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Amrein R. and Hetzel W. 1990. Pharmacology of Dormicum (midazolam) and Anexate (flumazenil). <i>Acta Anaesthesiol. Scand. Suppl.<\/i> 92: 6\u201315, discussion 47."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Aranake A., Mashour G.A., and Avidan M.S. 2013. Minimum alveolar concentration: ongoing relevance and clinical utility. <i>Anaesthesia<\/i> 68: 512\u2013522.","DOI":"10.1111\/anae.12168"},{"key":"3","unstructured":"3. Buitrago S., Martin T.E., Tetens-Woodring J., Belicha-Villanueva A., and Wilding G.E. 2008. Safety and efficacy of various combinations of injectable anesthetics in BALB\/c mice. <i>J. Am. Assoc. Lab. Anim. Sci.<\/i> 47: 11\u201317."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. de Wolff M.H., Leather H.A., and Wouters P.F. 1999. Effects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats. <i>Br. J. Anaesth.<\/i> 83: 780\u2013783.","DOI":"10.1093\/bja\/83.5.780"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Diven K. 2003. Inhalation anesthetics in rodents. <i>Lab Anim. (NY)<\/i> 32: 44\u201347.","DOI":"10.1038\/laban0303-44"},{"key":"6","unstructured":"6. Dodelet-Devillers A., Zullian C., Vachon P., and Beaudry F. 2016. Assessment of stability of ketamine-xylazine preparations with or without acepromazine using high performance liquid chromatography-mass spectrometry. <i>Can. J. Vet. Res.<\/i> 80: 86\u201389."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Fish R.E. 2008. Anesthesia and Analgesia in Laboratory Animals. 2nd ed. <i>ACLAM<\/i>, Academic press, London.","DOI":"10.1016\/B978-012373898-1.00014-1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hobbhahn J. and Funk W. 1996. [Sevoflurane in pediatric anesthesia]. <i>Anaesthesist<\/i> 45:(Suppl 1): S22\u2013S27. 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Murakami M., Niwa H., Kushikata T., Watanabe H., Hirota K., Ono K., and Ohba T. 2014. Inhalation anesthesia is preferable for recording rat cardiac function using an electrocardiogram. <i>Biol. Pharm. Bull.<\/i> 37: 834\u2013839.","DOI":"10.1248\/bpb.b14-00012"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Robinson B.J., Uhrich T.D., and Ebert T.J. 1999. A review of recovery from sevoflurane anaesthesia: comparisons with isoflurane and propofol including meta-analysis. <i>Acta Anaesthesiol. Scand.<\/i> 43: 185\u2013190.","DOI":"10.1034\/j.1399-6576.1999.430211.x"},{"key":"14","unstructured":"14. Salonen J.S. 1989. Pharmacokinetics of medetomidine. <i>Acta Vet. Scand. Suppl.<\/i> 85: 49\u201354."},{"key":"15","unstructured":"15. Shekarforoush S., Fatahi Z., and Safari F. 2016. The effects of pentobarbital, ketamine-pentobarbital and ketamine-xylazine anesthesia in a rat myocardial ischemic reperfusion injury model. <i>Lab. Anim.<\/i> 50: 179\u2013184."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Smith I., Nathanson M., and White P.F. 1996. Sevoflurane--a long-awaited volatile anaesthetic. <i>Br. J. Anaesth.<\/i> 76: 435\u2013445.","DOI":"10.1093\/bja\/76.3.435"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sonner J.M., Gong D., and Eger E.I. 2nd 2000. Naturally occurring variability in anesthetic potency among inbred mouse strains. <i>Anesth. Analg.<\/i> 91: 720\u2013726.","DOI":"10.1213\/00000539-200009000-00042"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Steffey E.P. 2002. Recent advances in inhalation anesthesia. <i>Vet. Clin. North Am. Equine Pract.<\/i> 18: 159\u2013168.","DOI":"10.1016\/S0749-0739(01)00007-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tsukamoto A., Konishi Y., Kawakami T., Koibuchi C., Sato R., Kanai E., and Inomata T. 2017. 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