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Boskey A.L. and Coleman R. 2010. Aging and bone. <i>J. Dent. Res.<\/i> 89: 1333\u20131348.","DOI":"10.1177\/0022034510377791"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bratic A. and Larsson N.G. 2013. The role of mitochondria in aging. <i>J. Clin. Invest.<\/i> 123: 951\u2013957.","DOI":"10.1172\/JCI64125"},{"key":"3","unstructured":"3. Fox R.G., Magness S., Kujoth G.C., Prolla T.A., and Maeda N. 2012. Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i> 302: G914\u2013G924."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Fraser W.D. 2009. Hyperparathyroidism. <i>Lancet<\/i> 374: 145\u2013158.","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Freeman D., Lesche R., Kertesz N., Wang S., Li G., Gao J., Groszer M., Martinez-Diaz H., Rozengurt N., Thomas G., Liu X., and Wu H. 2006. Genetic background controls tumor development in PTEN-deficient mice. <i>Cancer Res.<\/i> 66: 6492\u20136496.","DOI":"10.1158\/0008-5472.CAN-05-4143"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hashizume O., Yamanashi H., Taketo M.M., Nakada K., and Hayashi J.I. 2015. A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA. <i>PLoS One<\/i> 10: e0118561.","DOI":"10.1371\/journal.pone.0118561"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hashizume O., Ohnishi S., Mito T., Shimizu A., Ishikawa K., Nakada K., Soda M., Mano H., Togayachi S., Miyoshi H., Okita K., and Hayashi J.I. 2015. Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. <i>Sci. Rep.<\/i> 5: 10434.","DOI":"10.1038\/srep10434"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hashizume O., Shimizu A., Yokota M., Sugiyama A., Nakada K., Miyoshi H., Itami M., Ohira M., Nagase H., Takenaga K., and Hayashi J.I. 2012. Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development. <i>Proc. Natl. Acad. Sci. USA<\/i> 109: 10528\u201310533.","DOI":"10.1073\/pnas.1202367109"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Hayashi J.I., Ohta S., Kagawa Y., Kondo H., Kaneda H., Yonekawa H., Takai D., and Miyabayashi S. 1994. Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects. <i>J. Biol. Chem.<\/i> 269: 6878\u20136883.","DOI":"10.1016\/S0021-9258(17)37457-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hayashi J.I., Hashizume O., Ishikawa K., and Shimizu A. 2016. Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging. <i>Curr. Opin. Genet. Dev.<\/i> 38: 63\u201367.","DOI":"10.1016\/j.gde.2016.03.004"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Inoue K., Nakada K., Ogura A., Isobe K., Goto Y., Nonaka I., and Hayashi J.I. 2000. Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes. <i>Nat. Genet.<\/i> 26: 176\u2013181.","DOI":"10.1038\/82826"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Isobe K., Ito S., Hosaka H., Iwamura Y., Kondo H., Kagawa Y., and Hayashi J.I. 1998. Nuclear-recessive mutations of factors involved in mitochondrial translation are responsible for age-related respiration deficiency of human skin fibroblasts. <i>J. Biol. Chem.<\/i> 273: 4601\u20134606.","DOI":"10.1074\/jbc.273.8.4601"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Jacobs H.T. 2003. The mitochondrial theory of aging: dead or alive? <i>Aging Cell<\/i> 2: 11\u201317.","DOI":"10.1046\/j.1474-9728.2003.00032.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Khrapko K. and Vijg J. 2009. Mitochondrial DNA mutations and aging: devils in the details? <i>Trends Genet.<\/i> 25: 91\u201398.","DOI":"10.1016\/j.tig.2008.11.007"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Krupke D.M., Begley D.A., Sundberg J.P., Bult C.J., and Eppig J.T. 2008. The Mouse Tumor Biology database. <i>Nat. Rev. Cancer<\/i> 8: 459\u2013465.","DOI":"10.1038\/nrc2390"},{"key":"16","unstructured":"16. Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., Hofer T., Seo A.Y., Sullivan R., Jobling W.A., Morrow J.D., Van Remmen H., Sedivy J.M., Yamasoba T., Tanokura M., Weindruch R., Leeuwenburgh C., and Prolla T.A. 2005. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. <i>Science<\/i> 309: 481\u2013484."},{"key":"17","unstructured":"17. Mito T., Ishizaki H., Suzuki M., Morishima H., Ota A., Ishikawa K., Nakada K., Maeno A., Shiroishi T., and Hayashi J.I. 2015. Transmitochondrial mito-mice\u0394 and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders. <i>Biochem. Biophys. Res. Commun.<\/i> 456: 933\u2013937."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Mito T., Kikkawa Y., Shimizu A., Hashizume O., Katada S., Imanishi H., Ota A., Kato Y., Nakada K., and Hayashi J.I. 2013. Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development. <i>PLoS One<\/i> 8: e55789.","DOI":"10.1371\/journal.pone.0055789"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Nakada K., Inoue K., Ono T., Isobe K., Ogura A., Goto Y.I., Nonaka I., and Hayashi J.I. 2001. Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. <i>Nat. Med.<\/i> 7: 934\u2013940.","DOI":"10.1038\/90976"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Roghani T., Zavieh M.K., Manshadi F.D., King N., and Katzman W. 2017. Age-related hyperkyphosis: update of its potential causes and clinical impacts-narrative review. <i>Aging Clin. Exp. Res.<\/i> 29: 567\u2013577.","DOI":"10.1007\/s40520-016-0617-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sato A., Kono T., Nakada K., Ishikawa K., Inoue S., Yonekawa H., and Hayashi J.I. 2005. Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation. <i>Proc. Natl. Acad. Sci. USA<\/i> 102: 16765\u201316770.","DOI":"10.1073\/pnas.0506197102"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Takai D., Inoue K., Shisa H., Kagawa Y., and Hayashi J.I. 1995. Age-associated changes of mitochondrial translation and respiratory function in mouse brain. <i>Biochem. Biophys. Res. Commun.<\/i> 217: 668\u2013674.","DOI":"10.1006\/bbrc.1995.2826"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Taylor R.W. and Turnbull D.M. 2005. Mitochondrial DNA mutations in human disease. <i>Nat. Rev. Genet.<\/i> 6: 389\u2013402.","DOI":"10.1038\/nrg1606"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly-Y M., Gidl\u00f6f S., Oldfors A., Wibom R., T\u00f6rnell J., Jacobs H.T., and Larsson N.G. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. <i>Nature<\/i> 429: 417\u2013423.","DOI":"10.1038\/nature02517"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Wallace D.C. 1999. 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