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Boorman G.A., Rafferty C.N., Ward J.M., and Sills R.C. 2000. Leukemia and lymphoma incidence in rodents exposed to low-frequency magnetic fields. <i>Radiat. Res.<\/i> 153: 627\u2013636.","DOI":"10.1667\/0033-7587(2000)153[0627:LALIIR]2.0.CO;2"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bosma G.C., Fried M., Custer R.P., Carroll A., Gibson D.M., and Bosma M.J. 1988. Evidence of functional lymphocytes in some (leaky) <i>scid<\/i> mice. <i>J. Exp. Med.<\/i> 167: 1016\u20131033.","DOI":"10.1084\/jem.167.3.1016"},{"key":"3","unstructured":"3. Coggin J.H. Jr., Rohrer S.D., Leinbach E.D., Hester R.B., Liu P.I., and Heath L.S. 1988. Radiation-induced lymphoblastic lymphomas\/leukemias and sarcomas of mice express conserved, immunogenic 44-kilodalton oncofetal antigen. <i>Am. J. Pathol.<\/i> 130: 136\u2013146."},{"key":"4","unstructured":"4. Custer R.P., Bosma G.C., and Bosma M.J. 1985. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. <i>Am. J. Pathol.<\/i> 120: 464\u2013477."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Dixon D., Alison R., Bach U., Colman K., Foley G.L., Harleman J.H., Haworth R., Herbert R., Heuser A., Long G., Mirsky M., Regan K., Van Esch E., Westwood F.R., Vidal J., and Yoshida M. 2014. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system. <i>J. Toxicol. Pathol.<\/i> 27 (3\u20134 Suppl): 1S-107S.","DOI":"10.1293\/tox.27.1S"},{"key":"6","unstructured":"6. Gold L.S., Manley N.B., Slone T.H., and Ward J.M. 2001. Compendium of chemical carcinogens by target organ: results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys. <i>Toxicol. Pathol.<\/i> 29: 639\u2013652."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Greaves P., Chouinard L., Ernst H., Mecklenburg L., Pruimboom-Brees I.M., Rinke M., Rittinghausen S., Thibault S., Von Erichsen J., and Yoshida T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium. <i>J. Toxicol. Pathol.<\/i> 26:(Suppl): 1S\u201326S.","DOI":"10.1293\/tox.26.1S"},{"key":"8","unstructured":"8. Haley P., Perry R., Ennulat D., Frame S., Johnson C., Lapointe J.M., Nyska A., Snyder P., Walker D., Walter G., STP Immunotoxicology Working Group. 2005. STP position paper: best practice guideline for the routine pathology evaluation of the immune system. <i>Toxicol. Pathol.<\/i> 33: 404\u2013407, discussion 408."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Hiramatsu H., Nishikomori R., Heike T., Ito M., Kobayashi K., Katamura K., and Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD\/SCID\/gammacnull mice model. <i>Blood<\/i> 102: 873\u2013880.","DOI":"10.1182\/blood-2002-09-2755"},{"key":"10","unstructured":"10. Huang P., Westmoreland S.V., Jain R.K., and Fukumura D. 2011. Spontaneous nonthymic tumors in SCID mice. <i>Comp. Med.<\/i> 61: 227\u2013234."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ito M., Hiramatsu H., Kobayashi K., Suzue K., Kawahata M., Hioki K., Ueyama Y., Koyanagi Y., Sugamura K., Tsuji K., Heike T., and Nakahata T. 2002. NOD\/SCID\/\u03b3(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. <i>Blood<\/i> 100: 3175\u20133182.","DOI":"10.1182\/blood-2001-12-0207"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ito R., Takahashi T., Katano I., Kawai K., Kamisako T., Ogura T., Ida-Tanaka M., Suemizu H., Nunomura S., Ra C., Mori A., Aiso S., and Ito M. 2013. Establishment of a human allergy model using human IL-3\/GM-CSF-transgenic NOG mice. <i>J. Immunol.<\/i> 191: 2890\u20132899.","DOI":"10.4049\/jimmunol.1203543"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Katano I., Ito R., Eto T., Aiso S., and Ito M. 2011. Immunodeficient NOD-<i>scid<\/i> IL-2R\u03b3(<sup>null<\/sup>) mice do not display T and B cell leakiness. <i>Exp. Anim.<\/i> 60: 181\u2013186.","DOI":"10.1538\/expanim.60.181"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Katano I., Takahashi T., Ito R., Kamisako T., Mizusawa T., Ka Y., Ogura T., Suemizu H., Kawakami Y., and Ito M. 2015. Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse. <i>J. Immunol.<\/i> 194: 3513\u20133525.","DOI":"10.4049\/jimmunol.1401323"},{"key":"15","unstructured":"15. Kato C., Fujii E., Chen Y.J., Endaya B.B., Matsubara K., Suzuki M., Ohnishi Y., and Tamaoki N. 2009. Spontaneous thymic lymphomas in the non-obese diabetic\/Shi-<i>scid<\/i>, IL-2R \u03b3 (null) mouse. <i>Lab. Anim.<\/i> 43: 402\u2013404."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kanemura H., Go M.J., Shikamura M., Nishishita N., Sakai N., Kamao H., Mandai M., Morinaga C., Takahashi M., and Kawamata S. 2014. Tumorigenicity studies of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration. <i>PLoS One<\/i> 9: e85336.","DOI":"10.1371\/journal.pone.0085336"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kawamata S., Kanemura H., Sakai N., Takahashi M., and Go M.J. 2015. Design of a tumorigenicity test for induced pluripotent stem cell (iPSC)-derived cell products. <i>J. Clin. Med.<\/i> 4: 159\u2013171.","DOI":"10.3390\/jcm4010159"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kozak C.A. 2014. Origins of the endogenous and infectious laboratory mouse gammaretroviruses. <i>Viruses<\/i> 7: 1\u201326.","DOI":"10.3390\/v7010001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Mancini G., Carbonara A.O., and Heremans J.F. 1965. Immunochemical quantitation of antigens by single radial immunodiffusion. <i>Immunochemistry<\/i> 2: 235\u2013254.","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Maronpot R.R. 2006. A monograph on histomorphologic evaluation of lymphoid organs. <i>Toxicol. Pathol.<\/i> 34: 407\u2013408.","DOI":"10.1080\/01926230600978466"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Oka S., Mori N., Matsuyama S., Takamori Y., and Kubo K. 2000. Presence of B220 within thymocytes and its expression on the cell surface during apoptosis. <i>Immunology<\/i> 100: 417\u2013423.","DOI":"10.1046\/j.1365-2567.2000.00063.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Prochazka M., Gaskins H.R., Shultz L.D., and Leiter E.H. 1992. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. <i>Proc. Natl. Acad. Sci. USA<\/i> 89: 3290\u20133294.","DOI":"10.1073\/pnas.89.8.3290"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Renne R., Brix A., Harkema J., Herbert R., Kittel B., Lewis D., March T., Nagano K., Pino M., Rittinghausen S., Rosenbruch M., Tellier P., and Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. <i>Toxicol. Pathol.<\/i> 37:(Suppl): 5S\u201373S.","DOI":"10.1177\/0192623309353423"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Renno T., Attinger A., Rimoldi D., Hahne M., Tschopp J., and MacDonald H.R. 1998. Expression of B220 on activated T cell blasts precedes apoptosis. <i>Eur. J. Immunol.<\/i> 28: 540\u2013547.","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<540::AID-IMMU540>3.0.CO;2-Y"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Renno T., Hahne M., Tschopp J., and MacDonald H.R. 1996. Peripheral T cells undergoing superantigen-induced apoptosis <i>in vivo<\/i> express B220 and upregulate Fas and Fas ligand. <i>J. Exp. Med.<\/i> 183: 431\u2013437.","DOI":"10.1084\/jem.183.2.431"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Rudmann D., Cardiff R., Chouinard L., Goodman D., K\u00fcttler K., Marxfeld H., Molinolo A., Treumann S., Yoshizawa K., INHAND Mammary, Zymbal\u2019s, Preputial, and Clitoral Gland Organ Working Group. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal\u2019s, preputial, and clitoral glands. <i>Toxicol. Pathol.<\/i> 40:(Suppl): 7S\u201339S.","DOI":"10.1177\/0192623312454242"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Serreze D.V., Leiter E.H., Hanson M.S., Christianson S.W., Shultz L.D., Hesselton R.M., and Greiner D.L. 1995. <i>Emv30<\/i><sup>null<\/sup> NOD-<i>scid<\/i> mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells. <i>Diabetes<\/i> 44: 1392\u20131398.","DOI":"10.2337\/diabetes.44.12.1392"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Soulard V., Bosson-Vanga H., Lorthiois A., Roucher C., Franetich J.F., Zanghi G., Bordessoulles M., Tefit M., Thellier M., Morosan S., Le Naour G., Capron F., Suemizu H., Snounou G., Moreno-Sabater A., and Mazier D. 2015. Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice. <i>Nat. Commun.<\/i> 6: 7690.","DOI":"10.1038\/ncomms8690"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Shultz L.D., Lyons B.L., Burzenski L.M., Gott B., Chen X., Chaleff S., Kotb M., Gillies S.D., King M., Mangada J., Greiner D.L., and Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD\/LtSz-<i>scid IL2R \u03b3 <sup>null<\/sup><\/i> mice engrafted with mobilized human hemopoietic stem cells. <i>J. Immunol.<\/i> 174: 6477\u20136489.","DOI":"10.4049\/jimmunol.174.10.6477"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Taddesse-Heath L., Chattopadhyay S.K., Dillehay D.L., Lander M.R., Nagashfar Z., Morse H.C. 3rd., and Hartley J.W. 2000. Lymphomas and high-level expression of murine leukemia viruses in CFW mice. <i>J. Virol.<\/i> 74: 6832\u20136837.","DOI":"10.1128\/JVI.74.15.6832-6837.2000"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wakabayashi Y., Inoue J., Takahashi Y., Matsuki A., Kosugi-Okano H., Shinbo T., Mishima Y., Niwa O., and Kominami R. 2003. Homozygous deletions and point mutations of the <i>Rit1\/Bcl11b<\/i> gene in \u03b3-ray induced mouse thymic lymphomas. <i>Biochem. Biophys. Res. Commun.<\/i> 301: 598\u2013603.","DOI":"10.1016\/S0006-291X(02)03069-3"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Watanabe S., Ohta S., Yajima M., Terashima K., Ito M., Mugishima H., Fujiwara S., Shimizu K., Honda M., Shimizu N., and Yamamoto N. 2007. Humanized NOD\/SCID\/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. <i>J. Virol.<\/i> 81: 13259\u201313264.","DOI":"10.1128\/JVI.01353-07"},{"key":"33","unstructured":"33. Yahata T., Ando K., Nakamura Y., Ueyama Y., Shimamura K., Tamaoki N., Kato S., and Hotta T. 2002. Functional human T lymphocyte development from cord blood CD34<sup>+<\/sup> cells in nonobese diabetic\/Shi-<i>scid<\/i>, IL-2 receptor \u03b3 null mice. <i>J. Immunol.<\/i> 169: 204\u2013209."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Young G.R., Eksmond U., Salcedo R., Alexopoulou L., Stoye J.P., and Kassiotis G. 2012. Resurrection of endogenous retroviruses in antibody-deficient mice. <i>Nature<\/i> 491: 774\u2013778.","DOI":"10.1038\/nature11599"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Yu P., L\u00fcbben W., Slomka H., Gebler J., Konert M., Cai C., Neubrandt L., Prazeres da Costa O., Paul S., Dehnert S., D\u00f6hne K., Thanisch M., Storsberg S., Wiegand L., Kaufmann A., Nain M., Quintanilla-Martinez L., Bettio S., Schnierle B., Kolesnikova L., Becker S., Schnare M., and Bauer S. 2012. Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. <i>Immunity<\/i> 37: 867\u2013879.","DOI":"10.1016\/j.immuni.2012.07.018"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/66\/4\/66_17-0034\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T12:11:00Z","timestamp":1569672660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/66\/4\/66_17-0034\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.17-0034","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}