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Foster J, Frost D. The History of the rat. In: Suttie AW, Leininger JR, Bradley AE, editors. Boorman\u2019s pathology of the rat. Reference and atlas, second edition. London: Academic Press;  2018. pp. 7\u201312.","DOI":"10.1016\/B978-0-12-391448-4.00003-4"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Jacobs AC, Hatfield KP. History of chronic toxicity and animal carcinogenicity studies for pharmaceuticals. Vet Pathol.  2013;  50: 324\u2013333.","DOI":"10.1177\/0300985812450727"},{"key":"3","unstructured":"3. Lindsey JR, Baker HJ. Historical foundations. In: Suckow MA, Weisbroth SH, Franklin CL, editors. The laboratory rat, second edition. London: Academic Press;  2005. pp. 1\u201352."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Weber K, Razinger T, Hardisty JF, Mann P, Martel KC, Frische EA, et al. Differences in rat models used in routine toxicity studies. Int J Toxicol.  2011;  30: 162\u2013173.","DOI":"10.1177\/1091581810391818"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Poteracki J, Walsh KM. Spontaneous neoplasms in control Wistar rats: a comparison of reviews. Toxicol Sci.  1998;  45: 1\u20138.","DOI":"10.1093\/toxsci\/45.1.1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. McMartin DN, Sahota PS, Gunson DE, Hsu HH, Spaet RH. Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicol Pathol.  1992;  20: 212\u2013225.","DOI":"10.1177\/019262339202000208"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. King-Herbert A, Thayer K. NTP workshop: animal models for the NTP rodent cancer bioassay: stocks and strains--should we switch? Toxicol Pathol.  2006;  34: 802\u2013805.","DOI":"10.1080\/01926230600935938"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature.  2000;  408: 255\u2013262.","DOI":"10.1038\/35041700"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing. Eur Respir J.  1999;  13: 197\u2013205.","DOI":"10.1034\/j.1399-3003.1999.13a36.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Bourdi M, Davies JS, Pohl LR. Mispairing C57BL\/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury. Chem Res Toxicol.  2011;  24: 794\u2013796.","DOI":"10.1021\/tx200143x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Mekada K, Yoshiki A. Substrains matter in phenotyping of C57BL\/6 mice. Exp Anim.  2021;  70: 145\u2013160.","DOI":"10.1538\/expanim.20-0158"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ulmasov B, Oshima K, Rodriguez MG, Cox RD, Neuschwander-Tetri BA. Differences in the degree of cerulein-induced chronic pancreatitis in C57BL\/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis. Am J Pathol.  2013;  183: 692\u2013708.","DOI":"10.1016\/j.ajpath.2013.05.020"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Smits BMG, van Zutphen BFM, Plasterk RHA, Cuppen E. Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res.  2004;  14: 1285\u20131290.","DOI":"10.1101\/gr.2155004"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Smits BM, Guryev V, Zeegers D, Wedekind D, Hedrich HJ, Cuppen E. Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. BMC Genomics.  2005;  6: 170.","DOI":"10.1186\/1471-2164-6-170"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Brekke TD, Steele KA, Mulley JF. Inbred or outbred? Genetic diversity in laboratory rodent colonies. G3 (Bethesda).  2018;  8: 679\u2013686.","DOI":"10.1534\/g3.117.300495"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kawaguchi K, Asai A, Mikawa R, Ogiso N, Sugimoto M. Age-related changes in lung function in national center for geriatrics and gerontology aging farm C57BL\/6N mice. Exp Anim.  2023;  72: 173\u2013182.","DOI":"10.1538\/expanim.22-0109"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Fedrowitz M, Kamino K, L\u00f6scher W. Significant differences in the effects of magnetic field exposure on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in two substrains of Sprague-Dawley rats. Cancer Res.  2004;  64: 243\u2013251.","DOI":"10.1158\/0008-5472.CAN-03-2808"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Gordon CJ, Watkinson WP. Strain differences in the laboratory rat: impact on the autonomic, behavioral, and biochemical response to cholinesterase inhibition. J Toxicol Environ Health.  1995;  45: 59\u201373.","DOI":"10.1080\/15287399509531980"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Murata N, Yabuki A, Matsumoto M, Nishinakagawa H, Suzuki S. Strain differences in morphometrical characteristics of rat kidneys. J Vet Med Sci.  2006;  68: 1185\u20131189.","DOI":"10.1292\/jvms.68.1185"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Schmitt U, Hiemke C. Strain differences in open-field and elevated plus-maze behavior of rats without and with pretest handling. Pharmacol Biochem Behav.  1998;  59: 807\u2013811.","DOI":"10.1016\/S0091-3057(97)00502-9"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Rinwa P, Eriksson M, Cotgreave I, B\u00e4ckberg M. 3R-Refinement principles: elevating rodent well-being and research quality. 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Toxicol Pathol.  1997;  25: 256\u2013263.","DOI":"10.1177\/019262339702500302"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Hard GC, Khan KN. A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol Pathol.  2004;  32: 171\u2013180.","DOI":"10.1080\/01926230490422574"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hard GC, Seely JC. Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN). Toxicol Pathol.  2005;  33: 641\u2013649.","DOI":"10.1080\/01926230500299716"},{"key":"34","doi-asserted-by":"publisher","unstructured":"34. Egalini F, Marinelli L, Rossi M, Motta G, Prencipe N, Rossetto Giaccherino R, et al. Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands. 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Sandusky GE, Van Pelt CS, Todd GC, Wightman K. An immunocytochemical study of pituitary adenomas and focal hyperplasia in old Sprague-Dawley and Fischer 344 rats. Toxicol Pathol.  1988;  16: 376\u2013380.","DOI":"10.1177\/019262338801600309"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Seely JC, Hard GC. Chronic progressive nephropathy (CPN) in the rat: review of pathology and relationship to renal tumorigenesis. J Toxicol Pathol.  2008;  21: 199\u2013205.","DOI":"10.1293\/tox.21.199"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Okamura T, Suzuki S, Ogawa T, Kobayashi J, Kusuoka O, Hatayama K, et al. Background data for general toxicology parameters in RccHan:WIST rats at 8, 10, 19 and 32 Weeks of Age. J Toxicol Pathol.  2011;  24: 195\u2013205.","DOI":"10.1293\/tox.24.195"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Hayakawa K, Mimura Y, Tachibana S, Furuya M, Kodama T, Aoki T, et al. 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