{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:55:39Z","timestamp":1789786539017,"version":"4.0.1"},"reference-count":34,"publisher":"Japanese Association for Laboratory Animal Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2015]]},"DOI":"10.1538\/expanim.15-0001","type":"journal-article","created":{"date-parts":[[2015,4,26]],"date-time":"2015-04-26T22:05:08Z","timestamp":1430085908000},"page":"305-312","source":"Crossref","is-referenced-by-count":12,"title":["Role of large MAF transcription factors in the mouse endocrine pancreas"],"prefix":"10.1538","volume":"64","author":[{"given":"Ahmed M.","family":"ABDELLATIF","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"},{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Mansoura University, Elgomhouria Street, Mansoura, Dakahlyia 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohito","family":"OGATA","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"KUDO","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulibaikelamu","family":"XIAFUKAITI","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsin","family":"CHANG","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi C.","family":"KATOH","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah E.","family":"EL-MORSY","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Mansoura University, Elgomhouria Street, Mansoura, Dakahlyia 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"OISHI","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"},{"name":"Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"TAKAHASHI","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"},{"name":"Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan"},{"name":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"439","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Artner I., Blanchi B., Raum J.C., Guo M., Kaneko T., Cordes S., Sieweke M., and Stein R. 2007. MafB is required for islet beta cell maturation. <i>Proc. Natl. Acad. Sci. USA<\/i> 104: 3853\u20133858.","DOI":"10.1073\/pnas.0700013104"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Artner I., Hang Y., Mazur M., Yamamoto T., Guo M., Lindner J., Magnuson M.A., and Stein R. 2010. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. <i>Diabetes<\/i> 59: 2530\u20132539.","DOI":"10.2337\/db10-0190"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Aziz A., Vanhille L., Mohideen P., Kelly L.M., Otto C., Bakri Y., Mossadegh N., Sarrazin S., and Sieweke M.H. 2006. Development of macrophages with altered actin organization in the absence of MafB. <i>Mol. Cell. Biol.<\/i> 26: 6808\u20136818.","DOI":"10.1128\/MCB.00245-06"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Benitez C.M., Goodyer W.R., and Kim S.K. 2012. Deconstructing pancreas developmental biology. <i>Cold Spring Harb. Perspect. Biol.<\/i> 4: 4.","DOI":"10.1101\/cshperspect.a012401"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Collombat P., Mansouri A., Hecksher-Sorensen J., Serup P., Krull J., Gradwohl G., and Gruss P. 2003. Opposing actions of Arx and Pax4 in endocrine pancreas development. <i>Genes Dev.<\/i> 17: 2591\u20132603.","DOI":"10.1101\/gad.269003"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dor Y. and Glaser B. 2013. \u03b2-cell dedifferentiation and type 2 diabetes. <i>N. Engl. J. Med.<\/i> 368: 572\u2013573.","DOI":"10.1056\/NEJMcibr1214034"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Eto K., Nishimura W., Oishi H., Udagawa H., Kawaguchi M., Hiramoto M., Fujiwara T., Takahashi S., and Yasuda K. 2014. MafA is required for postnatal proliferation of pancreatic \u03b2-cells. <i>PLoS ONE<\/i> 9: e104184.","DOI":"10.1371\/journal.pone.0104184"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Friedman J.R. and Kaestner K.H. 2006. The Foxa family of transcription factors in development and metabolism. <i>Cell. Mol. Life Sci.<\/i> 63: 2317\u20132328.","DOI":"10.1007\/s00018-006-6095-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gosmain Y., Avril I., Mamin A., and Philippe J. 2007. Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. <i>J. Biol. Chem.<\/i> 282: 35024\u201335034.","DOI":"10.1074\/jbc.M702795200"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Gradwohl G., Dierich A., LeMeur M., and Guillemot F. 2000. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. <i>Proc. Natl. Acad. Sci. USA<\/i> 97: 1607\u20131611.","DOI":"10.1073\/pnas.97.4.1607"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hang Y., Yamamoto T., Benninger R.K., Brissova M., Guo M., Bush W., Piston D.W., Powers A.C., Magnuson M., Thurmond D.C., and Stein R. 2014. The MafA transcription factor becomes essential to islet \u03b2-cells soon after birth. <i>Diabetes<\/i> 63: 1994\u20132005.","DOI":"10.2337\/db13-1001"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hay C.W. and Docherty K. 2006. Comparative analysis of insulin gene promoters: implications for diabetes research. <i>Diabetes<\/i> 55: 3201\u20133213.","DOI":"10.2337\/db06-0788"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. im Walde S.S., Dohle C., Schott-Ohly P., and Gleichmann H. 2002. Molecular target structures in alloxan-induced diabetes in mice. <i>Life Sci.<\/i> 71: 1681\u20131694.","DOI":"10.1016\/S0024-3205(02)01918-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kataoka K. 2007. Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes. <i>J. Biochem.<\/i> 141: 775\u2013781.","DOI":"10.1093\/jb\/mvm105"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kawauchi S., Takahashi S., Nakajima O., Ogino H., Morita M., Nishizawa M., Yasuda K., and Yamamoto M. 1999. Regulation of lens fiber cell differentiation by transcription factor c-Maf. <i>J. Biol. Chem.<\/i> 274: 19254\u201319260.","DOI":"10.1074\/jbc.274.27.19254"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kroon E., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H., Richardson M., Smart N.G., Cunningham J., Agulnick A.D., D\u2019Amour K.A., Carpenter M.K., and Baetge E.E. 2008. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. <i>Nat. Biotechnol.<\/i> 26: 443\u2013452.","DOI":"10.1038\/nbt1393"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kushner J.A., Ciemerych M.A., Sicinska E., Wartschow L.M., Teta M., Long S.Y., Sicinski P., and White M.F. 2005. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. <i>Mol. Cell. Biol.<\/i> 25: 3752\u20133762.","DOI":"10.1128\/MCB.25.9.3752-3762.2005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Lacy P.E. and Kostianovsky M. 1967. Method for the isolation of intact islets of Langerhans from the rat pancreas. <i>Diabetes<\/i> 16: 35\u201339.","DOI":"10.2337\/diab.16.1.35"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Matsuoka T.A., Zhao L., Artner I., Jarrett H.W., Friedman D., Means A., and Stein R. 2003. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. <i>Mol. Cell. Biol.<\/i> 23: 6049\u20136062.","DOI":"10.1128\/MCB.23.17.6049-6062.2003"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Moriguchi T., Hamada M., Morito N., Terunuma T., Hasegawa K., Zhang C., Yokomizo T., Esaki R., Kuroda E., Yoh K., Kudo T., Nagata M., Greaves D.R., Engel J.D., Yamamoto M., and Takahashi S. 2006. MafB is essential for renal development and F4\/80 expression in macrophages. <i>Mol. Cell. Biol.<\/i> 26: 5715\u20135727.","DOI":"10.1128\/MCB.00001-06"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nagasaki H., Katsumata T., Oishi H., Tai P.H., Sekiguchi Y., Koshida R., Jung Y., Kudo T., and Takahashi S. 2014. Generation of insulin-producing cells from the mouse liver using \u03b2 cell-related gene transfer including Mafa and Mafb. <i>PLoS ONE<\/i> 9: e113022.","DOI":"10.1371\/journal.pone.0113022"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Nishimura W., Kondo T., Salameh T., El Khattabi I., Dodge R., Bonner-Weir S., and Sharma A. 2006. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. <i>Dev. Biol.<\/i> 293: 526\u2013539.","DOI":"10.1016\/j.ydbio.2006.02.028"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nishimura W., Rowan S., Salameh T., Maas R.L., Bonner-Weir S., Sell S.M., and Sharma A. 2008. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. <i>Dev. Biol.<\/i> 314: 443\u2013456.","DOI":"10.1016\/j.ydbio.2007.12.009"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Nishimura W., Takahashi S., and Yasuda K. 2015. MafA is critical for maintenance of the mature beta cell phenotype in mice. <i>Diabetologia<\/i> 58: 566\u2013574.","DOI":"10.1007\/s00125-014-3464-9"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Nishizawa M., Kataoka K., Goto N., Fujiwara K.T., and Kawai S. 1989. v-maf, a viral oncogene that encodes a \u201cleucine zipper\u201d motif. <i>Proc. Natl. Acad. Sci. USA<\/i> 86: 7711\u20137715.","DOI":"10.1073\/pnas.86.20.7711"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Ohneda K., Ee H., and German M. 2000. Regulation of insulin gene transcription. <i>Semin. Cell Dev. Biol.<\/i> 11: 227\u2013233.","DOI":"10.1006\/scdb.2000.0171"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Orci L. and Unger R.H. 1975. Functional subdivision of islets of Langerhans and possible role of D cells. <i>Lancet<\/i> 2: 1243\u20131244.","DOI":"10.1016\/S0140-6736(75)92078-4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Slack J.M. 1995. Developmental biology of the pancreas. <i>Development<\/i> 121: 1569\u20131580.","DOI":"10.1242\/dev.121.6.1569"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Spijker H.S., Ravelli R.B., Mommaas-Kienhuis A.M., van Apeldoorn A.A., Engelse M.A., Zaldumbide A., Bonner-Weir S., Rabelink T.J., Hoeben R.C., Clevers H., Mummery C.L., Carlotti F., and de Koning E.J. 2013. Conversion of mature human \u03b2-cells into glucagon-producing \u03b1-cells. <i>Diabetes<\/i> 62: 2471\u20132480.","DOI":"10.2337\/db12-1001"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Talchai C., Xuan S., Lin H.V., Sussel L., and Accili D. 2012. Pancreatic \u03b2 cell dedifferentiation as a mechanism of diabetic \u03b2 cell failure. <i>Cell<\/i> 150: 1223\u20131234.","DOI":"10.1016\/j.cell.2012.07.029"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wang Z., York N.W., Nichols C.G., and Remedi M.S. 2014. Pancreatic \u03b2 cell dedifferentiation in diabetes and redifferentiation following insulin therapy. <i>Cell Metab.<\/i> 19: 872\u2013882.","DOI":"10.1016\/j.cmet.2014.03.010"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Weir G.C., Aguayo-Mazzucato C., and Bonner-Weir S. 2013. \u03b2-cell dedifferentiation in diabetes is important, but what is it?<i>Islets<\/i> 5: 233\u2013237.","DOI":"10.4161\/isl.27494"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. ZeRuth G.T., Takeda Y., and Jetten A.M. 2013. The Kr\u00fcppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. <i>Mol. Endocrinol.<\/i> 27: 1692\u20131705.","DOI":"10.1210\/me.2013-1117"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Zhang C., Moriguchi T., Kajihara M., Esaki R., Harada A., Shimohata H., Oishi H., Hamada M., Morito N., Hasegawa K., Kudo T., Engel J.D., Yamamoto M., and Takahashi S. 2005. MafA is a key regulator of glucose-stimulated insulin secretion. <i>Mol. Cell. Biol.<\/i> 25: 4969\u20134976.","DOI":"10.1128\/MCB.25.12.4969-4976.2005"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/64\/3\/64_15-0001\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T03:36:50Z","timestamp":1651808210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/64\/3\/64_15-0001\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.15-0001","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}