{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T22:40:42Z","timestamp":1736635242117,"version":"3.32.0"},"reference-count":50,"publisher":"Japanese Association for Laboratory Animal Science","issue":"1","funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101601"],"award-info":[{"award-number":["2021YFA1101601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2025]]},"DOI":"10.1538\/expanim.24-0012","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T22:10:46Z","timestamp":1720563046000},"page":"16-30","source":"Crossref","is-referenced-by-count":0,"title":["Dosage and organic acid residue of myelin oligodendrocyte glycoprotein&lt;sub&gt;35\u201355&lt;\/sub&gt; peptide influences immunopathology and development of Bacillus Calmette-Gu\u00e9rin induced experimental autoimmune encephalomyelitis"],"prefix":"10.1538","volume":"74","author":[{"given":"Xiaoyan","family":"Han","sequence":"first","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Na","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Hao","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haohan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufang","family":"Meng","sequence":"additional","affiliation":[{"name":"Cell Collection and Research Center, National Institutes for Food and Drug Control, 31 Huatuo Road, Daxing District, Beijing, 102629, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"439","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Constantinescu CS, Farooqi N, O\u2019Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol.  2011;  164: 1079\u20131106.","DOI":"10.1111\/j.1476-5381.2011.01302.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Olek MJ. Multiple Sclerosis. Ann Intern Med.  2021;  174: ITC81\u2013ITC96.","DOI":"10.7326\/AITC202106150"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Contarini G, Giusti P, Skaper SD. Active induction of experimental autoimmune encephalomyelitis in C57BL\/6 Mice. Methods Mol Biol.  2018;  1727: 353\u2013360.","DOI":"10.1007\/978-1-4939-7571-6_26"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Mendel I, Kerlero de Rosbo N, Ben-Nun A. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur J Immunol.  1995;  25: 1951\u20131959.","DOI":"10.1002\/eji.1830250723"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, et al. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity.  2011;  35: 273\u2013284.","DOI":"10.1016\/j.immuni.2011.06.011"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, et al. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep.  2016;  15: 2136\u20132146.","DOI":"10.1016\/j.celrep.2016.05.009"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kim SS, Richman DP, Zamvil SS, Agius MA. Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice. J Neurol Sci.  2011;  306: 9\u201315.","DOI":"10.1016\/j.jns.2011.04.008"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Boullerne AI, Polak PE, Braun D, Sharp A, Pelligrino D, Feinstein DL. Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis. J Neurochem.  2014;  129: 696\u2013703.","DOI":"10.1111\/jnc.12664"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Aharoni R, Globerman R, Eilam R, Brenner O, Arnon R. Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model. J Neurosci Methods.  2021;  351: 108999.","DOI":"10.1016\/j.jneumeth.2020.108999"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yin JX, Tang Z, Gan Y, Li L, Shi F, Coons S, et al. Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis. Neuropharmacology.  2014;  81: 1\u20135.","DOI":"10.1016\/j.neuropharm.2014.01.027"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Pai M, Behr MA, Dowdy D, Dheda K, Divangahi M, Boehme CC, et al. Tuberculosis. Nat Rev Dis Primers.  2016;  2: 16076.","DOI":"10.1038\/nrdp.2016.76"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kowalewicz-Kulbat M, Locht C. BCG and protection against inflammatory and auto-immune diseases. Expert Rev Vaccines.  2017;  16: 1\u201310.","DOI":"10.1080\/14760584.2017.1333906"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Sewell DL, Reinke EK, Co DO, Hogan LH, Fritz RB, Sandor M, et al. Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. Clin Diagn Lab Immunol.  2003;  10: 564\u2013572.","DOI":"10.1128\/CDLI.10.4.564-572.2003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lippens C, Garnier L, Guyonvarc\u2019h PM, Santiago-Raber ML, Hugues S. Extended Freeze-Dried BCG Instructed pDCs Induce Suppressive Tregs and Dampen EAE. Front Immunol.  2018;  9: 2777.","DOI":"10.3389\/fimmu.2018.02777"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Lee J, Reinke EK, Zozulya AL, Sandor M, Fabry Z. Mycobacterium bovis bacille Calmette-Gu\u00e9rin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. J Immunol.  2008;  181: 6201\u20136212.","DOI":"10.4049\/jimmunol.181.9.6201"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Seo JE, Hasan M, Han JS, Kim NK, Lee JE, Lee KM, et al. Dependency of Experimental Autoimmune Encephalomyelitis Induction on MOG35-55 Properties Modulating Matrix Metalloproteinase-9 and Interleukin-6. Neurochem Res.  2016;  41: 666\u2013676.","DOI":"10.1007\/s11064-015-1732-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Dias AT, De Castro SB, Alves CC, Mesquita FP, De Figueiredo NS, Evangelista MG, et al. Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-\u03b2 in mice CNS despite unchanged clinical course. Cell Immunol.  2015;  293: 87\u201394.","DOI":"10.1016\/j.cellimm.2014.12.009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Castoldi V, Marenna S, Huang SC, d\u2019Isa R, Chaabane L, Comi G, et al. Dose-dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis. J Neurosci Res.  2022;  100: 855\u2013868.","DOI":"10.1002\/jnr.25007"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Wang Z, Hong J, Sun W, Xu G, Li N, Chen X, et al. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest.  2006;  116: 2434\u20132441.","DOI":"10.1172\/JCI25826"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, et al. Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1\u03b2-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity.  2020;  52: 342\u2013356.e6.","DOI":"10.1016\/j.immuni.2020.01.002"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Terry RL, Ifergan I, Miller SD. Experimental Autoimmune Encephalomyelitis in Mice. Methods Mol Biol.  2016;  1304: 145\u2013160.","DOI":"10.1007\/7651_2014_88"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Murayama MA, Chi HH, Matsuoka M, Ono T, Iwakura Y. The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation. Front Immunol.  2021;  12: 607346.","DOI":"10.3389\/fimmu.2021.607346"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Seno A, Maruhashi T, Kaifu T, Yabe R, Fujikado N, Ma G, et al. Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. Exp Anim.  2015;  64: 109\u2013119.","DOI":"10.1538\/expanim.14-0079"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature.  2011;  479: 538\u2013541.","DOI":"10.1038\/nature10554"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Huntemann N, Vogelsang A, Groeneweg L, Willison A, Herrmann AM, Meuth SG, et al. An optimized and validated protocol for inducing chronic experimental autoimmune encephalomyelitis in C57BL\/6J mice. J Neurosci Methods.  2022;  367: 109443.","DOI":"10.1016\/j.jneumeth.2021.109443"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Weber MS, Benkhoucha M, Lehmann-Horn K, Hertzenberg D, Sellner J, Santiago-Raber ML, et al. Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease. PLoS One.  2010;  5: e16009.","DOI":"10.1371\/journal.pone.0016009"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Ristori G, Buzzi MG, Sabatini U, Giugni E, Bastianello S, Viselli F, et al. Use of Bacille Calmette-Gu\u00e8rin (BCG) in multiple sclerosis. Neurology.  1999;  53: 1588\u20131589.","DOI":"10.1212\/WNL.53.7.1588"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, et al. Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS. Neurology.  2014;  82: 41\u201348.","DOI":"10.1212\/01.wnl.0000438216.93319.ab"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. K\u00fchtreiber WM, Tran L, Kim T, Dybala M, Nguyen B, Plager S, et al. Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations. NPJ Vaccines.  2018;  3: 23.","DOI":"10.1038\/s41541-018-0062-8"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Matsuzaki G, Teruya N, Kiyohara Kohama H, Arai K, Shibuya Y, Chuma Y, et al. <i>Mycobacterium bovis<\/i> BCG-mediated suppression of Th17 response in mouse experimental autoimmune encephalomyelitis. Immunopharmacol Immunotoxicol.  2021;  43: 203\u2013211.","DOI":"10.1080\/08923973.2021.1878215"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Namer IJ, Steibel J, Poulet P, Mauss Y, Mohr M, Chambron J. The role of Mycobacterium tuberculosis in experimental allergic encephalomyelitis. Eur Neurol.  1994;  34: 224\u2013227.","DOI":"10.1159\/000117043"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Awate S, Babiuk LA, Mutwiri G. Mechanisms of action of adjuvants. Front Immunol.  2013;  4: 114.","DOI":"10.3389\/fimmu.2013.00114"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Cossu D, Yokoyama K, Hattori N. Conflicting Role of <i>Mycobacterium<\/i> Species in Multiple Sclerosis. Front Neurol.  2017;  8: 216.","DOI":"10.3389\/fneur.2017.00216"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Pu W, Zhao C, Wazir J, Su Z, Niu M, Song S, et al. Comparative transcriptomic analysis of THP-1-derived macrophages infected with Mycobacterium tuberculosis H37Rv, H37Ra and BCG. J Cell Mol Med.  2021;  25: 10504\u201310520.","DOI":"10.1111\/jcmm.16980"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Haile M, Schr\u00f6der U, Hamasur B, Pawlowski A, Jaxmar T, K\u00e4llenius G, et al. Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guerin (BCG) in Eurocine L3 adjuvant protects against tuberculosis. Vaccine.  2004;  22: 1498\u20131508.","DOI":"10.1016\/j.vaccine.2003.10.016"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Sousa-Vasconcelos PS, Seguins WS, Luz ES, Pinho RT. Pattern of cytokine and chemokine production by THP-1 derived macrophages in response to live or heat-killed Mycobacterium bovis bacillus Calmette-Gu\u00e9rin Moreau strain. Mem Inst Oswaldo Cruz.  2015;  110: 809\u2013813.","DOI":"10.1590\/0074-02760140420"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. van der Heijden EMDL, Chileshe J, Vernooij JCM, Gortazar C, Juste RA, Sevilla I, et al. Immune response profiles of calves following vaccination with live BCG and inactivated Mycobacterium bovis vaccine candidates. PLoS One.  2017;  12: e0188448.","DOI":"10.1371\/journal.pone.0188448"},{"key":"38","doi-asserted-by":"publisher","unstructured":"38. Critchfield JM, Racke MK, Z\u00fa\u00f1iga-Pfl\u00fccker JC, Cannella B, Raine CS, Goverman J, et al. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science.  1994;  263: 1139\u20131143.","DOI":"10.1126\/science.7509084"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, et al. Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc Natl Acad Sci USA.  2007;  104: 920\u2013925.","DOI":"10.1073\/pnas.0608383104"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Li J, Lu L, Binder K, Xiong J, Ye L, Cheng YH, et al. Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease. Sci Adv.  2023;  9: eabo2810.","DOI":"10.1126\/sciadv.abo2810"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Zheng P, Fu H, Wei G, Wei Z, Zhang J, Ma X, et al. Antigen-oriented T cell migration contributes to myelin peptide induced-EAE and immune tolerance. Clin Immunol.  2016;  169: 36\u201346.","DOI":"10.1016\/j.clim.2016.06.004"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Ishigami T, White CA, Pender MP. Soluble antigen therapy induces apoptosis of autoreactive T cells preferentially in the target organ rather than in the peripheral lymphoid organs. Eur J Immunol.  1998;  28: 1626\u20131635.","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1626::AID-IMMU1626>3.0.CO;2-B"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Jiang Z, Li H, Fitzgerald DC, Zhang GX, Rostami A. MOG(35-55) i.v suppresses experimental autoimmune encephalomyelitis partially through modulation of Th17 and JAK\/STAT pathways. Eur J Immunol.  2009;  39: 789\u2013799.","DOI":"10.1002\/eji.200838427"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ehirchiou D, Xiong Y, Xu G, Chen W, Shi Y, Zhang L. CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation. J Exp Med.  2007;  204: 1519\u20131524.","DOI":"10.1084\/jem.20062292"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Li H, Zhang GX, Chen Y, Xu H, Fitzgerald DC, Zhao Z, et al. CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. J Immunol.  2008;  181: 2483\u20132493.","DOI":"10.4049\/jimmunol.181.4.2483"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Wang L, Li Z, Ciric B, Safavi F, Zhang GX, Rostami A. Selective depletion of CD11c<sup>+<\/sup> CD11b<sup>+<\/sup> dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE. Eur J Immunol.  2016;  46: 2454\u20132466.","DOI":"10.1002\/eji.201546274"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Gaikwad WK, Dhere RM, Jana SK, Mallya AD, Soni DJ, Gholap M, et al. Effect of trifluoroacetic acid on the antigenicity of capsular polysaccharides obtained from various Streptococcus pneumoniae serotypes. Carbohydr Polym.  2023;  320: 121204.","DOI":"10.1016\/j.carbpol.2023.121204"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. You Q, Cheng L, Ju C. Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicol Lett.  2010;  194: 79\u201385.","DOI":"10.1016\/j.toxlet.2010.02.009"},{"key":"49","doi-asserted-by":"publisher","unstructured":"49. You Q, Cheng L, Reilly TP, Wegmann D, Ju C. Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology.  2006;  44: 1421\u20131431.","DOI":"10.1002\/hep.21425"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Delluc S, Tourneur L, Fradelizi D, Rubio MT, Marchiol-Fournigault C, Chiocchia G, et al. DC-based vaccine loaded with acid-eluted peptides in acute myeloid leukemia: the importance of choosing the best elution method. Cancer Immunol Immunother.  2007;  56: 1\u201312.","DOI":"10.1007\/s00262-006-0170-6"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/74\/1\/74_24-0012\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T03:22:11Z","timestamp":1736565731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/74\/1\/74_24-0012\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.24-0012","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"type":"print","value":"1341-1357"},{"type":"electronic","value":"1881-7122"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"24-0012"}}