{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:41:40Z","timestamp":1790757700814,"version":"4.1.0"},"reference-count":66,"publisher":"Japanese Association for Laboratory Animal Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2021]]},"DOI":"10.1538\/expanim.21-0027","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T22:06:28Z","timestamp":1616450788000},"page":"264-271","source":"Crossref","is-referenced-by-count":25,"title":["Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases"],"prefix":"10.1538","volume":"70","author":[{"given":"Satoru","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, Laboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"439","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S. v-maf, a viral oncogene that encodes a \u201cleucine zipper\u201d motif. Proc Natl Acad Sci USA.  1989;  86: 7711\u20137715.","DOI":"10.1073\/pnas.86.20.7711"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Motohashi H, Shavit JA, Igarashi K, Yamamoto M, Engel JD. The world according to Maf. Nucleic Acids Res.  1997;  25: 2953\u20132959.","DOI":"10.1093\/nar\/25.15.2953"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Blank V, Andrews NC. The Maf transcription factors: regulators of differentiation. Trends Biochem Sci.  1997;  22: 437\u2013441.","DOI":"10.1016\/S0968-0004(97)01105-5"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Motohashi H, Katsuoka F, Shavit JA, Engel JD, Yamamoto M. Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins. Cell.  2000;  103: 865\u2013875.","DOI":"10.1016\/S0092-8674(00)00190-2"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Ogino H, Yasuda K. Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf. Science.  1998;  280: 115\u2013118.","DOI":"10.1126\/science.280.5360.115"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kataoka K, Han SI, Shioda S, Hirai M, Nishizawa M, Handa H. MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem.  2002;  277: 49903\u201349910.","DOI":"10.1074\/jbc.M206796200"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Olbrot M, Rud J, Moss LG, Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci USA.  2002;  99: 6737\u20136742.","DOI":"10.1073\/pnas.102168499"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Zhang C, Moriguchi T, Kajihara M, Esaki R, Harada A, Shimohata H, et al. MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol.  2005;  25: 4969\u20134976.","DOI":"10.1128\/MCB.25.12.4969-4976.2005"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, et al. Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab.  2006;  4: 143\u2013154.","DOI":"10.1016\/j.cmet.2006.06.009"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol.  2006;  293: 526\u2013539.","DOI":"10.1016\/j.ydbio.2006.02.028"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature.  2008;  455: 627\u2013632.","DOI":"10.1038\/nature07314"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Han SI, Aramata S, Yasuda K, Kataoka K. MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3. Mol Cell Biol.  2007;  27: 6593\u20136605.","DOI":"10.1128\/MCB.01573-06"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Rocques N, Abou Zeid N, Sii-Felice K, Lecoin L, Felder-Schmittbuhl MP, Eych\u00e8ne A, et al. GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell.  2007;  28: 584\u2013597.","DOI":"10.1016\/j.molcel.2007.11.009"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Cordes SP, Barsh GS. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell.  1994;  79: 1025\u20131034.","DOI":"10.1016\/0092-8674(94)90033-7"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kataoka K, Fujiwara KT, Noda M, Nishizawa M. MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun. Mol Cell Biol.  1994;  14: 7581\u20137591.","DOI":"10.1128\/mcb.14.11.7581-7591.1994"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Sieweke MH, Tekotte H, Frampton J, Graf T. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell.  1996;  85: 49\u201360.","DOI":"10.1016\/S0092-8674(00)81081-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kelly LM, Englmeier U, Lafon I, Sieweke MH, Graf T. MafB is an inducer of monocytic differentiation. EMBO J.  2000;  19: 1987\u20131997.","DOI":"10.1093\/emboj\/19.9.1987"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sadl V, Jin F, Yu J, Cui S, Holmyard D, Quaggin S, et al. The mouse Kreisler (Krml1\/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells. Dev Biol.  2002;  249: 16\u201329.","DOI":"10.1006\/dbio.2002.0751"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Eichmann A, Grapin-Botton A, Kelly L, Graf T, Le Douarin NM, Sieweke M. The expression pattern of the mafB\/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant. Mech Dev.  1997;  65: 111\u2013122.","DOI":"10.1016\/S0925-4773(97)00063-4"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Blanchi B, Kelly LM, Viemari JC, Lafon I, Burnet H, B\u00e9vengut M, et al. MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. Nat Neurosci.  2003;  6: 1091\u20131100.","DOI":"10.1038\/nn1129"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, et al. MafB is essential for renal development and F4\/80 expression in macrophages. Mol Cell Biol.  2006;  26: 5715\u20135727.","DOI":"10.1128\/MCB.00001-06"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Aziz A, Vanhille L, Mohideen P, Kelly LM, Otto C, Bakri Y, et al. Development of macrophages with altered actin organization in the absence of MafB. Mol Cell Biol.  2006;  26: 6808\u20136818.","DOI":"10.1128\/MCB.00245-06"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kamitani-Kawamoto A, Hamada M, Moriguchi T, Miyai M, Saji F, Hatamura I, et al. MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development. J Bone Miner Res.  2011;  26: 2463\u20132472.","DOI":"10.1002\/jbmr.458"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, et al. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun.  2014;  5: 3147.","DOI":"10.1038\/ncomms4147"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, et al. MafB is a critical regulator of complement component C1q. Nat Commun.  2017;  8: 1700.","DOI":"10.1038\/s41467-017-01711-0"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, et al. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med.  2017;  23: 723\u2013732.","DOI":"10.1038\/nm.4312"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Hamada M, Tsunakawa Y, Jeon H, Yadav MK, Takahashi S. Role of MafB in macrophages. Exp Anim.  2020;  69: 1\u201310.","DOI":"10.1538\/expanim.19-0076"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Usui T, Morito N, Shawki HH, Sato Y, Tsukaguchi H, Hamada M, et al. Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis. Kidney Int.  2020;  98: 391\u2013403.","DOI":"10.1016\/j.kint.2020.02.038"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, et al. MafB is required for islet beta cell maturation. Proc Natl Acad Sci USA.  2007;  104: 3853\u20133858.","DOI":"10.1073\/pnas.0700013104"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Katoh MC, Jung Y, Ugboma CM, Shimbo M, Kuno A, Basha WA, et al. MafB is critical for Glucagon production and secretion in mouse pancreatic \u03b1 cells <i>in vivo<\/i>. Mol Cell Biol.  2018;  38: e00504-17.","DOI":"10.1128\/MCB.00504-17"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Xiafukaiti G, Maimaiti S, Ogata K, Kuno A, Kudo T, Shawki HH, et al. MafB is important for pancreatic \u03b2-cell maintenance under a MafA-deficient condition. Mol Cell Biol.  2019;  39: e00080\u201319.","DOI":"10.1128\/MCB.00080-19"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Sarrazin S, Mossadegh-Keller N, Fukao T, Aziz A, Mourcin F, Vanhille L, et al. MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells. Cell.  2009;  138: 300\u2013313.","DOI":"10.1016\/j.cell.2009.04.057"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Aziz A, Soucie E, Sarrazin S, Sieweke MH. MafB\/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science.  2009;  326: 867\u2013871.","DOI":"10.1126\/science.1176056"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, et al. Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood.  2009;  113: 2976\u20132987.","DOI":"10.1182\/blood-2008-06-164921"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Miyai M, Tanaka YG, Kamitani A, Hamada M, Takahashi S, Kataoka K. c-Maf and MafB transcription factors are differentially expressed in Huxley\u2019s and Henle\u2019s layers of the inner root sheath of the hair follicle and regulate cuticle formation. J Dermatol Sci.  2010;  57: 178\u2013182.","DOI":"10.1016\/j.jdermsci.2009.12.011"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Miyai M, Hamada M, Moriguchi T, Hiruma J, Kamitani-Kawamoto A, Watanabe H, et al. Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation. J Invest Dermatol.  2016;  136: 1848\u20131857.","DOI":"10.1016\/j.jid.2016.05.088"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Suzuki K, Numata T, Suzuki H, Raga DD, Ipulan LA, Yokoyama C, et al. Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation. Proc Natl Acad Sci USA.  2014;  111: 16407\u201316412.","DOI":"10.1073\/pnas.1413273111"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Dieterich LC, Klein S, Mathelier A, Sliwa-Primorac A, Ma Q, Hong YK, et al. DeepCAGE transcriptomics reveal an important role of the transcription factor MAFB in the lymphatic endothelium. Cell Rep.  2015;  13: 1493\u20131504.","DOI":"10.1016\/j.celrep.2015.10.002"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Dieterich LC, Tacconi C, Menzi F, Proulx ST, Kapaklikaya K, Hamada M, et al. Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis. Angiogenesis.  2020;  23: 411\u2013423.","DOI":"10.1007\/s10456-020-09721-1"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40. Ho IC, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell.  1996;  85: 973\u2013983.","DOI":"10.1016\/S0092-8674(00)81299-4"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Imbratta C, Hussein H, Andris F, Verdeil G. c-MAF, a Swiss army knife for tolerance in lymphocytes. Front Immunol.  2020;  11: 206.","DOI":"10.3389\/fimmu.2020.00206"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, et al. Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem.  1999;  274: 19254\u201319260.","DOI":"10.1074\/jbc.274.27.19254"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Kim JI, Li T, Ho IC, Grusby MJ, Glimcher LH. Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc Natl Acad Sci USA.  1999;  96: 3781\u20133785.","DOI":"10.1073\/pnas.96.7.3781"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Nishikawa K, Nakashima T, Takeda S, Isogai M, Hamada M, Kimura A, et al. Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest.  2010;  120: 3455\u20133465.","DOI":"10.1172\/JCI42528"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Kusakabe M, Hasegawa K, Hamada M, Nakamura M, Ohsumi T, Suzuki H, et al. c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver. Blood.  2011;  118: 1374\u20131385.","DOI":"10.1182\/blood-2010-08-300400"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Nakamura M, Hamada M, Hasegawa K, Kusakabe M, Suzuki H, Greaves DR, et al. c-Maf is essential for the F4\/80 expression in macrophages in vivo. Gene.  2009;  445: 66\u201372.","DOI":"10.1016\/j.gene.2009.06.003"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Fujino M, Tagami A, Ojima M, Mizuno S, Abdellatif AM, Kuno A, et al. c-MAF deletion in adult C57BL\/6J mice induces cataract formation and abnormal differentiation of lens fiber cells. Exp Anim.  2020;  69: 242\u2013249.","DOI":"10.1538\/expanim.19-0137"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Swaroop A, Xu JZ, Pawar H, Jackson A, Skolnick C, Agarwal N. A conserved retina-specific gene encodes a basic motif\/leucine zipper domain. Proc Natl Acad Sci USA.  1992;  89: 266\u2013270.","DOI":"10.1073\/pnas.89.1.266"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, et al. Nrl is required for rod photoreceptor development. Nat Genet.  2001;  29: 447\u2013452.","DOI":"10.1038\/ng774"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Iacovazzo D, Flanagan SE, Walker E, Quezado R, de Sousa Barros FA, Caswell R, et al. <i>MAFA<\/i> missense mutation causes familial insulinomatosis and diabetes mellitus. Proc Natl Acad Sci USA.  2018;  115: 1027\u20131032.","DOI":"10.1073\/pnas.1712262115"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Zankl A, Duncan EL, Leo PJ, Clark GR, Glazov EA, Addor MC, et al. Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. Am J Hum Genet.  2012;  90: 494\u2013501.","DOI":"10.1016\/j.ajhg.2012.01.003"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Park JG, Tischfield MA, Nugent AA, Cheng L, Di Gioia SA, Chan WM, et al. Loss of MAFB function in humans and mice causes Duane Syndrome, aberrant extraocular muscle innervation, and inner-ear defects. Am J Hum Genet.  2016;  98: 1220\u20131227.","DOI":"10.1016\/j.ajhg.2016.03.023"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Sato Y, Tsukaguchi H, Morita H, Higasa K, Tran MTN, Hamada M, et al. A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome. Kidney Int.  2018;  94: 396\u2013407.","DOI":"10.1016\/j.kint.2018.02.025"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Jamieson RV, Perveen R, Kerr B, Carette M, Yardley J, Heon E, et al. Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma. Hum Mol Genet.  2002;  11: 33\u201342.","DOI":"10.1093\/hmg\/11.1.33"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, et al. The transcription factor c-Maf controls touch receptor development and function. Science.  2012;  335: 1373\u20131376.","DOI":"10.1126\/science.1214314"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Niceta M, Stellacci E, Gripp KW, Zampino G, Kousi M, Anselmi M, et al. Mutations impairing GSK3-mediated MAF phosphorylation cause cataract, deafness, intellectual disability, seizures, and a Down Syndrome-like facies. Am J Hum Genet.  2015;  96: 816\u2013825.","DOI":"10.1016\/j.ajhg.2015.03.001"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Bessant DA, Payne AM, Mitton KP, Wang QL, Swain PK, Plant C, et al. A mutation in NRL is associated with autosomal dominant retinitis pigmentosa. Nat Genet.  1999;  21: 355\u2013356.","DOI":"10.1038\/7678"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Qin Y, Liu F, Yu S, Yang L, Gao M, Tang Z, et al. Identification of a novel NRL mutation in a Chinese family with retinitis pigmentosa by whole-exome sequencing. Eye (Lond).  2017;  31: 815\u2013817.","DOI":"10.1038\/eye.2016.327"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Littink KW, Stappers PTY, Riemslag FCC, Talsma HE, van Genderen MM, Cremers FPM, et al. Autosomal Recessive NRL Mutations in Patients with Enhanced S-Cone Syndrome. Genes (Basel).  2018;  9: 68.","DOI":"10.3390\/genes9020068"},{"key":"60","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood.V90.2.526","volume":"90","year":"1997","unstructured":"60. Nishida K, Tamura A, Nakazawa N, Ueda Y, Abe T, Matsuda F, et al. The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization. Blood.  1997;  90: 526\u2013534.","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"61","doi-asserted-by":"publisher","unstructured":"61. Bergsagel PL, Kuehl WM. Chromosome translocations in multiple myeloma. Oncogene.  2001;  20: 5611\u20135622.","DOI":"10.1038\/sj.onc.1204641"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Hanamura I, Iida S, Akano Y, Hayami Y, Kato M, Miura K, et al. Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations. Jpn J Cancer Res.  2001;  92: 638\u2013644.","DOI":"10.1111\/j.1349-7006.2001.tb01142.x"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Hanamura I, Iida S, Ueda R, Kuehl M, Cullraro C, Bergsagel L, et al.  Identification of three novel chromosomal translocation partners involving the immunoglobulin loci in newly diagnosed myeloma and human myeloma cell lines. ASH Annual Meeting Abstracts.  2005; 106: 1552.","DOI":"10.1182\/blood.V106.11.1552.1552"},{"key":"64","doi-asserted-by":"publisher","unstructured":"64. Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell.  2004;  5: 191\u2013199.","DOI":"10.1016\/S1535-6108(04)00019-4"},{"key":"65","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1038\/sj.onc.1208844","volume":"24","year":"2005","unstructured":"65. Suzuki A, Iida S, Kato-Uranishi M, Tajima E, Zhan F, Hanamura I, et al. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. Oncogene.  2005;  24: 6936\u20136944.","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Morito N, Yoh K, Maeda A, Nakano T, Fujita A, Kusakabe M, et al. A novel transgenic mouse model of the human multiple myeloma chromosomal translocation t(14;16)(q32;q23). Cancer Res.  2011;  71: 339\u2013348.","DOI":"10.1158\/0008-5472.CAN-10-1057"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/70\/3\/70_21-0027\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T03:54:24Z","timestamp":1628308464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/70\/3\/70_21-0027\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.21-0027","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"21-0027"}}