{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T16:10:09Z","timestamp":1746029409864,"version":"3.40.4"},"reference-count":30,"publisher":"International Heart Journal (Japanese Heart Journal)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. Heart J."],"published-print":{"date-parts":[[2013]]},"DOI":"10.1536\/ihj.54.279","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T22:55:45Z","timestamp":1380840945000},"page":"279-284","source":"Crossref","is-referenced-by-count":2,"title":["Rate-Dependent Electrophysiologic Effects of the Class III Antiarrhythmic Drugs Nifekalant, Amiodarone, and Ibutilide on the Atrium in Patients With Persistent Atrial Fibrillation"],"prefix":"10.1536","volume":"54","author":[{"given":"Kazumasa","family":"Sonoda","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimie","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Okumura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kofune","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikitake","family":"Kogawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Mano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Nakai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"437","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Waktare JE, Camm AJ. Atrial fibrillation begets trouble. Heart 1997; 77: 393-4.","DOI":"10.1136\/hrt.77.5.393"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Nattel S. Newer developments in the management of atrial fibrillation. Am Heart J 1995; 130: 1094-106. (Review)","DOI":"10.1016\/0002-8703(95)90214-7"},{"key":"3","unstructured":"3. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N Engl J Med 1989; 321: 406-12."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lazzara R. From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol 1996; 78: 28-33.","DOI":"10.1016\/S0002-9149(96)00450-X"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hohnloser SH, van de Loo A, Baedeker F. Efficacy and proarrhythmic hazards of pharmacologic cardioversion of atrial fibrillation: prospective comparison of sotalol versus quinidine. J Am Coll Cardiol 1995; 26: 852-8.","DOI":"10.1016\/0735-1097(95)00286-5"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wang J, Bourne GW, Wang Z, Villemaire C, Talajic M, Nattel S. Comparative mechanisms of antiarrhythmic drug action in experimental atrial fibrillation. Importance of use-dependent effects on refractoriness. Circulation 1993; 88: 1030-44.","DOI":"10.1161\/01.CIR.88.3.1030"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nattel S, Liu L, St-Georges D. Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties. Cardiovasc Res 1998; 37: 627-35.","DOI":"10.1016\/S0008-6363(97)00252-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Li D, B&eacute;nardeau A, Nattel S. Contrasting efficacy of dofetilide in differing experimental models of atrial fibrillation. Circulation 2000; 102: 104-12.","DOI":"10.1161\/01.CIR.102.1.104"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Morillo CA, Klein GJ, Jones DL, Guiraudon CM. Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation 1995; 91: 1588-95.","DOI":"10.1161\/01.CIR.91.5.1588"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995; 92: 1954-68.","DOI":"10.1161\/01.CIR.92.7.1954"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Nakaya H, Tohse N, Takeda Y, Kanno M. Effects of NS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes. Br J Pharmacol 1993; 109: 157-63.","DOI":"10.1111\/j.1476-5381.1993.tb13546.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Franz MR, Karasik PL, Li C, Moubarak J, Chavez M. Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter. J Am Coll Cardiol 1997; 30: 1785-92.","DOI":"10.1016\/S0735-1097(97)00385-9"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Okumura Y, Watanabe I, Nakai T, <I>et al<\/I>. Recurrence of atrial fibrillation after internal cardioversion of persistent atrial fibrillation: prognostic importance of electrophysiologic parameters. Circ J 2005; 69: 1514-20.","DOI":"10.1253\/circj.69.1514"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Okumura Y, Watanabe I, Ashino S, <I>et al<\/I>. Electrophysiological properties of the atrium after cardioversion of chronic atrial fibrillation: relation to the plasma brain natriuretic peptide level. Int Heart J 2007; 48: 485-96.","DOI":"10.1536\/ihj.48.485"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yue L, Feng J, Gaspo R, Li GR, Wang Z, Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 1997; 81: 512-25.","DOI":"10.1161\/01.RES.81.4.512"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Van Wagoner DR, Pond AL, McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res 1997; 80: 772-81.","DOI":"10.1161\/01.RES.80.6.772"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. van der Velden HMW, van der Zee L, Wijffels MC, <I>et al<\/I>. Atrial fibrillation in the goat induces changes in monophasic action potential and mRNA expression of ion channels involved in repolarization. J Cardiovasc Electrophysiol 2000; 11: 1262-9.","DOI":"10.1046\/j.1540-8167.2000.01262.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Pandozi C, Bianconi L, Villani M, <I>et al<\/I>. Electrophysiological characteristics of the human atria after cardioversion of persistent atrial fibrillation. Circulation 1998; 98: 2860-5.","DOI":"10.1161\/01.CIR.98.25.2860"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kofune T, Watanabe I, Okubo K, <I>et al<\/I>. Effect of IKr blocker nifekalant on atrial action potential duration after successful internal cardioversion of chronic atrial fibrillation. Pacing Clin Electrophysiol 2005; 28: 391-6.","DOI":"10.1111\/j.1540-8159.2005.09531.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Watanabe H, Watanabe I, Nakai T, <I>et al<\/I>. Frequency-dependent electrophysiological effects of flecainide, nifekalant, and d,l-sotalol on the human atrium. Jpn Cir J 2001; 65: 1-6.","DOI":"10.1253\/jcj.65.1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kodama I, Kamiya K, Toyama J. Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent. Am J Cardiol 1999; 84: 20R-28R. (Review)","DOI":"10.1016\/S0002-9149(99)00698-0"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Kodama I, Kamiya K, Toyama J. Cellular electropharmacology of amiodarone. Cardiovasc Res 1997; 35: 13-29. (Review)","DOI":"10.1016\/S0008-6363(97)00114-4"},{"key":"23","unstructured":"23. Okumura Y, Watanabe I, Masaki R, <I>et al<\/I>. Rate-dependent electrophysiologic effects of intravenous administration of amiodarone in human atrium. Prog Med 2001; 21(Suppl 1): 1067-71."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Stambler BS, Wood MA, Ellenbogen KA, Perry KT, Wakefield LK, VanderLugt JT. Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Ibutilide Repeat Dose Study Investigators. Circulation 1996; 94: 1613-21.","DOI":"10.1161\/01.CIR.94.7.1613"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Lee KS. Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward current Na+ in guinea pig ventricular cells. J Pharmacol Exp Ther 1992; 262: 99-108.","DOI":"10.1016\/S0022-3565(25)10779-9"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Yang T, Snyders DJ, Roden DM. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation 1995; 91: 1799-806.","DOI":"10.1161\/01.CIR.91.6.1799"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Oshikawa N, Watanabe I, Masaki R, <I>et al<\/I>. Frequency-dependent electrophysiological effect of ibutilide on human atrium and ventricle. J Interv Card Electrophysiol 2001; 5: 81-7.","DOI":"10.1023\/A:1009866126492"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Duyschaever M, Blaauw Y, Allessie M. Consequences of atrial remodeling for the anti-arrhythmic action of class IC and class III drugs. Cardiovasc Res 2005; 67: 69-76.","DOI":"10.1016\/j.cardiores.2005.02.019"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Burashnikov A, Di Diego JM, Sicouri S, Ferreoro M, Carlsson L, Antzelevitch C. Atrial-selective effects of amiodarone in the management of atrial fibrillation. Heart Rhythm 2008; 5: 1735-42.","DOI":"10.1016\/j.hrthm.2008.09.015"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Tse HF, Lau CP. Electrophysiologic actions of dl-sotalol in patients with persistent atrial fibrillation. J Am Coll Cardiol 2002; 40: 2150-5.","DOI":"10.1016\/S0735-1097(02)02592-5"}],"container-title":["International Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/54\/5\/54_279\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T15:28:36Z","timestamp":1746026916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/54\/5\/54_279\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1536\/ihj.54.279","relation":{},"ISSN":["1349-2365","1349-3299"],"issn-type":[{"type":"print","value":"1349-2365"},{"type":"electronic","value":"1349-3299"}],"subject":[],"published":{"date-parts":[[2013]]}}}