{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:04:19Z","timestamp":1780113859126,"version":"3.54.0"},"reference-count":36,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2026,5,30]]},"DOI":"10.1536\/ihj.25-377","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:09:25Z","timestamp":1780092565000},"page":"265-274","source":"Crossref","is-referenced-by-count":0,"title":["TIF1\u03b2 Promotes Myocardial Ischemia-Reperfusion Injury by Stabilizing TRAF6 through Mediating TRAF6 SUMOylation"],"prefix":"10.1536","volume":"67","author":[{"given":"Yue","family":"Nan","sequence":"first","affiliation":[{"name":"First Central Clinical School, Tianjin Medical University"},{"name":"Department of Cardiology, Tianjin Fifth Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Central Clinical School, Tianjin Medical University"},{"name":"Department of Cardiology, Tianjin First Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Fifth Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Fifth Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin First Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bansal M, Mehta A, Balakrishna AM, <i>et al<\/i>. Race, Ethnicity, and Gender Disparities in Acute Myocardial Infarction. Crit Care Clin 2024; 40: 685-707.","DOI":"10.1016\/j.ccc.2024.05.005"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Jung KT, Bapat A, Kim YK, Hucker WJ, Lee K. Therapeutic hypothermia for acute myocardial infarction: a narrative review of evidence from animal and clinical studies. Korean J Anesthesiol 2022; 75: 216-30.","DOI":"10.4097\/kja.22156"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Yang T, Zhang D. Research progress on the effects of novel hypoglycemic drugs in diabetes combined with myocardial ischemia\/reperfusion injury. Ageing Res Rev 2023; 86: 101884.","DOI":"10.1016\/j.arr.2023.101884"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Li S, Li F, Wang Y, <i>et al<\/i>. Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective. Drug Deliv 2024; 31: 2298514.","DOI":"10.1080\/10717544.2023.2298514"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Huang J, Li Z, Huang W, <i>et al<\/i>. Ablation of CCDC8 provides cardioprotection against cardiomyocyte apoptosis via TNF signaling pathway in myocardial ischemia reperfusion injury. Life Sci 2024; 358: 123151.","DOI":"10.1016\/j.lfs.2024.123151"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Zhao X, Wang Z, Wang L, Jiang T, Dong D, Sun M. The PINK1\/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia\/reperfusion injury. Pharmacol Res 2024; 209: 107466.","DOI":"10.1016\/j.phrs.2024.107466"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Dou Y, Shen H, Feng D, <i>et al<\/i>. Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress. J Neurochem 2017; 142: 478-92.","DOI":"10.1111\/jnc.14075"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gu Q, Wang B, Zhao H, Wang W, Wang P, Deng Y. LncRNA promoted inflammatory response in ischemic heart failure through regulation of miR-455-3p\/TRAF6 axis. Inflamm Res 2020; 69: 667-81.","DOI":"10.1007\/s00011-020-01348-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Miyahara T, Koyama H, Miyata T, <i>et al<\/i>. Inflammatory signaling pathway containing TRAF6 contributes to neointimal formation via diverse mechanisms. Cardiovasc Res 2004; 64: 154-64.","DOI":"10.1016\/j.cardiores.2004.06.014"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wang X, Ha T, Zou J, <i>et al<\/i>. MicroRNA-125b protects against myocardial ischaemia\/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6. Cardiovasc Res 2014; 102: 385-95.","DOI":"10.1093\/cvr\/cvu044"},{"key":"11","unstructured":"11. Zhang J, Gao C, Zhang J, Ye F. Circ_0010729 knockdown protects cardiomyocytes against hypoxic dysfunction via miR-370-3p\/TRAF6 axis. Excli J 2020; 19: 1520-32."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Sun Y, Huang J, Song K. BET protein inhibition mitigates acute myocardial infarction damage in rats via the TLR4\/TRAF6\/NF-\u03baB pathway. Exp Ther Med 2015; 10: 2319-24.","DOI":"10.3892\/etm.2015.2789"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Liang YP, Liu Q, Xu GH, <i>et al<\/i>. The lncRNA ROR\/miR-124-3p\/TRAF6 axis regulated the ischaemia reperfusion injury-induced inflammatory response in human cardiac myocytes. J Bioenerg Biomembr 2019; 51: 381-92.","DOI":"10.1007\/s10863-019-09812-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Zhong Q, Xiao X, Qiu Y, <i>et al<\/i>. Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications. MedComm 2023; 4: e261.","DOI":"10.1002\/mco2.261"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hennrich ML, Gavin AC. Quantitative mass spectrometry of posttranslational modifications: keys to confidence. Sci Signal 2015; 8: re5.","DOI":"10.1126\/scisignal.aaa6466"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hotz PW, M\u00fcller S, Mendler L. SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease. Front Mol Biosci 2021; 8: 786136.","DOI":"10.3389\/fmolb.2021.786136"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lascorz J, Codina-Fabra J, Reverter D, Torres-Rosell J. SUMO-SIM interactions: From structure to biological functions. Semin Cell Dev Biol 2022; 132: 193-202.","DOI":"10.1016\/j.semcdb.2021.11.007"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Bish R, Cuevas-Polo N, Cheng Z, <i>et al<\/i>. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Biomolecules 2015; 5: 1441-66.","DOI":"10.3390\/biom5031441"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Zhang XH, Zhao HY, Wang Y, <i>et al<\/i>. Zenglv Fumai Granule protects cardiomyocytes against hypoxia\/reoxygenation-induced apoptosis via inhibiting TRIM28 expression. Mol Med Rep 2021; 23: 171.","DOI":"10.3892\/mmr.2020.11810"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. Hotz PW, Wiesnet M, Tascher G, Braun T, M\u00fcller S, Mendler L. Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury. Molecules 2020; 25: 5571.","DOI":"10.3390\/molecules25235571"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. He H, Liu P, Li P. Dexmedetomidine Ameliorates Cardiac Ischemia\/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK\/SIRT3 Pathway. Drug Des Devel Ther 2023; 17: 3205-18.","DOI":"10.2147\/DDDT.S428024"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Li L, Cao C, Guo H, <i>et al<\/i>. Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome. BMC Complement Med Ther 2025; 25: 9.","DOI":"10.1186\/s12906-025-04747-8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Wang X, Ha T, Liu L, <i>et al<\/i>. Increased expression of microRNA-146a decreases myocardial ischaemia\/reperfusion injury. Cardiovasc Res 2013; 97: 432-42.","DOI":"10.1093\/cvr\/cvs356"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Heusch G. Myocardial ischemia\/reperfusion: Translational pathophysiology of ischemic heart disease. Med 2024; 5: 10-31.","DOI":"10.1016\/j.medj.2023.12.007"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Wang R, Wang M, Zhou J, <i>et al<\/i>. Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia-Reperfusion Injury: Possible Mechanism and Target Analysis. Front Pharmacol 2020; 11: 570867.","DOI":"10.3389\/fphar.2020.570867"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Li Y, Xie H, Liu S, Ruan Z, Wang B. Resveratrol Alleviates Ischemia-Reperfusion-Induced Neuronal Damage by Inhibiting NR3C2-Mediated TRIM28 Expression. J Integr Neurosci 2025; 24: 31375.","DOI":"10.31083\/JIN31375"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Yamamoto M, Gohda J, Akiyama T, Inoue JI. TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-\u03baB activation. Proc Jpn Acad Ser B Phys Biol Sci 2021; 97: 145-60.","DOI":"10.2183\/pjab.97.009"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Abdullah M, Berthiaume JM, Willis MS. Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all. Transl Res 2018; 195: 48-61.","DOI":"10.1016\/j.trsl.2017.10.012"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Cai H, Han Y. Silenced long non-coding RNA RMST ameliorates cardiac dysfunction and inflammatory response in doxorubicin-induced heart failure in C57BL\/6 mice via the modulation of the microRNA-10b-5p\/TRAF6 axis. J Physiol Biochem 2025; 81: 99-110.","DOI":"10.1007\/s13105-024-01056-5"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Meng WT, Zhu J, Wang YC, <i>et al<\/i>. Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-\u03baB signaling pathway after myocardial ischemia-reperfusion injury. J Nanobiotechnology 2024; 22: 382.","DOI":"10.1186\/s12951-024-02631-0"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Ramirez-Correa GA, Martinez-Ferrando MI, Zhang P, Murphy AM. Targeted proteomics of myofilament phosphorylation and other protein posttranslational modifications. Proteomics Clin Appl 2014; 8: 543-53.","DOI":"10.1002\/prca.201400034"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Chen J, Luo Y, Wang S, Zhu H, Li D. Roles and mechanisms of SUMOylation on key proteins in myocardial ischemia\/reperfusion injury. J Mol Cell Cardiol 2019; 134: 154-64.","DOI":"10.1016\/j.yjmcc.2019.07.009"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Sahin U, de Th\u00e9 H, Lallemand-Breitenbach V. Sumoylation in Physiology, Pathology and Therapy. Cells 2022; 11: 814.","DOI":"10.3390\/cells11050814"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Sun W, Wang J, Liu C, <i>et al<\/i>. SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia. Int J Biol Macromol 2024; 268: 131678.","DOI":"10.1016\/j.ijbiomac.2024.131678"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Kang L, Wang X, Wang J, Guo J, Zhang W, Lei R. SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription. Biochim Biophys Acta Gen Subj 2024; 1868: 130500.","DOI":"10.1016\/j.bbagen.2023.130500"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Sumam de Oliveira D, Kronenberger T, Palmisano G, Wrenger C, de Souza EE. Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy. Front Cell Infect Microbiol 2021; 11: 685866.","DOI":"10.3389\/fcimb.2021.685866"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/67\/3\/67_25-377\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:31:24Z","timestamp":1780111884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/67\/3\/67_25-377\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.25-377","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"value":"1349-2365","type":"print"},{"value":"1349-3299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]},"article-number":"25-377"}}