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Red cell metabolism: a manual of biochemical methods. Academic Press, London."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bradley P.P., Priebat D.A., Christensen R.D., and Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. <i>J. Invest. Dermatol.<\/i> 78: 206\u2013209.","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chen C., Tian L., Zhang M., Sun Q., Zhang X., Li X., Cao X., Liu Q., Li X., and Hao L. 2013. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. <i>Dig. Dis. Sci.<\/i> 58: 3134\u20133143.","DOI":"10.1007\/s10620-013-2826-3"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. de Ara\u00fajo A.A., Borba P.B., de Souza F.H., Nogueira A.C., Saldanha T.S., Ara\u00fajo T.E., da Silva A.I., and de Ara\u00fajo J\u00fanior R.F. 2015. In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity. <i>Biol. Pharm. Bull.<\/i> 38: 746\u2013752.","DOI":"10.1248\/bpb.b14-00847"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Demiryilmaz I., Turan M.I., Kisaoglu A., Gulapoglu M., Yilmaz I., and Suleyman H. 2014. Protective effect of nimesulide against hepatic ischemia\/reperfusion injury in rats: effects on oxidant\/antioxidants, DNA mutation and COX-1\/COX-2 levels. <i>Pharmacol. Rep.<\/i> 66: 647\u2013652.","DOI":"10.1016\/j.pharep.2014.02.015"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gulgun M., Erdem O., Oztas E., Kesik V., Balamtekin N., Vurucu S., Kul M., Kismet E., and Koseoglu V. 2010. Proanthocyanidin prevents methotrexate-induced intestinal damage and oxidative stress. <i>Exp. Toxicol. Pathol.<\/i> 62: 109\u2013115.","DOI":"10.1016\/j.etp.2009.02.120"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hoekstra M., van Ede A.E., Haagsma C.J., van de Laar M.A., Huizinga T.W., Kruijsen M.W., and Laan R.F. 2003. Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. <i>Ann. Rheum. Dis.<\/i> 62: 423\u2013426.","DOI":"10.1136\/ard.62.5.423"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Huang C., Hsu P., Hung Y., Liao Y., Liu C., Hour C., Kao M., Tsay G.J., Hung H., and Liu G.Y. 2005. Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production. <i>Apoptosis<\/i> 10: 895\u2013907.","DOI":"10.1007\/s10495-005-2947-z"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13. Kolli V.K., Abraham P., Isaac B., and Kasthuri N. 2013. Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats. <i>Dig. Dis. Sci.<\/i> 58: 959\u2013969.","DOI":"10.1007\/s10620-012-2437-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"14. Kolli V.K., Kanakasabapathy I., Faith M., Ramamoorthy H., Isaac B., Natarajan K., and Abraham P. 2013. A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation. <i>Cancer Chemother. Pharmacol.<\/i> 71: 1209\u20131218.","DOI":"10.1007\/s00280-013-2115-z"},{"key":"14","doi-asserted-by":"crossref","unstructured":"15. Lalla R.V. and Peterson D.E. 2006. Treatment of mucositis, including new medications. <i>Cancer J.<\/i> 12: 348\u2013354.","DOI":"10.1097\/00130404-200609000-00004"},{"key":"15","unstructured":"16. Maffei Facino R., Carini M., Aldini G., Saibene L., and Morelli R. 1995. Differential inhibition of superoxide, hydroxyl and peroxyl radicals by nimesulide and its main metabolite 4-hydroxynimesulide. <i>Arzneimittelforschung<\/i> 45: 1102\u20131109."},{"key":"16","doi-asserted-by":"crossref","unstructured":"17. Miyazono Y., Gao F., and Horie T. 2004. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. <i>Scand. J. Gastroenterol.<\/i> 39: 1119\u20131127.","DOI":"10.1080\/00365520410003605"},{"key":"17","doi-asserted-by":"crossref","unstructured":"18. Moghadam A.R., Mohajeri D., Namvaran-Abbas-Abad A., Manafi H., Shahi D., and Mazani M. 2013. Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress. <i>Chin. J. Nat. Med.<\/i> 11: 477\u2013483.","DOI":"10.1016\/S1875-5364(13)60087-4"},{"key":"18","doi-asserted-by":"crossref","unstructured":"19. Niscola P., Romani C., Cupelli L., Scaramucci L., Tendas A., Dentamaro T., Amadori S., and de Fabritiis P. 2007. Mucositis in patients with hematologic malignancies: an overview. <i>Haematologica<\/i> 92: 222\u2013231.","DOI":"10.3324\/haematol.10232"},{"key":"19","doi-asserted-by":"crossref","unstructured":"20. Oktar B.K., Cakir B., Mutlu N., Celikel C., and Alican I. 2002. Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage. <i>Burns<\/i> 28: 209\u2013214.","DOI":"10.1016\/S0305-4179(02)00004-9"},{"key":"20","doi-asserted-by":"crossref","unstructured":"21. Phillips D.C., Woollard K.J., and Griffiths H.R. 2003. The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. <i>Br. J. Pharmacol.<\/i> 138: 501\u2013511.","DOI":"10.1038\/sj.bjp.0705054"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22. Singh V.P., Patil C.S., Jain N.K., Singh A., and Kulkarni S.K. 2003. Effect of nimesulide on acetic acid- and leukotriene-induced inflammatory bowel disease in rats. <i>Prostaglandins Other Lipid Mediat.<\/i> 71: 163\u2013175.","DOI":"10.1016\/S1098-8823(03)00038-8"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23. Soares P.M., Lopes L.O., Mota J.M., Belarmino-Filho J.N., Ribeiro R.A., and Souza M.H. 2011. Methotrexate-induced intestinal mucositis delays gastric emptying and gastrointestinal transit of liquids in awake rats. <i>Arq. Gastroenterol.<\/i> 48: 80\u201385.","DOI":"10.1590\/S0004-28032011000100016"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24. Sonis S.T., Elting L.S., Keefe D., Peterson D.E., Schubert M., Hauer-Jensen M., Bekele B.N., Raber-Durlacher J., Donnelly J.P., Rubenstein E.B., Mucositis Study Section of the Multinational Association for Supportive Care in Cancer, andInternational Society for Oral Oncology 2004. 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