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Avsaroglu H., van der Sar A.S., van Lith H.A., van Zutphen L.F., and Hellebrekers L.J. 2007. Differences in response to anaesthetics and analgesics between inbred rat strains. <i>Lab. Anim.<\/i> 41: 337\u2013344.","DOI":"10.1258\/002367707781282811"},{"key":"2","unstructured":"2. Baker N.J., Schofield J.C., Caswell M.D., and McLellan A.D. 2011. Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice. <i>J. Am. Assoc. Lab. Anim. Sci.<\/i> 50: 916\u2013920."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bellini L., Banzato T., Contiero B., and Zotti A. 2014. Evaluation of three medetomidine-based protocols for chemical restraint and sedation for non-painful procedures in companion rats (<i>Rattus norvegicus<\/i>). <i>Vet. J.<\/i> 200: 456\u2013458.","DOI":"10.1016\/j.tvjl.2014.03.024"},{"key":"4","unstructured":"4. Boyd R.L., Halderman L.W., Harris J.O., and Mangos J.A. 1982. Strain differences in pulmonary function of laboratory rats. <i>Lab. Anim. Sci.<\/i> 32: 42\u201343."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ciccone G.K. and Holdcroft A. 1999. Drugs and sex differences: a review of drugs relating to anaesthesia. <i>Br. J. Anaesth.<\/i> 82: 255\u2013265.","DOI":"10.1093\/bja\/82.2.255"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fender C., Fujinaga M., and Maze M. 2000. Strain differences in the antinociceptive effect of nitrous oxide on the tail flick test in rats. <i>Anesth. Analg.<\/i> 90: 195\u2013199.","DOI":"10.1097\/00000539-200001000-00039"},{"key":"7","unstructured":"7. Flecknell P.A. 2009. Chapter 2, Anesthesia. p.24 In: Laboratory Animal Anaesthesia. 3rd ed. ELSEVIER, London."},{"key":"8","unstructured":"8. Flecknell P.A. 2009. Chapter 3, Analgesic management. p.83\u201387 In: Laboratory Animal Anaesthesia. 3rd ed. ELSEVIER, London."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gordon C.J. and Watkinson W.P. 1995. Strain differences in the laboratory rat: impact on the autonomic, behavioral, and biochemical response to cholinesterase inhibition. <i>J. Toxicol. Environ. Health<\/i> 45: 59\u201373.","DOI":"10.1080\/15287399509531980"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Itamoto K., Hikasa Y., Sakonjyu I., Itoh H., Kakuta T., and Takase K. 2000. Anaesthetic and cardiopulmonary effects of balanced anaesthesia with medetomidine-midazolam and butorphanol in dogs. <i>J. Vet. Med. A Physiol. Pathol. Clin. Med.<\/i> 47: 411\u2013420.","DOI":"10.1046\/j.1439-0442.2000.00302.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Jang H.S., Choi H.S., Lee S.H., Jang K.H., and Lee M.G. 2009. Evaluation of the anaesthetic effects of medetomidine and ketamine in rats and their reversal with atipamezole. <i>Vet. Anaesth. Analg.<\/i> 36: 319\u2013327.","DOI":"10.1111\/j.1467-2995.2009.00463.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kalema-Zikusoka G., Horne W.A., Levine J., and Loomis M.R. 2003. Comparison of the cardiorespiratory effects of medetomidine-butorphanol-ketamine and medetomidine-butorphanol-midazolam in patas monkeys (Erythrocebus patas). <i>J. Zoo Wildl. Med.<\/i> 34: 47\u201352.","DOI":"10.1638\/1042-7260(2003)34[0047:COTCEO]2.0.CO;2"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kawai S., Takagi Y., Kaneko S., and Kurosawa T. 2011. Effect of three types of mixed anesthetic agents alternate to ketamine in mice. <i>Exp. Anim.<\/i> 60: 481\u2013487.","DOI":"10.1538\/expanim.60.481"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kirihara Y., Takechi M., Kurosaki K., Kobayashi Y., and Kurosawa T. 2013. Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in two strains of mice. <i>Exp. Anim.<\/i> 62: 173\u2013180.","DOI":"10.1538\/expanim.62.173"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kirihara Y., Takechi M., Kurosaki K., Kobayashi Y., Saito Y., and Takeuchi T. 2015. Anesthetic effects of a three-drugs mixture\u2014comparison of administrative routes and antagonistic effects of atipamezole in mice. <i>Exp. Anim.<\/i> 64: 39\u201347.","DOI":"10.1538\/expanim.14-0039"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Konno K., Shiotani Y., Itano N., Ogawa T., Hatakeyama M., Shioya K., and Kasai N. 2014. Visible, safe and certain endotracheal intubation using endoscope system and inhalation anesthesia for rats. <i>J. Vet. Med. Sci.<\/i> 76: 1375\u20131381.","DOI":"10.1292\/jvms.14-0146"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ochi T., Nishiura I., Tatsumi M., Hirano Y., Yahagi K., Sakurai Y., Matsuyama-Fujiwara K., Sudo Y., Nishina N., and Koyama H. 2014. Anesthetic effect of a combination of medetomidine-midazolam-butorphanol in cynomolgus monkeys (Macaca fascicularis). <i>J. Vet. Med. Sci.<\/i> 76: 917\u2013921.","DOI":"10.1292\/jvms.13-0589"},{"key":"18","unstructured":"18. Ohno M., Hirose H., and Sugano S. 1987. Alteration in heart rate and conduction time during the growing process of rats, mice and guinea pigs. (Japanese). <i>Adv. Anim. Cardiol.<\/i> 20: 24\u201332."},{"key":"19","unstructured":"19. Pang H., Kawai S., Shioya K., Katahira K., Yabuuci K., Tajima M., and Kurosawa T. 2010. Short anesthesia with a combination of three injectable anesthetic in rat. <i>Exp. Anim.<\/i> 59: 370."},{"key":"20","unstructured":"20. Pypendop B. and Verstegen J. 1999. Cardiorespiratory effects of a combination of medetomidine, midazolam, and butorphanol in dogs. <i>Am. J. Vet. Res.<\/i> 60: 1148\u20131154."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Siller-Matula J.M. and Jilma B. 2008. Strain differences in toxic effects of long-lasting isoflurane anaesthesia between Wistar rats and Sprague Dawley rats. <i>Food Chem. 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