{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:48:33Z","timestamp":1772142513845,"version":"3.50.1"},"reference-count":35,"publisher":"Japanese Association for Laboratory Animal Science","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2020]]},"DOI":"10.1538\/expanim.19-0042","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T22:04:11Z","timestamp":1574114651000},"page":"168-177","source":"Crossref","is-referenced-by-count":13,"title":["mRNA and P-element-induced wimpy testis-interacting RNA profile in          chemical-induced oral squamous cell carcinoma mice model"],"prefix":"10.1538","volume":"69","author":[{"given":"Lihong","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingtong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Diseases, National              Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory              Health, the First Affiliated Hospital of Guangzhou Medical University, 195 Dongfengxi              Road, Guangzhou, Guangdong 510230, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janak L.","family":"Pathak","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingtao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"},{"name":"Center of Emphasis in Infectious Diseases, Department              of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University              Health Sciences Center El Paso, El Paso, Texas 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huade","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, South              China University of Technology, 381 Wushan Road, Guangzhou, Guangdong 510006,              China"},{"name":"National Engineering Research Center for Tissue              Restoration and Reconstruction, South China University of Technology, 381 Wushan Road,              Guangzhou, Guangdong 510006, China"},{"name":"Key Laboratory of Biomedical Engineering of Guangdong              Province, and Innovation Center for Tissue Restoration and Reconstruction, South China              University of Technology, 381 Wushan Road, Guangzhou, Guangdong 510006,              China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexiong","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Medicine, Guangzhou Institute of              Oral Disease, Stomatology Hospital of Guangzhou Medical University, 31 Huangsha Road,              Guangzhou, Guangdong 510140, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"439","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Aravin              A., Gaidatzis              D., Pfeffer              S.,                Lagos-Quintana              M., Landgraf              P., Iovino              N., Morris              P.,                Brownstein              M.J.,                Kuramochi-Miyagawa              S., Nakano              T., Chien              M., Russo              J.J., Ju              J., Sheridan              R., Sander              C., Zavolan              M. and Tuschl              T.          2006. A novel class of small RNAs bind to MILI protein in            mouse testes. <i>Nature<\/i>          442: 203\u2013207.","DOI":"10.1038\/nature04916"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bisetto              S.,                Whitaker-Menezes              D., Wilski              N.A., Tuluc              M., Curry              J., Zhan              T., Snyder              C.M.,                Martinez-Outschoorn              U.E. and                Philp              N.J.          2018. Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have            Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell            Cancer. <i>Front. Oncol.<\/i>          8: 324.","DOI":"10.3389\/fonc.2018.00324"},{"key":"3","unstructured":"3. Cao              W., Zhang              Z.Y., Xu              Q., Sun              Q., Yan              M., Zhang              J., Zhang              P., Han              Z.G. and Chen              W.T.          2010. Epigenetic silencing of MAL, a putative tumor suppressor            gene, can contribute to human epithelium cell carcinoma.              <i>Mol. Cancer<\/i>          9: 296."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chen              Y.F., Yang              C.C., Kao              S.Y., Liu              C.J., Lin              S.C. and                Chang              K.W.          2016. MicroRNA-211 Enhances the Oncogenicity of            Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant            Activity. <i>Cancer Res.<\/i>          76: 4872\u20134886.","DOI":"10.1158\/0008-5472.CAN-15-1664"},{"key":"5","unstructured":"5. Cheng              J., Deng              H., Xiao              B., Zhou              H., Zhou              F., Shen              Z. and Guo              J.          2012. piR-823, a novel non-coding small RNA, demonstrates in            vitro and in vivo tumor suppressive activity in human gastric cancer            cells. <i>Cancer Lett.<\/i>          315: 12\u201317."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chu              T.H., Yang              C.C., Liu              C.J., Lui              M.T., Lin              S.C. and                Chang              K.W.          2013. miR-211 promotes the progression of head and neck            carcinomas by targeting TGF\u03b2RII. <i>Cancer            Lett.<\/i>          337: 115\u2013124.","DOI":"10.1016\/j.canlet.2013.05.032"},{"key":"7","doi-asserted-by":"crossref","unstructured":"8. Darda              L., Hakami              F., Morgan              R., Murdoch              C., Lambert              D.W. and                Hunter              K.D.          2015. The role of HOXB9 and miR-196a in head and neck squamous            cell carcinoma. <i>PLoS One<\/i>          10: e0122285.","DOI":"10.1371\/journal.pone.0122285"},{"key":"8","doi-asserted-by":"crossref","unstructured":"9. Das              B., Roy              J., Jain              N. and                Mallick              B.          2019. Tumor suppressive activity of PIWI-interacting RNA in            human fibrosarcoma mediated through repression of RRM2.              <i>Mol. Carcinog.<\/i>          58: 344\u2013357.","DOI":"10.1002\/mc.22932"},{"key":"9","doi-asserted-by":"crossref","unstructured":"10. Ding              J., Yang              C. and Yang              S.          2018. LINC00511 interacts with miR-765 and modulates tongue            squamous cell carcinoma progression by targeting LAMC2.              <i>J. Oral Pathol. Med.<\/i>          47: 468\u2013476.","DOI":"10.1111\/jop.12677"},{"key":"10","unstructured":"11. Duan              J., Chen              L., Gao              H., Zhen              T., Li              H., Liang              J., Zhang              F., Shi              H. and Han              A.          2018. GALNT6 suppresses progression of colorectal            cancer. <i>Am. J. Cancer Res.<\/i>          8: 2419\u20132435."},{"key":"11","doi-asserted-by":"crossref","unstructured":"12. Hasegawa              H., Kusumi              Y., Asakawa              T., Maeda              M., Oinuma              T., Furusaka              T., Oshima              T. and Esumi              M.          2017. Expression of von Hippel-Lindau tumor suppressor protein            (pVHL) characteristic of tongue cancer and proliferative lesions in tongue            epithelium. <i>BMC Cancer<\/i>          17: 381.","DOI":"10.1186\/s12885-017-3364-8"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13. Hirakata              S., and Siomi              M.C.          2016. piRNA biogenesis in the germline: From transcription of            piRNA genomic sources to piRNA maturation. <i>Biochim.              Biophys. Acta<\/i>          1859: 82\u201392.","DOI":"10.1016\/j.bbagrm.2015.09.002"},{"key":"13","doi-asserted-by":"crossref","unstructured":"14. Huang              S.H., and                O\u2019Sullivan              B. Overview of the 8th Edition          TNM Classification for Head and Neck Cancer. <i>Curr. Treat. Options. Oncol.<\/i>          2017, 18:40.","DOI":"10.1007\/s11864-017-0484-y"},{"key":"14","doi-asserted-by":"crossref","unstructured":"15. Iwasaki              Y.W., Siomi              M.C. and                Siomi              H.          2015. PIWI-Interacting RNA: Its Biogenesis and            Functions. <i>Annu. Rev. Biochem.<\/i>          84: 405\u2013433.","DOI":"10.1146\/annurev-biochem-060614-034258"},{"key":"15","doi-asserted-by":"crossref","unstructured":"16. Jacobs              D.I., Qin              Q., Fu              A., Chen              Z., Zhou              J. and Zhu              Y.          2018. piRNA-8041 is downregulated in human glioblastoma and            suppresses tumor growth <i>in vitro<\/i> and <i>in            vivo<\/i>. <i>Oncotarget<\/i>          9: 37616\u201337626.","DOI":"10.18632\/oncotarget.26331"},{"key":"16","doi-asserted-by":"crossref","unstructured":"17. Jia              Y., Gao              Y., Li              J., Chang              Z., Yan              J. and Qin              Y.          2019. Prognostic implications of MYBL2 in resected Chinese            gastric adenocarcinoma patients. <i>OncoTargets              Ther.<\/i>          12: 1129\u20131135.","DOI":"10.2147\/OTT.S188820"},{"key":"17","doi-asserted-by":"crossref","unstructured":"18. Kanojia              D., and                Vaidya              M.M.          2006. 4-nitroquinoline-1-oxide induced experimental oral            carcinogenesis. <i>Oral Oncol.<\/i>          42: 655\u2013667.","DOI":"10.1016\/j.oraloncology.2005.10.013"},{"key":"18","doi-asserted-by":"crossref","unstructured":"19. Leivonen              S.K., Ala-Aho              R., Koli              K., Gr\u00e9nman              R., Peltonen              J. and K\u00e4h\u00e4ri              V.M.          2006. Activation of Smad signaling enhances collagenase-3            (MMP-13) expression and invasion of head and neck squamous carcinoma            cells. <i>Oncogene<\/i>          25: 2588\u20132600.","DOI":"10.1038\/sj.onc.1209291"},{"key":"19","doi-asserted-by":"crossref","unstructured":"20. Lim              S.L., Qu              Z.P.,                Kortschak              R.D.,                Lawrence              D.M.,                Geoghegan              J., Hempfling              A.L.,                Bergmann              M., Goodnow              C.C., Ormandy              C.J., Wong              L., Mann              J., Scott              H.S., Jamsai              D., Adelson              D.L. and                O\u2019Bryan              M.K.          2015. HENMT1 and piRNA Stability Are Required for Adult Male            Germ Cell Transposon Repression and to Define the Spermatogenic Program in the            Mouse. <i>PLoS Genet.<\/i>          11: e1005620.","DOI":"10.1371\/journal.pgen.1005620"},{"key":"20","unstructured":"21. Matse              J.H., Bharos              W.K., Veerman              E.C.I.,                Bloemena              E. and                Bolscher              J.G.M.          2017. Mucoepidermoid carcinoma-associated expression of            MUC5AC, MUC5B and mucin-type carbohydrate antigen sialyl-Tn in the parotid            gland. <i>Arch. Oral Biol.<\/i>          82: 121\u2013126."},{"key":"21","doi-asserted-by":"crossref","unstructured":"22. Nguyen              C.T., Okamura              T., Morita              K.I.,                Yamaguchi              S., Harada              H., Miki              Y., Izumo              T., Kayamori              K., Yamaguchi              A. and                Sakamoto              K.          2017. LAMC2 is a predictive marker for the malignant            progression of leukoplakia. <i>J. Oral Pathol.              Med.<\/i>          46: 223\u2013231.","DOI":"10.1111\/jop.12485"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23. Pal              S.K., Noguchi              S., Yamamoto              G., Yamada              A., Isobe              T., Hayashi              S., Tanaka              J., Tanaka              Y., Kamijo              R., Yamane              G.Y. and                Tachikawa              T.          2012. Expression of myelin and lymphocyte protein (MAL) in            oral carcinogenesis. <i>Med. Mol.            Morphol.<\/i>          45: 222\u2013228.","DOI":"10.1007\/s00795-011-0563-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24. Peng              L., Song              L., Liu              C., Lv              X., Li              X., Jie              J., Zhao              D. and Li              D.          2016. piR-55490 inhibits the growth of lung carcinoma by            suppressing mTOR signaling. <i>Tumour            Biol.<\/i>          37: 2749\u20132756.","DOI":"10.1007\/s13277-015-4056-0"},{"key":"24","doi-asserted-by":"crossref","unstructured":"25. Tang              X.H., Urvalek              A.M.,                Osei-Sarfo              K., Zhang              T.,                Scognamiglio              T. and Gudas              L.J.          2015. Gene expression profiling signatures for the diagnosis            and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq            technology. <i>Oncotarget<\/i>          6: 24424\u201324435.","DOI":"10.18632\/oncotarget.4420"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26. Tseng              S.H., Yang              C.C., Yu              E.H., Chang              C., Lee              Y.S., Liu              C.J., Chang              K.W. and Lin              S.C.          2015. K14-EGFP-miR-31 transgenic mice have high susceptibility            to chemical-induced squamous cell tumorigenesis that is associating with Ku80            repression. <i>Int. J. Cancer<\/i>          136: 1263\u20131275.","DOI":"10.1002\/ijc.29106"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27. Vella              S., Gallo              A., Lo Nigro              A., Galvagno              D., Raffa              G.M., Pilato              M. and                Conaldi              P.G.          2016. PIWI-interacting RNA (piRNA) signatures in human cardiac            progenitor cells. <i>Int. J. Biochem. Cell            Biol.<\/i>          76: 1\u201311.","DOI":"10.1016\/j.biocel.2016.04.012"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28. Vychytilova-Faltejskova              P.,                Stitkovcova              K., Radova              L., Sachlova              M., Kosarova              Z., Slaba              K., Kala              Z., Svoboda              M., Kiss              I., Vyzula              R., Cho              W.C. and                Slaby              O.          2018. Circulating PIWI-Interacting RNAs piR-5937 and piR-28876            Are Promising Diagnostic Biomarkers of Colon Cancer.              <i>Cancer Epidemiol. Biomarkers Prev.<\/i>          27: 1019\u20131028.","DOI":"10.1158\/1055-9965.EPI-18-0318"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29. Weng              W., Li              H. and Goel              A.          2019. Piwi-interacting RNAs (piRNAs) and cancer: Emerging            biological concepts and potential clinical implications.              <i>Biochim. Biophys. Acta Rev. Cancer<\/i>          1871: 160\u2013169.","DOI":"10.1016\/j.bbcan.2018.12.005"},{"key":"29","unstructured":"30. Weng              W., Liu              N., Toiyama              Y., Kusunoki              M., Nagasaka              T., Fujiwara              T., Wei              Q., Qin              H., Lin              H., Ma              Y. and Goel              A.          2018. Novel evidence for a PIWI-interacting RNA (piRNA) as an            oncogenic mediator of disease progression, and a potential prognostic biomarker in            colorectal cancer. <i>Mol. Cancer<\/i>          17: 16."},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Wu              J., Qin              W., Wang              Y., Sadik              A., Liu              J., Wang              Y., Song              P., Wang              X., Sun              K., Zeng              J. and Wang              L.          2018. SPDEF is overexpressed in gastric cancer and triggers            cell proliferation by forming a positive regulation loop with FoxM1.              <i>J. Cell. Biochem.<\/i>          119: 9042\u20139054.","DOI":"10.1002\/jcb.27161"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. Xiao              J., Lu              X., Chen              X., Zou              Y., Liu              A., Li              W., He              B., He              S. and Chen              Q.          2017. Eight potential biomarkers for distinguishing between            lung adenocarcinoma and squamous cell carcinoma.              <i>Oncotarget<\/i>          8: 71759\u201371771.","DOI":"10.18632\/oncotarget.17606"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33. Yu              T., Wu              Y., Helman              J.I., Wen              Y., Wang              C. and Li              L.          2011. CXCR4 promotes oral squamous cell carcinoma migration            and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling            pathway. <i>Mol. Cancer Res.<\/i>          9: 161\u2013172.","DOI":"10.1158\/1541-7786.MCR-10-0386"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34. Zhang              H.X., Liu              O.S., Deng              C., He              Y., Feng              Y.Q., Ma              J.A., Hu              C.H. and Tang              Z.G.          2018. Genome-wide gene expression profiling of tongue squamous            cell carcinoma by RNA-seq. <i>Clin. Oral            Investig.<\/i>          22: 209\u2013216.","DOI":"10.1007\/s00784-017-2101-7"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35. Zhao              C., Tolkach              Y., Schmidt              D., Toma              M., Muders              M.H.,                Kristiansen              G., M\u00fcller              S.C. and                Ellinger              J.          2019. Mitochondrial PIWI-interacting RNAs are novel biomarkers            for clear cell renal cell carcinoma. <i>World J.              Urol.<\/i>          37: 1639\u20131647.","DOI":"10.1007\/s00345-018-2575-1"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36. Zheng              Z., Luan              X., Zha              J., Li              Z., Wu              L., Yan              Y., Wang              H., Hou              D., Huang              L., Huang              F., Zheng              H., Ge              L. and Guan              H.          2017. TNF-\u03b1 inhibits the migration of oral squamous cancer            cells mediated by miR-765-EMP3-p66Shc axis. <i>Cell.              Signal.<\/i>          34: 102\u2013109.","DOI":"10.1016\/j.cellsig.2017.03.009"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/69\/2\/69_19-0042\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T03:20:27Z","timestamp":1587784827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/69\/2\/69_19-0042\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.19-0042","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}