{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:05:06Z","timestamp":1790265906500,"version":"4.1.0"},"reference-count":33,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2024,5,31]]},"DOI":"10.1536\/ihj.23-454","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T22:09:55Z","timestamp":1715724595000},"page":"380-385","source":"Crossref","is-referenced-by-count":5,"title":["A Randomized Controlled Study of Enhanced External Counterpulsation with Cardiac Rehabilitation in Patients with Nonobstructive Coronary Artery Disease and Coronary Microvascular Dysfunction"],"prefix":"10.1536","volume":"65","author":[{"given":"Yuanzhuo","family":"Zhang","sequence":"first","affiliation":[{"name":"Bengbu Medical College, Fuyang Peoples Hospital Affiliated to Bengbu Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yin","sequence":"additional","affiliation":[{"name":"Bengbu Medical College, Fuyang Peoples Hospital Affiliated to Bengbu Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ren","sequence":"additional","affiliation":[{"name":"Bengbu Medical College, Fuyang Peoples Hospital Affiliated to Bengbu Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Kunadian V, Chieffo A, Camici PG, <i>et al<\/i>. An EAPCI Expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology working group on coronary pathophysiology and microcirculation endorsed by coronary vasomotor disorders international study group. EuroIntervention 2021; 16: 1049-69.","DOI":"10.4244\/EIJY20M07_01"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Zhai C, Fan H, Zhu Y, Chen Y, Shen L. Coronary functional assessment in non-obstructive coronary artery disease: present situation and future direction. Front Cardiovasc Med 2022; 9: 934279.","DOI":"10.3389\/fcvm.2022.934279"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ong P, Camici PG, Beltrame JF, <i>et al<\/i>. International standardization of diagnostic criteria for microvascular angina. Int J Cardiol 2018; 250: 16-20.","DOI":"10.1016\/j.ijcard.2017.08.068"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Radico F, Zimarino M, Fulgenzi F, <i>et al<\/i>. Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis. Eur Heart J 2018; 39: 2135-46.","DOI":"10.1093\/eurheartj\/ehy185"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bairey Merz CN, Pepine CJ, Shimokawa H, Berry C. Treatment of coronary microvascular dysfunction. Cardiovasc Res 2020; 116: 856-70.","DOI":"10.1093\/cvr\/cvaa006"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Rehan R, Yong A, Ng M, Weaver J, Puranik R. Coronary microvascular dysfunction: a review of recent progress and clinical implications. Front Cardiovasc Med 2023; 10: 1111721.","DOI":"10.3389\/fcvm.2023.1111721"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Rayegani SM, Heidari S, Maleki M, <i>et al<\/i>. Safety and effectiveness of enhanced external counterpulsation (EECP) in refractory angina patients: a systematic reviews and meta-analysis. J Cardiovasc Thorac Res 2021; 13: 265-76.","DOI":"10.34172\/jcvtr.2021.50"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Loh PH, Cleland JG, Louis AA, <i>et al<\/i>. Enhanced external counterpulsation in the treatment of chronic refractory angina: a long-term follow-up outcome from the International Enhanced External Counterpulsation Patient Registry. Clin Cardiol 2008; 31: 159-64.","DOI":"10.1002\/clc.20117"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Vilela EM, Ladeiras-Lopes R, <i>et al<\/i>. Current role and future perspectives of cardiac rehabilitation in coronary heart disease. World J Cardiol 2021; 13: 695-709.","DOI":"10.4330\/wjc.v13.i12.695"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Schumann CL, Mathew RC, Dean JL, <i>et al<\/i>. Functional and economic impact of INOCA and influence of coronary microvascular dysfunction. JACC Cardiovasc Imaging 2021; 14: 1369-79.","DOI":"10.1016\/j.jcmg.2021.01.041"},{"key":"11","unstructured":"11. Sub-Committee of Prevention of Chinese Society of Cardiology of Chinese Medical Association, Cardiovascular Committee of Chinese Association of Rehabilitation Medicine, Sub-Committee of Prevention of Chinese Society of Cardiology of Chinese Medical Association Cardiovascular Committee of Chinese Association of Rehabilitation Medicine. Chinese expert consensus on exercise-based rehabilitation for patients with coronary heart disease. Zhonghua Xin Xue Guan Bing Za Zhi 2015; 43: 575-88."},{"key":"12","unstructured":"12. [Guidelines for cardiovascular rehabilitation and secondary prevention in China 2018 simplified edition]. Zhonghua Nei Ke Za Zhi 2018; 57: 802-10."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lin S, Xiao-Ming W, Gui-Fu W. Expert consensus on the clinical application of enhanced external counterpulsation in elderly people (2019). Aging Med (Milton) 2020; 3: 16-24.","DOI":"10.1002\/agm2.12097"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Jieqin Z, Shuling L, Hairong C, <i>et al<\/i>. Efficacy and safety of Guhong injection for treating coronary microvascular disease: study protocol for a randomized controlled trial. Trials 2020; 21: 75.","DOI":"10.1186\/s13063-019-3990-3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Padro T, Manfrini O, Bugiardini R, <i>et al<\/i>. ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on &apos;coronary microvascular dysfunction in cardiovascular disease&apos;. Cardiovasc Res 2020; 116: 741-55.","DOI":"10.1093\/cvr\/cvaa003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Marinescu MA, L\u00f6ffler AI, Ouellette M, Smith L, Kramer CM, Bourque JM. Coronary microvascular dysfunction, microvascular angina, and treatment strategies. JACC Cardiovasc Imaging 2015; 8: 210-20.","DOI":"10.1016\/j.jcmg.2014.12.008"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Jan R, Khan A, Zahid S, <i>et al<\/i>. The Effect of enhanced external counterpulsation (EECP) on quality of life in patient with coronary artery disease not amenable to PCI or CABG. Cureus 2020; 12: e7987.","DOI":"10.7759\/cureus.7987"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Zhang Y, Chen Z, Mai Z, <i>et al<\/i>. Acute hemodynamic responses to enhanced external counterpulsation in patients with coronary artery disease. Front Cardiovasc Med 2021; 8: 721140.","DOI":"10.3389\/fcvm.2021.721140"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yang H, Song L, Ning X, <i>et al<\/i>. Enhanced external counterpulsation ameliorates endothelial dysfunction and elevates exercise tolerance in patients with coronary artery disease. Front Cardiovasc Med 2022; 9: 997109.","DOI":"10.3389\/fcvm.2022.997109"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Li B, Xu K, Liu J, <i>et al<\/i>. A numerical model for simulating the hemodynamic effects of enhanced external counterpulsation on coronary arteries. Front Physiol 2021; 12: 656224.","DOI":"10.3389\/fphys.2021.656224"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Shaw J, Anderson T. Coronary endothelial dysfunction in non-obstructive coronary artery disease: risk, pathogenesis, diagnosis and therapy. Vasc Med 2016; 21: 146-55.","DOI":"10.1177\/1358863X15618268"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Thijssen DHJ, Bruno RM, van Mil ACCM, <i>et al<\/i>. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J 2019; 40: 2534-47.","DOI":"10.1093\/eurheartj\/ehz350"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Vancheri F, Longo G, Vancheri S, Henein M. Coronary microvascular dysfunction. J Clin Med 2020; 9: 2880.","DOI":"10.3390\/jcm9092880"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Pries AR, Reglin B. Coronary microcirculatory pathophysiology: can we afford it to remain a black box? Eur Heart J 2017; 38: 478-88.","DOI":"10.1093\/eurheartj\/ehv760"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Del Buono MG, Montone RA, Camilli M, <i>et al<\/i>. Coronary microvascular dysfunction across the spectrum of cardiovascular diseases: JACC state-of-the-art review. J Am Coll Cardiol 2021; 78: 1352-71.","DOI":"10.1016\/j.jacc.2021.07.042"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Liang J, Shi J, Wei W, Wu G. External counterpulsation attenuates hypertensive vascular injury through enhancing the function of endothelial progenitor cells. Front Physiol 2020; 11: 590585.","DOI":"10.3389\/fphys.2020.590585"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Zhou Y, Zhu X, Cui H, <i>et al<\/i>. The role of the VEGF family in coronary heart disease. Front Cardiovasc Med 2021; 8: 738325.","DOI":"10.3389\/fcvm.2021.738325"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Pajula J, L\u00e4hteenvuo J, L\u00e4hteenvuo M, <i>et al<\/i>. Adenoviral VEGF-D\u0394N \u0394C gene therapy for myocardial ischemia. Front Bioeng Biotechnol 2022; 10: 999226.","DOI":"10.3389\/fbioe.2022.999226"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Shaker SR, Al-Amran F, Fatima G, Al-Aubaid H, Hadi NR. Trimetazidine improves the outcome of EECP therapy in patients with refractory angina pectoris. Med Arch 2020; 74: 199-204.","DOI":"10.5455\/medarh.2020.74.199-204"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wang Z, Yao C, Huang L, <i>et al<\/i>. Enhanced external counterpulsation improves dysfunction of forearm muscle caused by radial artery occlusion. Front Cardiovasc Med 2023; 10: 1115494.","DOI":"10.3389\/fcvm.2023.1115494"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Dibben G, Faulkner J, Oldridge N, <i>et al<\/i>. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 2021; 11: CD001800.","DOI":"10.1002\/14651858.CD001800.pub4"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Bjarnason-Wehrens B, Nebel R, Jensen K, <i>et al<\/i>. Exercise-based cardiac rehabilitation in Patients with reduced left ventricular ejection fraction: the Cardiac Rehabilitation Outcome Study in Heart Failure (CROS-HF): a systematic review and meta-analysis. Eur J Prev Cardiol 2020; 27: 929-52.","DOI":"10.1177\/2047487319854140"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Baldasseroni S, Silverii MV, Herbst A, <i>et al<\/i>. Predictors of physical frailty improvement in older Patients enrolled in a multidisciplinary cardiac rehabilitation program. Heart Vessels 2023; 38: 1056-64.","DOI":"10.1007\/s00380-023-02254-9"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/65\/3\/65_23-454\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T04:14:32Z","timestamp":1717215272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/65\/3\/65_23-454\/_article"}},"subtitle":["Clinical Durative Effect"],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.23-454","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"article-number":"23-454"}}