{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:09:32Z","timestamp":1793329772551,"version":"4.5.0"},"reference-count":64,"publisher":"Japanese Association for Laboratory Animal Science","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2025]]},"DOI":"10.1538\/expanim.24-0133","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T22:11:06Z","timestamp":1732313466000},"page":"132-142","source":"Crossref","is-referenced-by-count":15,"title":["Adriamycin-induced nephropathy models: elucidating CKD pathophysiology and advancing therapeutic strategies"],"prefix":"10.1538","volume":"74","author":[{"given":"Masaki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato R.","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuya","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"439","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet.  2017;  390: 1151\u20131210.","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2. Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet.  2021;  398: 786\u2013802.","DOI":"10.1016\/S0140-6736(21)00519-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kopp JB, Anders HJ, Susztak K, Podest\u00e0 MA, Remuzzi G, Hildebrandt F, et al. Podocytopathies. Nat Rev Dis Primers.  2020;  6: 68.","DOI":"10.1038\/s41572-020-0196-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tryggvason K, Wartiovaara J. Molecular basis of glomerular permselectivity. Curr Opin Nephrol Hypertens.  2001;  10: 543\u2013549.","DOI":"10.1097\/00041552-200107000-00009"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kurts C, Panzer U, Anders HJ, Rees AJ. The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol.  2013;  13: 738\u2013753.","DOI":"10.1038\/nri3523"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Soderland P, Lovekar S, Weiner DE, Brooks DR, Kaufman JS. Chronic kidney disease associated with environmental toxins and exposures. Adv Chronic Kidney Dis.  2010;  17: 254\u2013264.","DOI":"10.1053\/j.ackd.2010.03.011"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. McKinley JM, Mueller U, Atkinson PM, Ofterdinger U, Jackson C, Cox SF, et al. Investigating the influence of environmental factors on the incidence of renal disease with compositional data analysis using balances. Appl Comput Geosci.  2020;  6: 100024.","DOI":"10.1016\/j.acags.2020.100024"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Meyer TN, Schwesinger C, Wahlefeld J, Dehde S, Kerjaschki D, Becker JU, et al. A new mouse model of immune-mediated podocyte injury. Kidney Int.  2007;  72: 841\u2013852.","DOI":"10.1038\/sj.ki.5002450"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Okuda S, Oh Y, Tsuruda H, Onoyama K, Fujimi S, Fujishima M. Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease. Kidney Int.  1986;  29: 502\u2013510.","DOI":"10.1038\/ki.1986.28"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Fogo AB. Animal models of FSGS: lessons for pathogenesis and treatment. Semin Nephrol.  2003;  23: 161\u2013171.","DOI":"10.1053\/snep.2003.50015"},{"key":"11","unstructured":"11. Bucciarelli E, Binazzi R, Santori P, Vespasiani G. [Nephrotic syndrome in rats due to adriamycin chlorhydrate]. Lav Ist Anat Istol Patol Univ Studi Perugia.  1976;  36: 53\u201369."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Chen A, Sheu LF, Ho YS, Lin YF, Chou WY, Chou TC, et al. Experimental focal segmental glomerulosclerosis in mice. Nephron J.  1998;  78: 440\u2013452.","DOI":"10.1159\/000044974"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Watanabe M, Takahashi Y, Hiura K, Nakano K, Okamura T, Sasaki H, et al. A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse. Biochem Biophys Res Commun.  2021;  556: 121\u2013126.","DOI":"10.1016\/j.bbrc.2021.03.150"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Watanabe M, Hiura K, Sasaki H, Okamura T, Sasaki N. Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice. Exp Anim.  2023;  72: 47\u201354.","DOI":"10.1538\/expanim.22-0057"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Papeta N, Zheng Z, Schon EA, Brosel S, Altintas MM, Nasr SH, et al. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest.  2010;  120: 4055\u20134064.","DOI":"10.1172\/JCI43721"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Dip R, Naegeli H. More than just strand breaks: the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit. FASEB J.  2005;  19: 704\u2013715.","DOI":"10.1096\/fj.04-3041rev"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Watanabe M, Ishii Y, Hashimoto K, Takimoto HR, Sasaki N. Development and characterization of a Novel FVB-Prkdc(R2140C) mouse model for adriamycin-induced nephropathy. Genes (Basel).  2024;  15: 456.","DOI":"10.3390\/genes15040456"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Watanabe M, Kakutani M, Hiura K, Sasaki H, Sasaki N. Differences in susceptibility to ADR nephropathy among C57BL\/6 substrains. Exp Anim.  2023;  72: 520\u2013525.","DOI":"10.1538\/expanim.23-0003"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Bertani T, Rocchi G, Sacchi G, Mecca G, Remuzzi G. Adriamycin-induced glomerulosclerosis in the rat. Am J Kidney Dis.  1986;  7: 12\u201319.","DOI":"10.1016\/S0272-6386(86)80051-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A, et al. Dendrin location in podocytes is associated with disease progression in animal and human glomerulopathy. Am J Nephrol.  2011;  33: 537\u2013549.","DOI":"10.1159\/000327995"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: is the podocyte the culprit? Kidney Int.  1998;  54: 687\u2013697.","DOI":"10.1046\/j.1523-1755.1998.00044.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wang Y, Wang YP, Tay YC, Harris DCH. Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events. Kidney Int.  2000;  58: 1797\u20131804.","DOI":"10.1046\/j.1523-1755.2000.00342.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Otaki Y, Miyauchi N, Higa M, Takada A, Kuroda T, Gejyo F, et al. Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis. Am J Physiol Renal Physiol.  2008;  295: F1376\u2013F1387.","DOI":"10.1152\/ajprenal.00075.2008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ding ZH, Xu LM, Wang SZ, Kou JQ, Xu YL, Chen CX, et al. Ameliorating Adriamycin-induced chronic kidney disease in rats by orally administrated cardiotoxin from Naja naja atra venom. Evid Based Complement Alternat Med.  2014;  2014: 621756.","DOI":"10.1155\/2014\/621756"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Morgan WA, Kaler B, Bach PH. The role of reactive oxygen species in adriamycin and menadione-induced glomerular toxicity. Toxicol Lett.  1998;  94: 209\u2013215.","DOI":"10.1016\/S0378-4274(98)00024-1"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Rowley DA, Halliwell B. DNA damage by superoxide-generating systems in relation to the mechanism of action of the anti-tumour antibiotic adriamycin. Biochim Biophys Acta.  1983;  761: 86\u201393.","DOI":"10.1016\/0304-4165(83)90365-3"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Gupta SC, Hevia D, Patchva S, Park B, Koh W, Aggarwal BB. Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal.  2012;  16: 1295\u20131322.","DOI":"10.1089\/ars.2011.4414"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Li X, Tao H, Xie K, Ni Z, Yan Y, Wei K, et al. cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion. PLoS One.  2014;  9: e92003.","DOI":"10.1371\/journal.pone.0092003"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Bondarev AD, Jonsson J, Chubarev VN, Tarasov VV, Lagunas-Rangel FA, Schi\u00f6th HB. Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales. Pharmacol Res.  2024;  209: 107431.","DOI":"10.1016\/j.phrs.2024.107431"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Feng J, Xie L, Lu W, Yu X, Dong H, Ma Y, et al. Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1\/CDK1\/cyclin B1 axis. Ren Fail.  2024;  46: 2365408.","DOI":"10.1080\/0886022X.2024.2365408"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Ranjan A, Iwakuma T. Non-canonical cell death induced by p53. Int J Mol Sci.  2016;  17: 2068.","DOI":"10.3390\/ijms17122068"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, et al. Megalin\/cubulin-lysosome-mediated albumin reabsorption is involved in the tubular cell activation of NLRP3 inflammasome and tubulointerstitial inflammation. J Biol Chem.  2015;  290: 18018\u201318028.","DOI":"10.1074\/jbc.M115.662064"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Wolf G, Schroeder R, Ziyadeh FN, Stahl RAK. Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells. Kidney Int.  2004;  66: 1849\u20131858.","DOI":"10.1111\/j.1523-1755.2004.00958.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Gekle M, Knaus P, Nielsen R, Mildenberger S, Freudinger R, Wohlfarth V, et al. Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells. J Physiol.  2003;  552: 471\u2013481.","DOI":"10.1111\/j.1469-7793.2003.00471.x"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Bobulescu IA. Renal lipid metabolism and lipotoxicity. Curr Opin Nephrol Hypertens.  2010;  19: 393\u2013402.","DOI":"10.1097\/MNH.0b013e32833aa4ac"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Frenk S, Antonowicz I, Craig JM, Metcoff J. Experimental nephrotic syndrome induced in rats by aminonucleoside; renal lesions and body electrolyte composition. Proc Soc Exp Biol Med.  1955;  89: 424\u2013427.","DOI":"10.3181\/00379727-89-21833"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Yin X, Wu H, Chen Y, Kang YJ. Induction of antioxidants by adriamycin in mouse heart. Biochem Pharmacol.  1998;  56: 87\u201393.","DOI":"10.1016\/S0006-2952(98)00099-9"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Hong YM, Lee H, Cho MS, Kim KC. Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model. Korean J Pediatr.  2017;  60: 365\u2013372.","DOI":"10.3345\/kjp.2017.60.11.365"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Watanabe M, Kakutani M, Ando R, Hiura K, Sasaki H, Okamura T, et al. Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism. J Vet Med Sci.  2023;  85: 702\u2013704.","DOI":"10.1292\/jvms.23-0115"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Tang SCW, Leung JCK, Chan LYY, Eddy AA, Lai KN. Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy. Kidney Int.  2008;  73: 288\u2013299.","DOI":"10.1038\/sj.ki.5002674"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Yin L, Mao Y, Song H, Wang Y, Zhou W, Zhang Z. Vincristine alleviates adriamycin-induced nephropathy through stabilizing actin cytoskeleton. Cell Biosci.  2017;  7: 1.","DOI":"10.1186\/s13578-016-0129-z"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Chang WT, Wu CC, Liao IC, Lin YW, Chen YC, Ho CH, et al. Dapagliflozin protects against doxorubicin-induced nephrotoxicity associated with nitric oxide pathway-A translational study. Free Radic Biol Med.  2023;  208: 103\u2013111.","DOI":"10.1016\/j.freeradbiomed.2023.08.013"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Li J, Tang Y, Lu G, Liu Q, Guo Y, Wang J, et al. Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4\u03b1-mediated FGF21 sensitivity. J Adv Res.  2024. in press.","DOI":"10.1016\/j.jare.2024.07.014"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Oda K, Katayama K, Zang L, Toda M, Tanoue A, Saiki R, et al. The protective role of KANK1 in podocyte injury. Int J Mol Sci.  2024;  25: 5808.","DOI":"10.3390\/ijms25115808"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Hou Y, Chen S, Peng L, Huang L, Zhang H, Zhang P, et al. Tmem30a protects against podocyte injury through suppression of pyroptosis. iScience.  2024;  27: 109976.","DOI":"10.1016\/j.isci.2024.109976"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Matoba K, Nagai Y, Sekiguchi K, Ohashi S, Mitsuyoshi E, Shimoda M, et al. Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis. Commun Biol.  2024;  7: 402\u2013403.","DOI":"10.1038\/s42003-024-06127-3"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Cunanan J, Rajyam SS, Sharif B, Udwan K, Rana A, De Gregorio V, et al. Mice with a <i>Pax2<\/i> missense variant display impaired glomerular repair. Am J Physiol Renal Physiol.  2024;  326: F704\u2013F726.","DOI":"10.1152\/ajprenal.00259.2023"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Lopes-Gon\u00e7alves G, Costa-Pessoa JM, Pimenta R, Tostes AF, da Silva EM, Ledesma FL, et al. Evaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosis. Sci Rep.  2023;  13: 22685.","DOI":"10.1038\/s41598-023-49861-0"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Lin L, Ye Y, Fu H, Gu W, Zhao M, Sun J, et al. Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism. Cell Commun Signal.  2023;  21: 324.","DOI":"10.1186\/s12964-023-01218-w"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Xu X, Qu S, Zhang C, Zhang M, Qin W, Ren G, et al. CD8 T cell-derived exosomal miR-186\u20135p elicits renal inflammation via activating tubular TLR7\/8 signal axis. Adv Sci (Weinh).  2023;  10: e2301492.","DOI":"10.1002\/advs.202301492"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Ji B, Liu J, Ma Y, Yin Y, Xu H, Shen Q, et al. Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-\u03b21-Smad2 and p53 pathways. Int Immunopharmacol.  2023;  115: 109656.","DOI":"10.1016\/j.intimp.2022.109656"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Asao R, Seki T, Takagi M, Yamada H, Kodama F, Hosoe-Nagai Y, et al. Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis. Sci Rep.  2018;  8: 5061\u20135066.","DOI":"10.1038\/s41598-018-23278-6"},{"key":"53","doi-asserted-by":"crossref","first-page":"123482","DOI":"10.1172\/jci.insight.123482","volume":"3","year":"2018","unstructured":"53. Zhong F, Chen Z, Zhang L, Xie Y, Nair V, Ju W, et al. Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight.  2018;  3: 123482.","journal-title":"JCI Insight","ISSN":"https:\/\/id.crossref.org\/issn\/2379-3708","issn-type":"print"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Mason WJ, Jafree DJ, Pomeranz G, Kolatsi-Joannou M, Rottner AK, Pacheco S, et al. Systemic gene therapy with thymosin \u03b24 alleviates glomerular injury in mice. Sci Rep.  2022;  12: 12172.","DOI":"10.1038\/s41598-022-16287-z"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Liao MC, Miyata KN, Chang SY, Zhao XP, Lo CS, El-Mortada MA, et al. Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice. Clin Sci (Lond).  2022;  136: 715\u2013731.","DOI":"10.1042\/CS20220188"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Hou Q, Le W, Kan S, Shi J, Lang Y, Liu Z, et al. Nuclear receptor interacting protein-2 mediates the stabilization and activation of \u03b2-catenin during podocyte injury. Front Cell Dev Biol.  2021;  9: 781792.","DOI":"10.3389\/fcell.2021.781792"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Bao D, Su H, Lei CT, Tang H, Ye C, Xiong W, et al. MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS. Int J Biol Sci.  2021;  17: 4396\u20134408.","DOI":"10.7150\/ijbs.62238"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Guo Y, Pace J, Li Z, Ma\u2019ayan A, Wang Z, Revelo MP, et al. Podocyte-specific induction of Kr\u00fcppel-Like Factor 15 restores differentiation markers and attenuates kidney injury in proteinuric kidney disease. J Am Soc Nephrol.  2018;  29: 2529\u20132545.","DOI":"10.1681\/ASN.2018030324"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, et al. Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis. Lab Invest.  2017;  97: 1306\u20131320.","DOI":"10.1038\/labinvest.2017.69"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Mo H, Wu Q, Miao J, Luo C, Hong X, Wang Y, et al. C-X-C chemokine receptor type 4 plays a crucial role in mediating oxidative stress-induced podocyte injury. Antioxid Redox Signal.  2017;  27: 345\u2013362.","DOI":"10.1089\/ars.2016.6758"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Zhong F, Wang W, Lee K, He JC, Chen N. Role of C\/EBP-\u03b1 in Adriamycin-induced podocyte injury. Sci Rep.  2016;  6: 33520.","DOI":"10.1038\/srep33520"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Mallipattu SK, Horne SJ, D\u2019Agati V, Narla G, Liu R, Frohman MA, et al. Kr\u00fcppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest.  2015;  125: 1347\u20131361.","DOI":"10.1172\/JCI77084"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. M\u00fchlig AK, Steingr\u00f6ver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, et al. The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice. Kidney Int.  2022;  101: 1186\u20131199.","DOI":"10.1016\/j.kint.2022.01.036"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Uchida N, Kushida Y, Kitada M, Wakao S, Kumagai N, Kuroda Y, et al. Beneficial effects of systemically administered human muse cells in adriamycin nephropathy. J Am Soc Nephrol.  2017;  28: 2946\u20132960.","DOI":"10.1681\/ASN.2016070775"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/74\/2\/74_24-0133\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T03:20:53Z","timestamp":1745637653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/74\/2\/74_24-0133\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.24-0133","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"24-0133"}}