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Conte MS, Bradbury AW, Kolh P, <i>et al<\/i>. Global vascular guidelines on the management of chronic limb-threatening ischemia. J Vasc Surg 2019; 69: 3S-125S.e40."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Aboyans V, Ricco JB, Bartelink ML, <i>et al<\/i>. 2017 ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries. Endorsed by: the European Stroke Organization (ESO). The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). Eur Heart J 2018; 39: 763-816.","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Iida O, Nakamura M, Yamauchi Y, <i>et al<\/i>. Endovascular treatment for infrainguinal vessels in patients with critical limb ischemia: OLIVE registry, a prospective, multicenter study in Japan with 12-month follow-up. Circ Cardiovasc Interv 2013; 6: 68-76.","DOI":"10.1161\/CIRCINTERVENTIONS.112.975318"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Iida O, Nakamura M, Yamauchi Y, <i>et al<\/i>. 3-Year outcomes of the OLIVE Registry, a prospective multicenter study of patients with critical limb ischemia: a prospective, multi-center, three-year follow-up study on endovascular treatment for infra-inguinal vessel in patients with critical limb ischemia. JACC Cardiovasc Interv 2015; 8: 1493-502.","DOI":"10.1016\/j.jcin.2015.07.005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Vierthaler L, Callas PW, Goodney PP, <i>et al<\/i>. Determinants of survival and major amputation after peripheral endovascular intervention for critical limb ischemia. J Vasc Surg 2015; 62: 655-64.e8.","DOI":"10.1016\/j.jvs.2015.04.391"},{"key":"6","unstructured":"6. Melillo E, Micheletti L, Nuti M, <i>et al<\/i>. Long-term clinical outcomes in critical limb ischemia--a retrospective study of 181 patients. Eur Rev Med Pharmacol Sci 2016; 20: 502-8."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Fridh EB, Andersson M, Thuresson M, <i>et al<\/i>. Amputation rates, mortality, and pre-operative comorbidities in patients revascularised for intermittent claudication or critical limb ischaemia: a population based study. Eur J Vasc Endovasc Surg 2017; 54: 480-6.","DOI":"10.1016\/j.ejvs.2017.07.005"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Iida O, Takahara M, Soga Y, <i>et al<\/i>. Three-year outcomes of surgical versus endovascular revascularization for critical limb ischemia: the SPINACH study (surgical reconstruction versus peripheral intervention in patients with critical limb ischemia). 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J Vasc Surg 2013; 57: 1-7.","DOI":"10.1016\/j.jvs.2012.04.074"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Soga Y, Iida O, Takahaera M, <i>et al<\/i>. Two-year life expectancy in patients with critical limb ischemia. JACC Cardiovasc Interv 2014; 7: 1444-9.","DOI":"10.1016\/j.jcin.2014.06.018"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Miyata T, Mii S, Kumamaru H, <i>et al<\/i>. Risk prediction model for early outcomes of revascularization for chronic limb-threatening ischaemia. Br J Surg 2021; 108: 941-50.","DOI":"10.1093\/bjs\/znab036"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Walter DH, Krankenberg H, Balzer JO, <i>et al<\/i>. Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA). 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