{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:50:22Z","timestamp":1785444622855,"version":"3.56.0"},"reference-count":36,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2023,11,30]]},"DOI":"10.1536\/ihj.23-333","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T22:13:11Z","timestamp":1699913591000},"page":"1125-1132","source":"Crossref","is-referenced-by-count":7,"title":["Circ_0004771 Promotes Hypoxia\/Reoxygenation Induced Cardiomyocyte Injury via Activation of Mitogen-Activated Protein Kinase Signaling Pathway"],"prefix":"10.1536","volume":"64","author":[{"given":"Chun-jun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Wuhan Asia General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wuhan Asia General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wuhan Asia General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-peng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wuhan Asia General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wuhan Asia General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wuhan Asia General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Lianou A, Rallis D, Baltogianni M, Vlahos A, Milionis H, Giapros V. Biomarkers of cardiovascular disease risk in the neonatal population. J Dev Orig Health Dis 2023; 14: 155-65.","DOI":"10.1017\/S2040174422000459"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ibanez B, James S, Agewall S, <i>et al<\/i>. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2018; 39: 119-77.","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"3","first-page":"e146","volume":"135","year":"2017","unstructured":"3. Benjamin EJ, Blaha MJ, Chiuve SE, <i>et al<\/i>. Heart disease and stroke statistics-2017 update: A report from the American Heart Association. Circulation 2017; 135: e146-603.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Gulati R, Behfar A, Narula J, <i>et al<\/i>. Acute myocardial infarction in young individuals. Mayo Clin Proc 2020; 95: 136-56.","DOI":"10.1016\/j.mayocp.2019.05.001"},{"key":"5","unstructured":"5. Tawfik MK, Ghattas MH, Abo-Elmatty DM, Abdel-Aziz NA. Atorvastatin restores the balance between pro-inflammatory and anti-inflammatory mediators in rats with acute myocardial infarction. Eur Rev Med Pharmacol Sci 2010; 14: 499-506."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Thiele H, Akin I, Sandri M, <i>et al<\/i>. PCI strategies in patients with acute myocardial infarction and cardiogenic shock. N Engl J Med 2017; 377: 2419-32.","DOI":"10.1056\/NEJMoa1710261"},{"key":"7","unstructured":"7. Task Force on the management of STseamiotESoC, Steg PG, James SK, <i>et al<\/i>. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012; 33: 2569-619."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Chen Y, Li C, Tan C, Liu X. Circular RNAs: A new frontier in the study of human diseases. J Med Genet 2016; 53: 359-65.","DOI":"10.1136\/jmedgenet-2016-103758"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ebbesen KK, Kjems J, Hansen TB. Circular RNAs: Identification, biogenesis and function. Biochim Biophys Acta 2016; 1859: 163-8.","DOI":"10.1016\/j.bbagrm.2015.07.007"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wu J, Qi X, Liu L, <i>et al<\/i>. Emerging epigenetic regulation of circular RNAs in human cancer. Mol Ther Nucleic Acids 2019; 16: 589-96.","DOI":"10.1016\/j.omtn.2019.04.011"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Fan X, Weng X, Zhao Y, Chen W, Gan T, Xu D. Circular RNAs in cardiovascular disease: An overview. Biomed Res Int 2017; 2017: 5135781.","DOI":"10.1155\/2017\/5135781"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Zhang M, Wang Z, Cheng Q, <i>et al<\/i>. Circular RNA (circRNA) CDYL induces myocardial regeneration by ceRNA after myocardial infarction. Med Sci Monit 2020; 26: e923188.","DOI":"10.12659\/MSM.923188"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Geng HH, Li R, Su YM, <i>et al<\/i>. The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. PLOS ONE 2016; 11: e0151753.","DOI":"10.1371\/journal.pone.0151753"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chen TP, Zhang NJ, Wang HJ, Hu SG, Geng X. Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184\/TRADD axis. Mol Med 2021; 27: 21.","DOI":"10.1186\/s10020-021-00275-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Zhou S, Guo Z, Zhou C, Zhang Y, Wang S. circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595\/SEMA4D axis and PI3K\/AKT pathway. Cancer Cell Int 2021; 21: 250.","DOI":"10.1186\/s12935-021-01907-x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Du Z. CircNRIP1: An emerging star in multiple cancers. Pathol Res Pract 2023; 241: 154281.","DOI":"10.1016\/j.prp.2022.154281"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Wu J, Li C, Lei Z, <i>et al<\/i>. Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in acute myocardial infarction. Front Cardiovasc Med 2022; 9: 850991.","DOI":"10.3389\/fcvm.2022.850991"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Wu X, Wu J, Yan X, Zhang Y. Enhancement of myocardial function and reduction of injury with levosimendan after percutaneous coronary intervention for acute myocardial infarction: a pilot study. Cardiology 2014; 128: 202-8.","DOI":"10.1159\/000360933"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Ouyang M, Lu J, Ding Q, Qin T, Peng C, Guo Q. Knockdown of long non-coding RNA PVT1 protects human AC16 cardiomyocytes from hypoxia\/reoxygenation-induced apoptosis and autophagy by regulating miR-186\/Beclin-1 axis. Gene 2020; 754: 144775.","DOI":"10.1016\/j.gene.2020.144775"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Rodriguez-Losada N, Jimenez-Navarro MF, Fernandez B, <i>et al<\/i>. Resident and non-resident stem cells in acute myocardial infarction. Cardiovasc Hematol Disord Drug Targets 2010; 10: 202-15.","DOI":"10.2174\/1871529X11006030202"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zhao B, Li G, Peng J, <i>et al<\/i>. CircMACF1 attenuates acute myocardial infarction through miR-500b-5p-EMP1 axis. J Cardiovasc Transl Res 2021; 14: 161-72.","DOI":"10.1007\/s12265-020-09976-5"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wang S, Li L, Deng W, Jiang M. CircRNA MFACR is upregulated in myocardial infarction and downregulates miR-125b to promote cardiomyocyte apoptosis induced by hypoxia. J Cardiovasc Pharmacol 2021; 78: 802-8.","DOI":"10.1097\/FJC.0000000000001123"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Zhao Y, Wang S, Liu S, Yan Q, Li Y, Liu Y. CircHSPG2 absence weakens hypoxia-induced dysfunction in cardiomyocytes by targeting the miR-25-3p\/PAWR axis. Cardiovasc Diagn Ther 2022; 12: 589-602.","DOI":"10.21037\/cdt-22-197"},{"key":"24","unstructured":"24. Chen P, Zhou C, Li B, Yang C. Circular RNA MGAT1 regulates cell proliferation and apoptosis in hypoxia-induced cardiomyocytes through miR-34a\/YAP1 axis. Int J Clin Exp Pathol 2020; 13: 2474-86."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ding X, Zheng J, Cao M. Circ_0004771 accelerates cell carcinogenic phenotypes via suppressing miR-1253-mediated DDAH1 inhibition in breast cancer. Cancer Manag Res 2021; 13: 1-11.","DOI":"10.2147\/CMAR.S273783"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Gonzalez-Montero J, Brito R, Gajardo AI, Rodrigo R. Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities. World J Cardiol 2018; 10: 74-86.","DOI":"10.4330\/wjc.v10.i9.74"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Zimmerman JJ. Defining the role of oxyradicals in the pathogenesis of sepsis. Crit Care Med 1995; 23: 616-7.","DOI":"10.1097\/00003246-199504000-00003"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Zheng H, Huang S, Wei G, <i>et al<\/i>. CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. Mol Ther 2022; 30: 3477-98.","DOI":"10.1016\/j.ymthe.2022.06.016"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Li J, Jiang R, Hou Y, Lin A. Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4\/miR-497-5p\/MG53 pathway. Biochem Biophys Res Commun 2022; 618: 133-40.","DOI":"10.1016\/j.bbrc.2022.05.094"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Liu J, Dong W, Gao C, Meng Y. Salvianolic acid B protects cardiomyocytes from ischemia\/reperfusion injury by mediating circTRRAP\/miR-214-3p\/SOX6 axis. Int Heart J 2022; 63: 1176-86.","DOI":"10.1536\/ihj.22-102"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wang A, Zhang H, Liang Z, <i>et al<\/i>. U0126 attenuates ischemia\/reperfusion-induced apoptosis and autophagy in myocardium through MEK\/ERK\/EGR-1 pathway. Eur J Pharmacol 2016; 788: 280-5.","DOI":"10.1016\/j.ejphar.2016.06.038"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Sun L, Fan H, Yang L, Shi L, Liu Y. Tyrosol prevents ischemia\/reperfusion-induced cardiac injury in H9c2 cells: Involvement of ROS, Hsp70, JNK and ERK, and apoptosis. Molecules 2015; 20: 3758-75.","DOI":"10.3390\/molecules20033758"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hermann R, Mestre Cordero VE, Fernandez Pazos MLM, <i>et al<\/i>. Differential effects of AMP-activated protein kinase in isolated rat atria subjected to simulated ischemia-reperfusion depending on the energetic substrates available. Pflugers Arch 2018; 470: 367-83.","DOI":"10.1007\/s00424-017-2075-y"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Croft A, Tay KH, Boyd SC, <i>et al<\/i>. Oncogenic activation of MEK\/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress. J Invest Dermatol 2014; 134: 488-97.","DOI":"10.1038\/jid.2013.325"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Jiang CC, Chen LH, Gillespie S, <i>et al<\/i>. Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer Res 2007; 67: 9750-61.","DOI":"10.1158\/0008-5472.CAN-07-2047"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Zhao L, Jiang S, Wu N, Shi E, Yang L, Li Q. MiR-17-5p-mediated endoplasmic reticulum stress promotes acute myocardial ischemia injury through targeting Tsg101. Cell Stress Chaperones 2021; 26: 77-90.","DOI":"10.1007\/s12192-020-01157-2"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/64\/6\/64_23-333\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T04:09:48Z","timestamp":1701490188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/64\/6\/64_23-333\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.23-333","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]},"article-number":"23-333"}}