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Cowan              LD. The            epidemiology of the epilepsies in children. Ment Retard Dev            Disabil Res Rev. 2002; 8:            171\u2013181.","DOI":"10.1002\/mrdd.10035"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kearney              JA. Advances in            epilepsy genetics and genomics. Epilepsy Curr.            2012; 12: 143\u2013146.","DOI":"10.5698\/1535-7511-12.4.143"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Wang              J, Lin              ZJ, Liu              L, Xu              HQ, Shi              YW, Yi              YH, et            al. Epilepsy-associated genes.            Seizure. 2017; 44:            11\u201320.","DOI":"10.1016\/j.seizure.2016.11.030"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dwivedi              R, Kaushik              M, Tripathi              M, Dada              R, Tiwari              P. 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Epilepsy            Res. 2009; 87:            70\u201376.","DOI":"10.1016\/j.eplepsyres.2009.07.012"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Takeda              A, Iida              M, Ando              M, Nakamura              M, Tamano              H, Oku              N. Enhanced            susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic              Zn<sup>2+<\/sup>.PLoS One. 2013;            8: e71372.","DOI":"10.1371\/journal.pone.0071372"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kiura              Y, Hanaya              R, Serikawa              T, Kurisu              K, Sakai              N, Sasa              M. Involvement            of Ca(2+) channels in abnormal excitability of hippocampal CA3 pyramidal cells in noda            epileptic rats. J Pharmacol Sci. 2003;            91: 137\u2013144.","DOI":"10.1254\/jphs.91.137"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Maihara              T, Noda              A, Yamazoe              H, Voigt              B, Kitada              K, Serikawa              T. Chromosomal            mapping of genes for epilepsy in NER: a rat strain with tonic-clonic            seizures. Epilepsia. 2000;            41: 941\u2013949.","DOI":"10.1111\/j.1528-1157.2000.tb00276.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kuramoto              T, Voigt              B, Nakanishi              S, Kitada              K, Nakamura              T, Wakamatsu              K, et            al. Identification of candidate genes for            generalized tonic-clonic seizures in noda epileptic rat. Behav            Genet. 2017; 47:            609\u2013619.","DOI":"10.1007\/s10519-017-9870-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gaillard              S, Lo Re              L, Mantilleri              A, Hepp              R, Urien              L, Malapert              P, et            al. GINIP, a G\u03b1i-interacting protein, functions as a            key modulator of peripheral GABAB receptor-mediated analgesia.            Neuron. 2014; 84:            123\u2013136.","DOI":"10.1016\/j.neuron.2014.08.056"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Serikawa              T, Kunisawa              N, Shimizu              S, Kato              M, Alves Iha              H, Kinboshi              M, et            al. Increased seizure sensitivity, emotional defects            and cognitive impairment in PHD finger protein 24 (Phf24)-null rats.            Behav Brain Res. 2019; 369:            111922.","DOI":"10.1016\/j.bbr.2019.111922"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Numakura              Y, Uemura              R, Tanaka              M, Izawa              T, Yamate              J, Kuramoto              T, et            al. PHF24 is expressed in the inhibitory            interneurons in rats. Exp Anim. 2021;            70: 137\u2013143.","DOI":"10.1538\/expanim.20-0105"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. H\u00e4rtig              W, Meinicke              A, Michalski              D, Schob              S, J\u00e4ger              C. Update on            perineuronal net staining with wisteria floribunda agglutinin (WFA).            Front Integr Nuerosci. 2022; 16:            851988.","DOI":"10.3389\/fnint.2022.851988"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. McRae              PA, Porter              BE. The            perineuronal net component of the extracellular matrix in plasticity and            epilepsy. Neurochem Int. 2012;            61: 963\u2013972.","DOI":"10.1016\/j.neuint.2012.08.007"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Gottschall              PE, Howell              MD. ADAMTS            expression and function in central nervous system injury and disorders.            Matrix Biol. 2015; 44\u201346:            70\u201376.","DOI":"10.1016\/j.matbio.2015.01.014"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Mohamedi              Y, Fontanil              T, Cobo              T, Cal              S, Obaya              AJ. New            Insights into ADAMTS metalloproteases in the central nervous system.            Biomolecules. 2020; 10:            403.","DOI":"10.3390\/biom10030403"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Stock              M, Menges              S, Eitzinger              N, Ge\u00dflein              M, Botschner              R, Wormser              L, et            al. A dual role of upper zone of growth plate and            cartilage matrix\u2013associated protein in human and mouse osteoarthritic            cartilage. Arthritis Rheumatol. 2017;            69: 1233\u20131245.","DOI":"10.1002\/art.40042"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Larkman              A, Mason              A. Correlations            between morphology and electrophysiology of pyramidal neurons in slices of rat visual            cortex. I. Establishment of cell classes. J Neurosci.            1990; 10: 1407\u20131414.","DOI":"10.1523\/JNEUROSCI.10-05-01407.1990"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Staiger              JF, Flagmeyer              I, Schubert              D, Zilles              K, K\u00f6tter              R, Luhmann              HJ. Functional            diversity of layer IV spiny neurons in rat somatosensory cortex: quantitative morphology            of electrophysiologically characterized and biocytin labeled cells.            Cereb Cortex. 2004; 14:            690\u2013701.","DOI":"10.1093\/cercor\/bhh029"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Pitk\u00e4nen              A, Sutula              TP. Is epilepsy            a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe            epilepsy. Lancet Neurol. 2002;            1: 173\u2013181.","DOI":"10.1016\/S1474-4422(02)00073-X"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Thom              M, Eriksson              S, Martinian              L, Caboclo              LO, McEvoy              AW, Duncan              JS, et            al. Temporal lobe sclerosis associated with            hippocampal sclerosis in temporal lobe epilepsy: neuropathological            features. J Neuropathol Exp Neurol. 2009;            68: 928\u2013938.","DOI":"10.1097\/NEN.0b013e3181b05d67"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Thom              M. Review:            Hippocampal sclerosis in epilepsy: a neuropathology review.            Neuropathol Appl Neurobiol. 2014; 40:            520\u2013543.","DOI":"10.1111\/nan.12150"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Harada              Y, Nagao              Y, Shimizu              S, Serikawa              T, Terada              R, Fujimoto              M, et            al. Expressional analysis of inwardly rectifying            Kir4.1 channels in Noda epileptic rat (NER). Brain Res.            2013; 1517: 141\u2013149.","DOI":"10.1016\/j.brainres.2013.04.009"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Choi              WS, Lee              E, Lim              J, Oh              YJ.            Calbindin-D28K prevents drug-induced dopaminergic neuronal death by            inhibiting caspase and calpain activity. Biochem Biophys Res            Commun. 2008; 371:            127\u2013131.","DOI":"10.1016\/j.bbrc.2008.04.020"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kook              SY, Jeong              H, Kang              MJ, Park              R, Shin              HJ, Han              SH, et            al. Crucial role of calbindin-D<sub>28k<\/sub> in the            pathogenesis of Alzheimer\u2019s disease mouse model. Cell Death            Differ. 2014; 21:            1575\u20131587.","DOI":"10.1038\/cdd.2014.67"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Allison              DW, Chervin              AS, Gelfand              VI, Craig              AM.            Postsynaptic scaffolds of excitatory and inhibitory synapses in            hippocampal neurons: maintenance of core components independent of actin filaments and            microtubules. J Neurosci. 2000;            20: 4545\u20134554.","DOI":"10.1523\/JNEUROSCI.20-12-04545.2000"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Tewari              BP, Chaunsali              L, Campbell              SL, Patel              DC, Goode              AE,                Sontheimer              H. Perineuronal            nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model            of epilepsy. Nat Commun. 2018;            9: 4724.","DOI":"10.1038\/s41467-018-07113-0"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Chaunsali              L, Tewari              BP,                Sontheimer              H. Perineuronal            net dynamics in the pathophysiology of epilepsy. Epilepsy            Curr. 2021; 21:            273\u2013281.","DOI":"10.1177\/15357597211018688"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Ueno              H, Suemitsu              S, Murakami              S, Kitamura              N, Wani              K, Takahashi              Y, et            al. Alteration of extracellular matrix molecules and            perineuronal nets in the hippocampus of pentylenetetrazol-kindled mice.            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