{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:36:07Z","timestamp":1790199367636,"version":"4.1.0"},"reference-count":38,"publisher":"Japanese Association for Laboratory Animal Science","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2022]]},"DOI":"10.1538\/expanim.21-0143","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T22:08:07Z","timestamp":1639519687000},"page":"224-230","source":"Crossref","is-referenced-by-count":10,"title":["Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats"],"prefix":"10.1538","volume":"71","author":[{"given":"Cebrail","family":"Gursul","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, Basbaglar Street, 24030, Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalet","family":"Ozcicek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Erzincan Binali Yildirim University, Basbaglar Street, 24030, Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ozkaraca","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, 69 Kayseri Street, 58140, Sivas, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Sefa","family":"Mendil","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Erciyes University, 55 Hulusi Behcet Street, 38280, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha Abdulkadir","family":"Coban","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Erzincan Binali Yildirim University, Basbaglar Street, 24030, Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Halic University, 15 Temmuz Sehitler Street, Eyup, 34060, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ozcicek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Erzincan Binali Yildirim University, Basbaglar Street, 24030, Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halis","family":"Suleyman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Basbaglar Street, 24030, Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"439","reference":[{"key":"1","unstructured":"1. Prabhakaran V, Ettler H, Mills A. Methanol poisoning: two cases with similar plasma methanol concentrations but different outcomes. CMAJ.  1993;  148: 981\u2013984."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Yazgan \u00dcC, Elbey B, Ku\u015f S, Baykal B, Keskin I, Y\u0131lmaz A, et al. Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication. Ir J Med Sci.  2017;  186: 519\u2013523.","DOI":"10.1007\/s11845-016-1462-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA. American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol.  2002;  40: 415\u2013446.","DOI":"10.1081\/CLT-120006745"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hayreh MS, Hayreh SS, Baumbach GL, Cancilla P, Martin-Amat G, Tephly TR, et al. Methyl alcohol poisoning III. Ocular toxicity. Arch Ophthalmol.  1977;  95: 1851\u20131858.","DOI":"10.1001\/archopht.1977.04450100153022"},{"key":"5","unstructured":"5. Hantson PE. [Acute methanol intoxication: physiopathology, prognosis and treatment]. Bull Mem Acad R Med Belg.  2006;  161: 425\u2013434, discussion 434\u2013436. (in French)"},{"key":"6","unstructured":"6. Liesivuori J, Kosma VM, Naukkarinen A, Savolainen H. Kinetics and toxic effects of repeated intravenous dosage of formic acid in rabbits. Br J Exp Pathol.  1987;  68: 853\u2013861."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Ereci\u0144ska M, Wilson DF. Inhibitors of cytochrome c oxidase. Pharmacol Ther.  1980;  8: 1\u201320.","DOI":"10.1016\/0163-7258(80)90057-1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bralet J, Bouvier C, Schreiber L, Boquillon M. Effect of acidosis on lipid peroxidation in brain slices. Brain Res.  1991;  539: 175\u2013177.","DOI":"10.1016\/0006-8993(91)90703-X"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Skrzydlewska E, Farbiszewski R. Decreased antioxidant defense mechanisms in rat liver after methanol intoxication. Free Radic Res.  1997;  27: 369\u2013375.","DOI":"10.3109\/10715769709065776"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kurcer MA, Kurcer Z, Koksal M, Baba F, Ocak AR, Aksoy N, et al. Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole. J Med Food.  2010;  13: 985\u2013991.","DOI":"10.1089\/jmf.2009.0166"},{"key":"11","unstructured":"11. Eells JT, Henry MM, Lewandowski MF, Seme MT, Murray TG. Development and characterization of a rodent model of methanol-induced retinal and optic nerve toxicity. Neurotoxicology.  2000;  21: 321\u2013330."},{"key":"12","unstructured":"12. Karadayi M, Yildirim V, G\u00fcll\u00fcce M. Antimicrobial activity and other biological properties of oregano essential oil and carvacrol. Anatol J Biol. 1: 52\u201368."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Suntres ZE, Coccimiglio J, Alipour M. The bioactivity and toxicological actions of carvacrol. Crit Rev Food Sci Nutr.  2015;  55: 304\u2013318.","DOI":"10.1080\/10408398.2011.653458"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ezz-Eldin YM, Aboseif AA, Khalaf MM. Potential anti-inflammatory and immunomodulatory effects of carvacrol against ovalbumin-induced asthma in rats. Life Sci.  2020;  242: 117222.","DOI":"10.1016\/j.lfs.2019.117222"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yu H, Zhang ZL, Chen J, Pei A, Hua F, Qian X, et al. Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia\/reperfusion injury in mice. PLoS One.  2012;  7: e33584.","DOI":"10.1371\/journal.pone.0033584"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem.  1979;  95: 351\u2013358.","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem.  1968;  25: 192\u2013205.","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem.  2004;  37: 112\u2013119.","DOI":"10.1016\/j.clinbiochem.2003.10.014"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem.  2005;  38: 1103\u20131111.","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kisaoglu A, Borekci B, Yapca OE, Bilen H, Suleyman H. Tissue damage and oxidant\/antioxidant balance. Eurasian J Med.  2013;  45: 47\u201349.","DOI":"10.5152\/eajm.2013.08"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Skrzydlewska E, Farbiszewski R. Liver and serum antioxidant status after methanol intoxication in rats. Acta Biochim Pol.  1997;  44: 139\u2013145.","DOI":"10.18388\/abp.1997_4451"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Eells JT, Salzman MM, Lewandowski MF, Murray TG. Formate-induced alterations in retinal function in methanol-intoxicated rats. Toxicol Appl Pharmacol.  1996;  140: 58\u201369.","DOI":"10.1006\/taap.1996.0197"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Lanigan S. Final report on the safety assessment of Methyl Alcohol. Int J Toxicol.  2001;  20:(Suppl 1): 57\u201385.","DOI":"10.1080\/109158101750300955"},{"key":"24","unstructured":"24. Pizzorno J. Glutathione!Integr Med (Encinitas).  2014;  13: 8\u201312."},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A, Berardo C. Changes in glutathione content in liver diseases: an update. Antioxidants.  2021;  10: 364.","DOI":"10.3390\/antiox10030364"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Lushchak VI. Glutathione homeostasis and functions: potential targets for medical interventions. J Amino Acids.  2012;  2012: 736837.","DOI":"10.1155\/2012\/736837"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Kozak HH, K\u0131l\u0131n\u00e7 \u0130, \u00d6zk\u00fcrk\u00e7\u00fcler A. Biochemical evaluation of the effects of quercetin on experimental acute methanol intoxication in rats. J Pharm Res Int.  2020;  32: 195\u2013201.","DOI":"10.9734\/jpri\/2020\/v32i2030743"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hamouda F, Nadia N, El-Kersh M. Study on Agarwood and caspase-3 activation in rat liver toxicity induced by methanol. Pharm Pharmacol Int J.  2018;  6: 127\u2013130.","DOI":"10.15406\/ppij.2018.06.00168"},{"key":"29","unstructured":"29. Wallach JB. Interpretation of diagnostic tests: Lippincott Williams & Wilkins;  2007."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Fickert P, Zatloukal K. Pathogenesis of alcoholic liver disease. In: Handbook of alcoholism. CRC Press;  2000. pp. 341\u2013348.","DOI":"10.1201\/9781420036961-39"},{"key":"31","unstructured":"31. Desai SP. Clinician\u2019s guide to laboratory medicine: a practical approach. Lexi-Comp;  2004."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Khan I, Bhardwaj M, Shukla S, Min SH, Choi DK, Bajpai VK, et al. Carvacrol inhibits cytochrome P450 and protects against binge alcohol-induced liver toxicity. Food Chem Toxicol.  2019;  131: 110582.","DOI":"10.1016\/j.fct.2019.110582"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Allis JW, Brown BL, Simmons JE, Hatch GE, McDonald A, House DE. Methanol potentiation of carbon tetrachloride hepatotoxicity: the central role of cytochrome P450. Toxicology.  1996;  112: 131\u2013140.","DOI":"10.1016\/0300-483X(96)03366-5"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Kim E, Choi Y, Jang J, Park T. Carvacrol protects against hepatic steatosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling. Evid Based Complement Alternat Med.  2013;  2013: 290104.","DOI":"10.1155\/2013\/290104"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Nazari A, Fanaei H, Dehpour AR, Hassanzadeh G, Jafari M, Salehi M, et al. Chemical composition and hepatoprotective activity of ethanolic root extract of Taraxacum Syriacum Boiss against acetaminophen intoxication in rats. Bratisl Lek Listy.  2015;  116: 41\u201346.","DOI":"10.4149\/BLL_2015_008"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Akhgari M, Panahianpour MH, Bazmi E, Etemadi-Aleagha A, Mahdavi A, Nazari SH. Fatal methanol poisoning: features of liver histopathology. Toxicol Ind Health.  2013;  29: 136\u2013141.","DOI":"10.1177\/0748233711427050"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Dobrzy\u00f1ska I, Skrzydlewska E, Kasacka I, Figaszewski Z. Protective effect of N-acetylcysteine on rat liver cell membrane during methanol intoxication. J Pharm Pharmacol.  2000;  52: 547\u2013552.","DOI":"10.1211\/0022357001774183"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Kurcer Z, O\u011fuz E, Iraz M, Fadillioglu E, Baba F, Koksal M, et al. Melatonin improves methanol intoxication-induced oxidative liver injury in rats. J Pineal Res.  2007;  43: 42\u201349.","DOI":"10.1111\/j.1600-079X.2007.00441.x"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/71\/2\/71_21-0143\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T04:35:18Z","timestamp":1653107718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/71\/2\/71_21-0143\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.21-0143","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"21-0143"}}