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Aiyer              R., Mehta              N., Gungor              S. and Gulati              A.          2018. A systematic review of NMDA receptor antagonists for            treatment of neuropathic pain in clinical practice.              <i>Clin. J. Pain<\/i>          34: 450\u2013467.","DOI":"10.1097\/AJP.0000000000000547"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Akimitsu              T., Kurisu              K., Hanaya              R., Iida              K., Kiura              Y., Arita              K.,                Matsubayashi              H., Ishihara              K., Kitada              K., Serikawa              T. and Sasa              M.          2000. Epileptic seizures induced by              <i>N<\/i>-acetyl-<sub>L<\/sub>-aspartate in rats: <i>in vivo<\/i> and              <i>in vitro<\/i> studies. <i>Brain            Res.<\/i>          861: 143\u2013150.","DOI":"10.1016\/S0006-8993(00)02028-X"},{"key":"3","unstructured":"3. Benito-Le\u00f3n              J. and Louis              E.D.          2006. Essential tremor: emerging views of a common            disorder. <i>Nat. Clin. Pract. Neurol.<\/i>          2: 666\u2013678, quiz 2p, 691."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Biel              M.,                Wahl-Schott              C.,                Michalakis              S. and Zong              X.          2009. Hyperpolarization-activated cation channels: from genes            to function. <i>Physiol. Rev.<\/i>          89: 847\u2013885.","DOI":"10.1152\/physrev.00029.2008"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Chen              L.W., Tse              Y.C., Li              C., Guan              Z.L., Lai              C.H., Yung              K.K.L., Shum              D.K.Y. and                Chan              Y.S.          2006. Differential expression of NMDA and AMPA\/KA receptor            subunits in the inferior olive of postnatal rats. <i>Brain              Res.<\/i>          1067: 103\u2013114.","DOI":"10.1016\/j.brainres.2005.10.054"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dang              Y.H., Ma              X.C., Zhang              J.C., Ren              Q., Wu              J., Gao              C.G. and                Hashimoto              K.          2014. Targeting of NMDA receptors in the treatment of major            depression. <i>Curr. Pharm. Des.<\/i>          20: 5151\u20135159.","DOI":"10.2174\/1381612819666140110120435"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Furukawa              H., Singh              S.K.,                Mancusso              R. and Gouaux              E.          2005. Subunit arrangement and function in NMDA            receptors. <i>Nature<\/i>          438: 185\u2013192.","DOI":"10.1038\/nature04089"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Jim\u00e9nez-Jim\u00e9nez              F.J.,                Alonso-Navarro              H.,                Garc\u00eda-Mart\u00edn              E.,                Lorenzo-Betancor              O., Pastor              P. and                Ag\u00fandez              J.A.G.          2013. Update on genetics of essential tremor.              <i>Acta Neurol. Scand.<\/i>          128: 359\u2013371.","DOI":"10.1111\/ane.12148"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Llin\u00e1s              R. and Yarom              Y.          1986. Oscillatory properties of guinea-pig inferior olivary            neurones and their pharmacological modulation: an <i>in vitro<\/i>            study. <i>J. Physiol.<\/i>          376: 163\u2013182.","DOI":"10.1113\/jphysiol.1986.sp016147"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Louis              E.D.          2001. Etiology of essential tremor: should we be searching for            environmental causes? <i>Mov. Disord.<\/i>          16: 822\u2013829.","DOI":"10.1002\/mds.1183"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Mikics              E., Toth              M., Biro              L., Bruzsik              B., Nagy              B. and Haller              J.          2017. The role of GluN2B-containing NMDA receptors in short-            and long-term fear recall. <i>Physiol.            Behav.<\/i>          177: 44\u201348.","DOI":"10.1016\/j.physbeh.2017.04.005"},{"key":"12","unstructured":"12. Ngomba              R.T.,                Biagioni              F., Casciato              S., Willems-van                Bree              E., Battaglia              G., Bruno              V., Nicoletti              F. and van                Luijtelaar              E.L.J.M.          2005. The preferential mGlu2\/3 receptor antagonist, LY341495,            reduces the frequency of spike-wave discharges in the WAG\/Rij rat model of absence            epilepsy. <i>Neuropharmacology<\/i>          49:(Suppl 1):            89\u2013103."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Nishitani              A., Kunisawa              N., Sugimura              T., Sato              K., Yoshida              Y., Suzuki              T., Sakuma              T., Yamamoto              T., Asano              M., Saito              Y., Ohno              Y. and                Kuramoto              T.          2019. Loss of <i>HCN1<\/i> subunits causes absence            epilepsy in rats. <i>Brain Res.<\/i>          1706: 209\u2013217.","DOI":"10.1016\/j.brainres.2018.11.004"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Nishitani              A., Tanaka              M., Shimizu              S., Kunisawa              N., Yokoe              M., Yoshida              Y., Suzuki              T., Sakuma              T., Yamamoto              T., Kuwamura              M., Takenaka              S., Ohno              Y. and                Kuramoto              T.          2016. Involvement of aspartoacylase in tremor expression in            rats. <i>Exp. Anim.<\/i>          65: 293\u2013301.","DOI":"10.1538\/expanim.16-0007"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nishitani              A., Yoshihara              T., Tanaka              M., Kuwamura              M., Asano              M., Tsubota              Y. and                Kuramoto              T.          2020. Muscle weakness and impaired motor coordination in            hyperpolarization-activated cyclic nucleotide-gated potassium channel 1-deficient            rats. <i>Exp. Anim.<\/i>          69: 11\u201317.","DOI":"10.1538\/expanim.19-0067"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ohno              Y., Shimizu              S., Tatara              A., Imaoku              T., Ishii              T., Sasa              M., Serikawa              T. and                Kuramoto              T.          2015. <i>Hcn1<\/i> is a tremorgenic genetic component            in a rat model of essential tremor. <i>PLoS            One<\/i>          10: e0123529.","DOI":"10.1371\/journal.pone.0123529"},{"key":"17","unstructured":"17. Olivares              D., Deshpande              V.K., Shi              Y., Lahiri              D.K., Greig              N.H., Rogers              J.T. and                Huang              X.          2012. N-methyl D-aspartate (NMDA) receptor antagonists and            memantine treatment for Alzheimer\u2019s disease, vascular dementia and Parkinson\u2019s            disease. <i>Curr. Alzheimer Res.<\/i>          9: 746\u2013758."},{"key":"18","unstructured":"18. Palmer              G.C.,                Stagnitto              M.L., Ray              R.K., Knowles              M.A., Harvey              R. and Garske              G.E.          1993. Anticonvulsant properties of calcium channel blockers in            mice: N-methyl-D-,L-aspartate- and Bay K 8644-induced convulsions are potently blocked            by the dihydropyridines. <i>Epilepsia<\/i>          34: 372\u2013380."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Park              Y.G., Park              H.Y., Lee              C.J., Choi              S., Jo              S., Choi              H., Kim              Y.H., Shin              H.S., Llinas              R.R. and Kim              D.          2010. Ca<sub>V<\/sub>3.1 is a tremor rhythm pacemaker in the            inferior olive. <i>Proc. Natl. Acad. Sci.            USA<\/i>          107: 10731\u201310736.","DOI":"10.1073\/pnas.1002995107"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Paterson              N.E.,                Malekiani              S.A., Foreman              M.M., Olivier              B. and                Hanania              T.          2009. Pharmacological characterization of harmaline-induced            tremor activity in mice. <i>Eur. J.            Pharmacol.<\/i>          616: 73\u201380.","DOI":"10.1016\/j.ejphar.2009.05.031"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Placantonakis              D. and Welsh              J.          2001. Two distinct oscillatory states determined by the NMDA            receptor in rat inferior olive. <i>J.            Physiol.<\/i>          534: 123\u2013140.","DOI":"10.1111\/j.1469-7793.2001.t01-1-00123.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Rubin              Y., LaPlaca              M.C., Smith              D.H.,                Thibault              L.E. and                Lenkinski              R.E.          1995. The effect of <i>N<\/i>-acetylaspartate on the            intracellular free calcium concentration in NTera2-neurons.              <i>Neurosci. Lett.<\/i>          198: 209\u2013212.","DOI":"10.1016\/0304-3940(95)12014-U"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Sekiguchi              M., Okamoto              K. and Sakai              Y.          1989. Low-concentration            <i>N<\/i>-acetylaspartylglutamate suppresses the climbing fiber response of            Purkinje cells in guinea pig cerebellar slices and the responses to excitatory amino            acids of <i>Xenopus laevis<\/i> oocytes injected with cerebellar            mRNA. <i>Brain Res.<\/i>          482: 87\u201396.","DOI":"10.1016\/0006-8993(89)90545-3"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Serikawa              T., Mashimo              T., Takizawa              A., Okajima              R., Maedomari              N., Kumafuji              K., Tagami              F., Neoda              Y., Otsuki              M., Nakanishi              S., Yamasaki              K., Voigt              B. and                Kuramoto              T.          2009. National BioResource Project-Rat and related            activities. <i>Exp. Anim.<\/i>          58: 333\u2013341.","DOI":"10.1538\/expanim.58.333"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Szczurowska              E. and Mare\u0161              P.          2015. Different action of a specific NR2B\/NMDA antagonist Ro            25-6981 on cortical evoked potentials and epileptic afterdischarges in immature            rats. <i>Brain Res. Bull.<\/i>          111: 1\u20138.","DOI":"10.1016\/j.brainresbull.2014.11.001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Welsh              J.P.          1998. Systemic harmaline blocks associative and motor learning            by the actions of the inferior olive. <i>Eur. J.              Neurosci.<\/i>          10: 3307\u20133320.","DOI":"10.1046\/j.1460-9568.1998.00334.x"},{"key":"27","unstructured":"27. Wenzel              A., Fritschy              J.M., Mohler              H. and Benke              D.          1997. NMDA receptor heterogeneity during postnatal development            of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit            proteins. <i>J. Neurochem.<\/i>          68: 469\u2013478."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Wroblewska              B.,                Wroblewski              J.T.,                Pshenichkin              S., Surin              A., Sullivan              S.E. and                Neale              J.H.          1997. <i>N<\/i>-acetylaspartylglutamate selectively            activates mGluR3 receptors in transfected cells. <i>J.              Neurochem.<\/i>          69: 174\u2013181.","DOI":"10.1046\/j.1471-4159.1997.69010174.x"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/69\/4\/69_20-0025\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T03:12:10Z","timestamp":1605323530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/69\/4\/69_20-0025\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.20-0025","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}