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Serum uric acid is independently associated with impaired nitroglycerine-induced vasodilation of the brachial artery in women. Hypertens Res 2025; 48: 6-14.","DOI":"10.1038\/s41440-024-01972-5"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Miao DM, Ye P, Xiao WK, Gao P, Zhang JY, Wu HM. Influence of low high-density lipoprotein cholesterol on arterial stiffening and left ventricular diastolic dysfunction in essential hypertension. J Clin Hypertens (Greenwich) 2011; 13: 710-5.","DOI":"10.1111\/j.1751-7176.2011.00501.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Wang H, Ba Y, Gao X, <i>et al<\/i>. Association between serum uric acid to high density lipoprotein-cholesterol ratio and arterial stiffness in a Japanese population. Medicine (Baltimore) 2023; 102: e34182.","DOI":"10.1097\/MD.0000000000034182"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Harrold LR, Etzel CJ, Gibofsky A, <i>et al<\/i>. 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