{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:29:00Z","timestamp":1764390540225,"version":"3.46.0"},"reference-count":41,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2025,11,29]]},"DOI":"10.1536\/ihj.24-790","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T22:08:20Z","timestamp":1764367700000},"page":"986-994","source":"Crossref","is-referenced-by-count":0,"title":["Silencing of MiR-329-3p Protects against Myocardial Ischemia-Reperfusion Injury by Regulating the Wnt\/\u03b2-catenin Pathway via Nemo-Like Kinase"],"prefix":"10.1536","volume":"66","author":[{"given":"Longfei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maozhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Algowhary M. Association between age and infection in patients with acute ST-elevation myocardial infarction. Egypt Heart J 2021; 73: 12.","DOI":"10.1186\/s43044-021-00137-w"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Sun M, Guo M, Ma G, <i>et al<\/i>. MicroRNA-30c-5p protects against myocardial ischemia\/reperfusion injury via regulation of Bach1\/Nrf2. Toxicol Appl Pharmacol 2021; 426: 115637.","DOI":"10.1016\/j.taap.2021.115637"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Li C, Fang M, Lin Z, Wang W, Li X. MicroRNA-24 protects against myocardial ischemia-reperfusion injury via the NF-kappaB\/TNF-alpha pathway. Exp Ther Med 2021; 22: 1288.","DOI":"10.3892\/etm.2021.10723"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Li C, Pu Y, Wang D, <i>et al<\/i>. MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis. Int Heart J 2024; 65: 300-7.","DOI":"10.1536\/ihj.23-269"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. He Y, Jiang Y, Wu F, Zhang X, Liang S, Ye Z. Platelet Microparticle-Derived MiR-320b Inhibits Hypertension with Atherosclerosis Development by Targeting ETFA. Int Heart J 2024; 65: 329-38.","DOI":"10.1536\/ihj.23-365"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Liu XM, Zhang Z, Zhong J, <i>et al<\/i>. Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K\/Akt\/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression. Eur J Pharmacol 2022; 916: 174719.","DOI":"10.1016\/j.ejphar.2021.174719"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wang G, Feng L, Liu C, Han Z, Chen X. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. Int Heart J 2024; 65: 528-36.","DOI":"10.1536\/ihj.23-485"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Liang G, Guo C, Tang H, Zhang M. miR-30a-5p attenuates hypoxia\/reoxygenation-induced cardiomyocyte apoptosis by regulating PTEN protein expression and activating PI3K\/Akt signaling pathway. BMC Cardiovasc Disord 2024; 24: 236.","DOI":"10.1186\/s12872-024-03900-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Mo C, Tang X, Wei Y, <i>et al<\/i>. miRNA-148a-3p targets to regulate the lipid metabolism gene SOCS3 to reduce myocardial ischemia\/reperfusion injury. Minerva Cardiol Angiol 2025; 73: 136-46.","DOI":"10.23736\/S2724-5683.24.06578-5"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Bai G, Yang J, Liao W, <i>et al<\/i>. MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction. Animal Model Exp Med 2024; 7: 408-18.","DOI":"10.1002\/ame2.12418"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Purvis N, Kumari S, Chandrasekera D, <i>et al<\/i>. Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia 2021; 64: 1422-35.","DOI":"10.1007\/s00125-021-05405-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Derda AA, Pfanne A, Bar C, <i>et al<\/i>. Blood-based microRNA profiling in patients with cardiac amyloidosis. PLoS One 2018; 13: e0204235.","DOI":"10.1371\/journal.pone.0204235"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lu GF, Geng F, Deng LP, <i>et al<\/i>. Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary Arterial Hypertension Rats. Hypertension 2022; 79: 2465-79.","DOI":"10.1161\/HYPERTENSIONAHA.122.19183"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. He J, Xuan X, Jiang M, Li J, Li N, Nie T. Long non-coding RNA SNHG1 relieves microglia activation by downregulating miR-329-3p expression in an <i>in vitro<\/i> model of cerebral infarction. Exp Ther Med 2021; 22: 1148.","DOI":"10.3892\/etm.2021.10581"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Zhang R, Wang J, Liu B, <i>et al<\/i>. Differentially expressed lncRNAs, miRNAs and mRNAs with associated ceRNA networks in a mouse model of myocardial ischemia\/reperfusion injury. Mol Med Rep 2020; 22: 2487-95.","DOI":"10.3892\/mmr.2020.11300"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Li K, Zhou P, Li S, Zheng S, Wang D. MicroRNA-29b reduces myocardial ischemia-reperfusion injury in rats via down-regulating PTEN and activating the Akt\/eNOS signaling pathway. J Thromb Thrombolysis 2022; 53: 123-35.","DOI":"10.1007\/s11239-021-02535-y"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Li Y, Li Z, Liu J, Liu Y, Miao G. miR-190-5p Alleviates Myocardial Ischemia-Reperfusion Injury by Targeting PHLPP1. Dis Markers 2021; 2021: 8709298.","DOI":"10.1155\/2021\/8709298"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Bei Y, Lu D, Bar C, <i>et al<\/i>. miR-486 attenuates cardiac ischemia\/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection. Mol Ther 2022; 30: 1675-91.","DOI":"10.1016\/j.ymthe.2022.01.031"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Goossens EAC, Zhang L, de Vries MR, Jukema JW, Quax PHA, Nossent AY. Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p. Int J Mol Sci 2021; 22: 12678.","DOI":"10.3390\/ijms222312678"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Zhu L, Duan W, Yang B, Wang L. Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I\/R injury in an age-independent manner. Int J Med Sci 2023; 20: 1562-9.","DOI":"10.7150\/ijms.87174"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yang C, Yu P, Yang F, <i>et al<\/i>. PSMB4 inhibits cardiomyocyte apoptosis via activating NF-kappaB signaling pathway during myocardial ischemia\/reperfusion injury. J Mol Histol 2021; 52: 693-703.","DOI":"10.1007\/s10735-021-09977-x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Gao L, Zhang L, He F, <i>et al<\/i>. Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity. Int J Nanomedicine 2021; 16: 3581-98.","DOI":"10.2147\/IJN.S313153"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Chen Z, Cao Y, Huang J, <i>et al<\/i>. NLK suppresses MAVS-mediated signaling in black carp antiviral innate immunity. Dev Comp Immunol 2021; 122: 104105.","DOI":"10.1016\/j.dci.2021.104105"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Song J, Liu Q, Han L, <i>et al<\/i>. Hsa_circ_0009092\/miR-665\/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment. J Exp Clin Cancer Res 2023; 42: 319.","DOI":"10.1186\/s13046-023-02887-8"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Suwei D, Liang Z, Zhimin L, <i>et al<\/i>. NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin. J Hematol Oncol 2015; 8: 120.","DOI":"10.1186\/s13045-015-0203-8"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Huang L, Sun J, Ma Y, Chen H, Tian C, Dong M. MSI2 regulates NLK-mediated EMT and PI3K\/AKT\/mTOR pathway to promote pancreatic cancer progression. Cancer Cell Int 2024; 24: 273.","DOI":"10.1186\/s12935-024-03444-9"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Huang Y, Yang Y, He Y, Huang C, Meng X, Li J. MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK). Curr Pharm Des 2016; 22: 4868-75.","DOI":"10.2174\/1381612822666160210143047"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ali Sheikh MS. Overexpression of miR-375 Protects Cardiomyocyte Injury following Hypoxic-Reoxygenation Injury. Oxid Med Cell Longev 2020; 2020: 7164069.","DOI":"10.1155\/2020\/7164069"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Assmus B, Iwasaki M, Schachinger V, <i>et al<\/i>. Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow. Eur Heart J 2012; 33: 1911-9.","DOI":"10.1093\/eurheartj\/ehr388"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Moon J, Zhou H, Zhang LS, <i>et al<\/i>. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist. Proc Natl Acad Sci U S A 2017; 114: 1649-54.","DOI":"10.1073\/pnas.1621346114"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Meyer IS, Li X, Meyer C, <i>et al<\/i>. Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response. Int J Mol Sci 2022; 23: 12252.","DOI":"10.3390\/ijms232012252"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Liu L, Sun Y, Wang Y, Xin J, Chen W. [D-Ala2, D-Leu5]-enkephalin (DADLE) provides protection against myocardial ischemia reperfusion injury by inhibiting Wnt\/beta-Catenin pathway. BMC Cardiovasc Disord 2024; 24: 115.","DOI":"10.1186\/s12872-024-03790-6"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Li X, Guo L, Wang J, Yang X. Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury. Eur J Med Res 2023; 28: 84.","DOI":"10.1186\/s40001-023-01001-0"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Li M, Wang H, Huang T, <i>et al<\/i>. TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J Biol Chem 2010; 285: 13397-404.","DOI":"10.1074\/jbc.M109.083246"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Masoumi KC, Daams R, Sime W, <i>et al<\/i>. NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling. Mol Biol Cell 2017; 28: 346-55.","DOI":"10.1091\/mbc.e16-07-0547"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Zhou D, Wang Y, Gui Y, <i>et al<\/i>. Non-canonical Wnt\/calcium signaling is protective against podocyte injury and glomerulosclerosis. Kidney Int 2022; 102: 96-107.","DOI":"10.1016\/j.kint.2022.02.029"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Lv L, Wan C, Chen B, <i>et al<\/i>. Nemo-like kinase (NLK) inhibits the progression of NSCLC via negatively modulating WNT signaling pathway. J Cell Biochem 2014; 115: 81-92.","DOI":"10.1002\/jcb.24635"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Liu Z, Diep C, Mao T, <i>et al<\/i>. MicroRNA-92b promotes tumor growth and activation of NF-kappaB signaling via regulation of NLK in oral squamous cell carcinoma. Oncol Rep 2015; 34: 2961-8.","DOI":"10.3892\/or.2015.4323"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Song G, Li L, Yang Y. MicroRNA-329-3p alleviates high glucose-induced endothelial cell injury via inhibition of the TLR4\/TRAF6\/NF-kappaB signaling pathway. Exp Ther Med 2021; 21: 29.","DOI":"10.3892\/etm.2020.9461"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Chen J, Feng S, Li L, Qiu S, Jin Y, Sun Y. Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia. Mol Med 2022; 28: 77.","DOI":"10.1186\/s10020-022-00477-6"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Guo X, Wang Y. LncRNA TMPO-AS1 promotes hepatocellular carcinoma cell proliferation, migration and invasion through sponging miR-329-3p to stimulate FOXK1-mediated AKT\/mTOR signaling pathway. Cancer Med 2020; 9: 5235-46.","DOI":"10.1002\/cam4.3046"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/66\/6\/66_24-790\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T03:54:38Z","timestamp":1764388478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/66\/6\/66_24-790\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.24-790","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"type":"print","value":"1349-2365"},{"type":"electronic","value":"1349-3299"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"article-number":"24-790"}}