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Haverkate F, Thompson SG, Pyke SDM, Gallimore JR, Pepys MB, for the European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Production of C-reactive protein and risk of coronary events in stable and unstable angina. Lancet 1997; 349: 462-6.","key":"23","DOI":"10.1016\/S0140-6736(96)07591-5"},{"doi-asserted-by":"crossref","unstructured":"26. Kuller LH, Tracy RP, Shaten J, Meilahn EN, for the MRFIT Research Group. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Am J Epidemiol 1996; 144: 537-47.","key":"24","DOI":"10.1093\/oxfordjournals.aje.a008963"},{"doi-asserted-by":"crossref","unstructured":"27. Ridker PM, Cushman M, Stamper MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-9.","key":"25","DOI":"10.1056\/NEJM199704033361401"},{"doi-asserted-by":"publisher","unstructured":"28. 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