 262: 118511.","DOI":"10.1016\/j.lfs.2020.118511"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Tan J, Pan W, Chen H, <i>et al<\/i>. 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